Insider Stock Trading History of Isaly Samuel D


The following table details the trading activities (stock purchases, stock sales, and stock option exercises) reported to the Securities and Exchange Commission (SEC) by insider Isaly Samuel D since year 2005. The trader's CIK number is 1055949. At the time of this reporting, Isaly Samuel D is the 10% Owner of Rhythm Pharmaceuticals, Inc. . (stock ticker symbol RYTM). See this page for all insider trading activities at Rhythm Pharmaceuticals, Inc. .

Note that in the past ISALY SAMUEL D also reported insider trading activities as an insider of the following companies:

Insider Activities at Rhythm Pharmaceuticals, Inc. (RYTM)
Insider Activities at Roka Bioscience, Inc. (ROKA)
Insider Activities at Audentes Therapeutics, Inc. (BOLD)
Insider Activities at Glaukos Corp (GKOS)
Insider Activities at Kala Pharmaceuticals, Inc. (KALA)
Insider Activities at Steadymed Ltd. (STDY)
Insider Activities at Adaptimmune Therapeutics Plc (ADAP)
Insider Activities at Aerpio Pharmaceuticals, Inc. (NONE)
Insider Activities at Aeglea Biotherapeutics, Inc. (AGLE)
Insider Activities at Viewray, Inc. (VRAY)
Insider Activities at Loxo Oncology, Inc. (LOXO)
Insider Activities at Relypsa Inc (RLYP)
Insider Activities at Selecta Biosciences Inc (SELB)
Insider Activities at Corvus Pharmaceuticals, Inc. (CRVS)
Insider Activities at Intellia Therapeutics, Inc. (NTLA)
Insider Activities at Otonomy, Inc. (OTIC)
Insider Activities at Dimension Therapeutics, Inc. (DMTX)
Insider Activities at Sientra, Inc. (SIEN)
Insider Activities at Pieris Pharmaceuticals, Inc. (PIRS)
Insider Activities at Intercept Pharmaceuticals Inc (ICPT)
Insider Activities at Mirati Therapeutics, Inc. (MRTX)
Insider Activities at Ambit Biosciences Corp (AMBI)
Insider Activities at Anthera Pharmaceuticals Inc (ANTH)
Insider Activities at Amarin Corp Plc\uk (AMRN)
Insider Activities at Complete Genomics Inc (GNOM)
Insider Activities at Supernus Pharmaceuticals Inc (SUPN)
Insider Activities at Pacira Pharmaceuticals, Inc. (PCRX)
Insider Activities at Bthc Vi Inc (BVIC)
Insider Activities at Nxstage Medical, Inc. (NXTM)
Insider Activities at Biodel Inc (BIOD)
Insider Activities at Aryx Therapeutics, Inc. (ARYX)
Insider Activities at Cryocor Inc (CRYO)

Stock purchases, sales, and option exercises reported by insider Isaly Samuel D since 2005.
  Trade Date   Symbol Company Name (Issuer) Trade Type     Shares       Price ($)   Value ($)
2017-10-10 RYTM Rhythm Pharmaceuticals, Inc. Buy 355,000 17.00 6,035,000
2017-10-03 ROKA Roka Bioscience, Inc. Sale 201,617 .68 137,099
2017-09-28 ROKA Roka Bioscience, Inc. Sale 380,542 .72 273,990
2017-09-29 ROKA Roka Bioscience, Inc. Sale 94,134 .74 69,659
2017-09-29 BOLD Audentes Therapeutics, Inc. Sale 672,000 28.25 18,984,000
2017-09-26 ROKA Roka Bioscience, Inc. Sale 74,802 1.03 77,046
2017-09-27 ROKA Roka Bioscience, Inc. Sale 52,799 .92 48,575
