Stock Trading History of Wedel Mark K

The following table details the trading activities (stock purchases, stock sales, and stock option exercises) reported to the Securities and Exchange Commission (SEC) by insider Wedel Mark K since year 2005. The trader's CIK number is 1321261. At the time of this reporting, Wedel Mark K is the VP & Chief Medical Officer of Isis Pharmaceuticals Inc (stock ticker symbol ISIS).

Stock purchases, sales, and option exercises reported by *Wedel Mark K* since 2005.
Trade Date	Symbol	Company Name (Issuer)	Trade Type	Shares	Price ($)	Value ($)
2007-07-06	ISIS	Isis Pharmaceuticals Inc	Sale	5,200	10.12	52,626
2