2017-09-07 BOLD Audentes Therapeutics, Inc. Sale 5,000 22.35 111,750
2017-09-01 GKOS Glaukos Corp Sale 110,078 37.72 4,152,142
2017-08-31 GKOS Glaukos Corp Sale 44,922 37.82 1,698,950
2017-09-05 GKOS Glaukos Corp Sale 425,200 39.45 16,772,864
2017-08-23 ROKA Roka Bioscience, Inc. Sale 1,100 1.50 1,650
2017-08-24 ROKA Roka Bioscience, Inc. Sale 13,200 1.50 19,800
2017-08-18 ROKA Roka Bioscience, Inc. Sale 66,796 1.52 101,529
2017-08-21 ROKA Roka Bioscience, Inc. Sale 2,980 1.49 4,440
2017-08-22 ROKA Roka Bioscience, Inc. Sale 5,500 1.52 8,360
2017-08-17 GKOS Glaukos Corp Sale 226,920 37.85 8,588,922
2017-08-16 GKOS Glaukos Corp Sale 65,580 38.01 2,492,695
2017-08-15 GKOS Glaukos Corp Sale 32,500 38.29 1,244,425
2017-07-25 KALA Kala Pharmaceuticals, Inc. Buy 319,333 15.00 4,789,995
2017-04-25 STDY Steadymed Ltd. Buy 1,174,000 5.90 6,926,600
2017-03-27 ADAP Adaptimmune Therapeutics Plc Buy 1,190,476 4.20 4,999,999
2017-03-15 NONE Aerpio Pharmaceuticals, Inc. Buy 762,995 5.00 3,814,975
2017-03-14 GKOS Glaukos Corp Sale 74,100 44.54 3,300,414
2017-03-13 GKOS Glaukos Corp Sale 211,410 45.72 9,664,608
2017-03-10 GKOS Glaukos Corp Sale 97,028 45.98 4,461,347
2017-03-03 GKOS Glaukos Corp Sale 55,772 47.05 2,624,072
2017-02-21 AGLE Aeglea Biotherapeutics, Inc. Buy 7,000 5.36 37,520
2017-02-17 AGLE Aeglea Biotherapeutics, Inc. Buy 71,800 5.19 372,642
2017-02-16 AGLE Aeglea Biotherapeutics, Inc. Buy 30,500 5.04 153,720
2017-01-18 VRAY Viewray, Inc. Buy 330,577 3.00 991,731
2016-08-22 VRAY Viewray, Inc. Buy 1,138,074 2.95 3,357,318
2016-08-11 GKOS Glaukos Corp Sale 160,900 33.63 5,411,067
2016-08-12 GKOS Glaukos Corp Sale 14,100 33.72 475,452
2016-08-10 GKOS Glaukos Corp Sale 117,938 33.77 3,982,766
2016-08-10 LOXO Loxo Oncology, Inc. Sale 447,857 26.96 12,074,224
2016-08-03 GKOS Glaukos Corp Sale 425,000 30.59 13,000,750
2016-07-22 RLYP Relypsa Inc Sale 3,700,000 32.00 118,400,000
2016-07-25 RLYP Relypsa Inc Sale 343,600 31.98 10,988,328
2016-06-27 SELB Selecta Biosciences Inc Buy 550,000 14.00 7,700,000
2016-06-27 SELB Selecta Biosciences Inc Buy 550,000 14.00 7,700,000
2016-06-23 CRVS Corvus Pharmaceuticals, Inc. Buy 100 12.92 1,292
2016-06-24 CRVS Corvus Pharmaceuticals, Inc. Buy 900 12.99 11,691
2016-06-21 CRVS Corvus Pharmaceuticals, Inc. Buy 26,083 12.87 335,688
2016-06-17 CRVS Corvus Pharmaceuticals, Inc. Buy 12,300 12.48 153,504
2016-06-14 CRVS Corvus Pharmaceuticals, Inc. Buy 10,000 12.71 127,100
2016-06-15 CRVS Corvus Pharmaceuticals, Inc. Buy 5,000 11.94 59,700
2016-06-16 CRVS Corvus Pharmaceuticals, Inc. Buy 5,000 12.04 60,199
2016-06-09 CRVS Corvus Pharmaceuticals, Inc. Buy 30,000 12.95 388,500
2016-06-10 CRVS Corvus Pharmaceuticals, Inc. Buy 20,000 12.98 259,600
2016-05-20 ADAP Adaptimmune Therapeutics Plc Buy 2,400 10.04 24,095
2016-05-24 ADAP Adaptimmune Therapeutics Plc Buy 518,400 10.48 5,432,832
2016-05-23 ADAP Adaptimmune Therapeutics Plc Buy 1,191,600 10.40 12,392,640
2016-05-20 CRVS Corvus Pharmaceuticals, Inc. Buy 4,716 13.09 61,732
2016-05-18 CRVS Corvus Pharmaceuticals, Inc. Buy 4,200 11.55 48,510
2016-05-19 CRVS Corvus Pharmaceuticals, Inc. Buy 2,600 12.43 32,318
2016-05-11 NTLA Intellia Therapeutics, Inc. Buy 250,000 18.00 4,500,000
2015-12-23 RLYP Relypsa Inc Sale 100,000 27.16 2,716,000
2015-12-22 RLYP Relypsa Inc Sale 150,000 26.70 4,005,749
2015-12-21 RLYP Relypsa Inc Sale 250,000 27.95 6,986,250
2015-11-25 OTIC Otonomy, Inc. Sale 34,800 28.91 1,006,068
2015-11-27 OTIC Otonomy, Inc. Sale 29,000 28.97 840,130
2015-11-30 OTIC Otonomy, Inc. Sale 3,306 28.93 95,642
2015-11-23 OTIC Otonomy, Inc. Sale 80,800 28.45 2,298,760
2015-11-20 OTIC Otonomy, Inc. Sale 83,900 28.59 2,398,701
2015-11-24 OTIC Otonomy, Inc. Sale 36,100 28.75 1,037,875
2015-11-17 OTIC Otonomy, Inc. Sale 11,098 28.95 321,231
2015-11-19 OTIC Otonomy, Inc. Sale 127,300 28.60 3,640,780
2015-10-27 DMTX Dimension Therapeutics, Inc. Buy 200,000 13.00 2,600,000
2015-10-22 RLYP Relypsa Inc Buy 500,000 12.45 6,222,500
2015-10-12 SIEN Sientra, Inc. Sale 287,891 5.98 1,721,588
2015-10-09 SIEN Sientra, Inc. Sale 212,709 7.03 1,495,344
2015-10-08 SIEN Sientra, Inc. Sale 400,000 7.24 2,896,000
2015-10-07 SIEN Sientra, Inc. Sale 53,900 7.36 396,704
2015-10-05 SIEN Sientra, Inc. Sale 138,100 8.19 1,131,039
2015-10-06 SIEN Sientra, Inc. Sale 7,000 7.80 54,600
2015-10-02 SIEN Sientra, Inc. Sale 47,900 10.34 495,286
2015-09-29 SIEN Sientra, Inc. Sale 10,558 10.08 106,424
2015-09-30 SIEN Sientra, Inc. Sale 43,840 10.17 445,852
2015-10-01 SIEN Sientra, Inc. Sale 47,500 10.34 491,150
2015-09-25 SIEN Sientra, Inc. Sale 132,000 10.57 1,395,240
2015-09-24 SIEN Sientra, Inc. Sale 8,306 10.59 87,985
2015-09-28 SIEN Sientra, Inc. Sale 10,602 10.30 109,200
2015-07-06 PIRS Pieris Pharmaceuticals, Inc. Buy 500,000 2.75 1,375,000
2015-06-30 GKOS Glaukos Corp Option Ex 27,607 .00 0
2015-05-18 RLYP Relypsa Inc Sale 1,457,551 34.13 49,746,215
2015-03-26 ICPT Intercept Pharmaceuticals Inc Sale 157,200 287.71 45,228,797
2015-03-23 ICPT Intercept Pharmaceuticals Inc Sale 159,400 278.64 44,415,056
2015-03-24 ICPT Intercept Pharmaceuticals Inc Sale 45,600 271.80 12,394,034
2015-03-25 ICPT Intercept Pharmaceuticals Inc Sale 2,800 270.23 756,644
2015-02-03 MRTX Mirati Therapeutics, Inc. Buy 100,000 20.00 2,000,000
2014-09-16 RLYP Relypsa Inc Sale 45,000 25.75 1,158,975
2014-09-17 RLYP Relypsa Inc Sale 49,000 25.07 1,228,430
2014-08-26 ICPT Intercept Pharmaceuticals Inc Sale 61,258 300.74 18,422,424
2014-08-25 ICPT Intercept Pharmaceuticals Inc Sale 50,000 296.01 14,800,500
2014-08-15 RLYP Relypsa Inc Sale 990,000 26.35 26,086,500
2014-08-18 OTIC Otonomy, Inc. Buy 171,875 16.00 2,750,000
2014-08-14 ICPT Intercept Pharmaceuticals Inc Sale 60,000 300.36 18,021,780
2014-08-09 ICPT Intercept Pharmaceuticals Inc Option Ex 324 .00 0
2014-08-06 LOXO Loxo Oncology, Inc. Buy 275,385 13.00 3,580,005
2014-07-22 ROKA Roka Bioscience, Inc. Buy 383,333 12.00 4,599,996
2014-06-30 MRTX Mirati Therapeutics, Inc. Sale 14,000 20.72 290,080
2014-07-01 MRTX Mirati Therapeutics, Inc. Sale 5,000 20.04 100,200
2014-06-27 MRTX Mirati Therapeutics, Inc. Sale 88,332 22.44 1,982,170
2014-05-07 ICPT Intercept Pharmaceuticals Inc Option Ex 1,330 .00 0
2014-05-09 ICPT Intercept Pharmaceuticals Inc Option Ex 325 .00 0
2014-04-09 ICPT Intercept Pharmaceuticals Inc Sale 81,305 320.00 26,017,600
2014-02-09 ICPT Intercept Pharmaceuticals Inc Option Ex 324 .00 0
2013-11-20 RLYP Relypsa Inc Option Ex 1,744,711 .17 296,600
2013-11-20 RLYP Relypsa Inc Buy 712,192 11.00 7,834,112
2013-11-09 ICPT Intercept Pharmaceuticals Inc Option Ex 325 .00 0
2013-10-29 MRTX Mirati Therapeutics, Inc. Buy 125,000 17.50 2,187,500
2013-10-21 ICPT Intercept Pharmaceuticals Inc Sale 40,088 62.50 2,505,500
2013-10-15 ICPT Intercept Pharmaceuticals Inc Sale 376,585 62.50 23,536,562
2013-08-09 ICPT Intercept Pharmaceuticals Inc Option Ex 325 .00 0
2013-05-22 AMBI Ambit Biosciences Corp Buy 21,300 6.86 146,139
2013-05-23 AMBI Ambit Biosciences Corp Buy 12,500 6.99 87,362
2013-05-20 AMBI Ambit Biosciences Corp Buy 10,600 6.78 71,836
2013-05-21 AMBI Ambit Biosciences Corp Buy 669,871 7.63 5,112,455
2013-05-09 ICPT Intercept Pharmaceuticals Inc Option Ex 324 .00 0
2013-04-09 ICPT Intercept Pharmaceuticals Inc Option Ex 649 .00 0
2013-01-30 ANTH Anthera Pharmaceuticals Inc Buy 5,700,000 .66 3,762,000
2013-01-25 ANTH Anthera Pharmaceuticals Inc Buy 1,762,000 .65 1,141,776
2012-10-16 ICPT Intercept Pharmaceuticals Inc Buy 333,334 15.00 5,000,010
2012-09-04 AMRN Amarin Corp Plc\\uk Sale 233,700 14.43 3,372,992
2012-07-27 AMRN Amarin Corp Plc\\uk Sale 366,300 14.61 5,350,544
2012-07-13 GNOM Complete Genomics Inc Sale 479,300 2.51 1,203,522
2012-07-11 GNOM Complete Genomics Inc Sale 507,936 2.90 1,472,506
2012-07-12 GNOM Complete Genomics Inc Sale 220,700 2.85 628,995
2012-06-29 ANTH Anthera Pharmaceuticals Inc Sale 1,283,300 .73 941,942
2012-06-19 AMRN Amarin Corp Plc\\uk Sale 617,100 12.91 7,968,612
2012-05-04 SUPN Supernus Pharmaceuticals Inc Buy 1,100,000 5.00 5,500,000
2012-03-20 ANTH Anthera Pharmaceuticals Inc Sale 116,800 2.90 338,603
2012-03-21 ANTH Anthera Pharmaceuticals Inc Sale 125,000 2.87 358,250
2012-03-22 ANTH Anthera Pharmaceuticals Inc Sale 1,306,700 2.40 3,140,000
2012-03-09 PCRX Pacira Pharmaceuticals, Inc. Sale 37,000 11.25 416,102
2012-03-12 PCRX Pacira Pharmaceuticals, Inc. Sale 63,100 11.03 696,119
2012-02-28 PCRX Pacira Pharmaceuticals, Inc. Sale 10,100 11.12 112,311
2012-02-27 PCRX Pacira Pharmaceuticals, Inc. Sale 29,000 11.05 320,363
2012-02-29 PCRX Pacira Pharmaceuticals, Inc. Sale 3,000 10.86 32,583
2012-02-01 PCRX Pacira Pharmaceuticals, Inc. Sale 70,000 11.01 770,420
2012-02-02 PCRX Pacira Pharmaceuticals, Inc. Sale 23,300 10.86 252,921
2012-02-03 PCRX Pacira Pharmaceuticals, Inc. Sale 50,000 10.79 539,500
2011-12-09 ANTH Anthera Pharmaceuticals Inc Sale 40,000 6.75 270,000
2011-12-13 ANTH Anthera Pharmaceuticals Inc Sale 16,200 6.50 105,300
2011-11-18 ANTH Anthera Pharmaceuticals Inc Sale 3,000 6.50 19,500
2011-11-17 ANTH Anthera Pharmaceuticals Inc Sale 24,000 6.67 160,080
2011-11-16 ANTH Anthera Pharmaceuticals Inc Sale 25,000 6.87 171,750
2011-11-14 ANTH Anthera Pharmaceuticals Inc Sale 5,000 6.95 34,750
2011-11-15 ANTH Anthera Pharmaceuticals Inc Sale 50,000 6.93 346,500
2011-11-11 ANTH Anthera Pharmaceuticals Inc Sale 5,000 7.14 35,700
2011-10-31 PCRX Pacira Pharmaceuticals, Inc. Sale 97,441 10.53 1,025,663
2011-06-10 ANTH Anthera Pharmaceuticals Inc Sale 30,000 8.18 245,400
2011-06-09 ANTH Anthera Pharmaceuticals Inc Sale 37,000 8.11 300,070
2011-06-08 ANTH Anthera Pharmaceuticals Inc Sale 33,000 8.02 264,660
2011-05-09 ANTH Anthera Pharmaceuticals Inc Sale 10,000 7.26 72,600
2011-05-10 ANTH Anthera Pharmaceuticals Inc Sale 106,400 7.23 769,272
2011-05-11 ANTH Anthera Pharmaceuticals Inc Sale 13,000 7.22 93,860
2011-05-17 ANTH Anthera Pharmaceuticals Inc Sale 100,000 8.32 832,000
2011-05-18 ANTH Anthera Pharmaceuticals Inc Sale 69,334 8.03 556,752
2011-05-16 ANTH Anthera Pharmaceuticals Inc Sale 12,000 7.20 86,400
2011-05-26 ANTH Anthera Pharmaceuticals Inc Sale 34,200 8.53 291,726
2011-05-25 ANTH Anthera Pharmaceuticals Inc Sale 4,800 8.65 41,520
2011-05-17 ANTH Anthera Pharmaceuticals Inc Sale 100,000 8.32 832,000
2011-05-18 ANTH Anthera Pharmaceuticals Inc Sale 69,334 8.03 556,752
2011-05-16 ANTH Anthera Pharmaceuticals Inc Sale 12,000 7.20 86,400
2011-05-09 ANTH Anthera Pharmaceuticals Inc Sale 10,000 7.26 72,600
2011-05-10 ANTH Anthera Pharmaceuticals Inc Sale 106,400 7.23 769,272
2011-05-11 ANTH Anthera Pharmaceuticals Inc Sale 13,000 7.22 93,860
2011-05-02 AMRN Amarin Corp Plc\\uk Sale 32,900 16.30 536,270
2011-04-29 AMRN Amarin Corp Plc\\uk Sale 100,000 16.01 1,601,000
2011-04-14 ATHX Bthc Vi Inc Sale 20,900 2.91 60,819
2011-04-11 ATHX Bthc Vi Inc Sale 13,000 2.91 37,830
2011-04-26 ATHX Bthc Vi Inc Sale 7,700 2.90 22,330
2011-04-25 ATHX Bthc Vi Inc Sale 36,600 2.90 106,140
2011-04-21 ATHX Bthc Vi Inc Sale 2,000 2.90 5,800
2011-04-18 ATHX Bthc Vi Inc Sale 15,700 2.93 46,001
2011-04-20 ATHX Bthc Vi Inc Sale 1,300 2.90 3,770
2011-04-15 ATHX Bthc Vi Inc Sale 30,200 2.90 87,580
2011-04-12 ATHX Bthc Vi Inc Sale 14,300 2.90 41,470
2011-04-13 ATHX Bthc Vi Inc Sale 47,700 2.94 140,238
2011-04-21 AMRN Amarin Corp Plc\\uk Sale 750,000 16.55 12,408,750
2011-04-20 AMRN Amarin Corp Plc\\uk Sale 800,000 15.79 12,632,000
2011-04-18 AMRN Amarin Corp Plc\\uk Sale 3,000,000 15.59 46,770,000
2011-03-24 AMRN Amarin Corp Plc\\uk Sale 23,000 7.50 172,500
2011-03-25 AMRN Amarin Corp Plc\\uk Sale 56,900 7.47 425,043
2011-03-28 AMRN Amarin Corp Plc\\uk Sale 93,100 7.35 684,285
2011-03-21 AMRN Amarin Corp Plc\\uk Sale 77,000 7.05 542,850
2011-03-11 AMRN Amarin Corp Plc\\uk Sale 100,000 7.43 743,000
2011-03-15 AMRN Amarin Corp Plc\\uk Sale 50,000 7.24 362,000
2011-03-14 AMRN Amarin Corp Plc\\uk Sale 75,000 7.33 549,750
2011-03-03 AMRN Amarin Corp Plc\\uk Sale 7,000 7.76 54,320
2011-03-04 AMRN Amarin Corp Plc\\uk Sale 43,000 7.62 327,660
2011-03-07 AMRN Amarin Corp Plc\\uk Sale 25,000 7.68 192,000
2011-03-02 AMRN Amarin Corp Plc\\uk Sale 95,000 7.72 733,400
2011-03-01 AMRN Amarin Corp Plc\\uk Sale 50,000 7.56 378,000
2011-02-28 AMRN Amarin Corp Plc\\uk Sale 100,000 7.73 773,000
2011-02-08 PCRX Pacira Pharmaceuticals, Inc. Buy 535,714 7.00 3,749,998
2010-12-09 NXTM Nxstage Medical, Inc. Sale 2,356 22.60 53,255
2010-09-30 ANTH Anthera Pharmaceuticals Inc Buy 19,900 4.08 81,192
2010-09-15 NXTM Nxstage Medical, Inc. Sale 54,000 16.23 876,420
2010-09-13 NXTM Nxstage Medical, Inc. Sale 100,000 16.70 1,670,000
2010-09-10 NXTM Nxstage Medical, Inc. Sale 193,900 16.52 3,203,228
2010-09-14 NXTM Nxstage Medical, Inc. Sale 96,000 16.49 1,583,039
2010-09-07 NXTM Nxstage Medical, Inc. Sale 40,100 16.79 673,279
2010-09-08 NXTM Nxstage Medical, Inc. Sale 7,000 16.50 115,500
2010-09-09 NXTM Nxstage Medical, Inc. Sale 8,800 16.36 143,968
2010-08-18 NXTM Nxstage Medical, Inc. Sale 100,200 16.94 1,697,388
2010-08-17 NXTM Nxstage Medical, Inc. Sale 288,000 17.06 4,913,280
2010-08-16 NXTM Nxstage Medical, Inc. Sale 112,000 17.11 1,916,320
2010-08-03 NXTM Nxstage Medical, Inc. Sale 199,200 16.41 3,269,469
2010-08-04 NXTM Nxstage Medical, Inc. Sale 101,100 16.31 1,648,738
2010-08-02 NXTM Nxstage Medical, Inc. Sale 17,400 16.39 285,099
2010-07-27 NXTM Nxstage Medical, Inc. Sale 572,556 16.93 9,691,082
2010-07-28 NXTM Nxstage Medical, Inc. Sale 128,000 16.66 2,131,968
2009-06-10 BIOD Biodel Inc Sale 26,988 5.24 141,417
2009-05-22 ARYX Aryx Therapeutics, Inc. Sale 2,000,000 4.00 8,000,000
2009-03-16 ATHX Bthc Vi Inc Buy 52,200 .65 33,930
2009-03-17 ATHX Bthc Vi Inc Buy 110,000 .84 92,400
2008-11-14 ARYX Aryx Therapeutics, Inc. Buy 1,214,646 .00 0
2008-08-26 NXTM Nxstage Medical, Inc. Buy 27,700 3.50 97,033
2008-08-21 NXTM Nxstage Medical, Inc. Buy 26,100 3.25 84,825
2008-08-25 NXTM Nxstage Medical, Inc. Buy 108,900 3.37 367,101
2008-05-23 NXTM Nxstage Medical, Inc. Buy 5,555,556 4.50 25,000,002
2008-05-22 ATHX Bthc Vi Inc Buy 268,000 2.40 643,200
2008-05-21 ATHX Bthc Vi Inc Buy 130,000 2.40 312,000
2008-05-13 ATHX Bthc Vi Inc Buy 50,000 2.40 120,000
2008-02-12 BIOD Biodel Inc Sale 154,000 14.48 2,229,920
2007-11-13 ARYX Aryx Therapeutics, Inc. Buy 300,000 10.00 3,000,000
2005-07-13 CRYO Cryocor Inc Sale 135,000 11.00 1,485,000

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Isaly Samuel D (10% Owner of Rhythm Pharmaceuticals, Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.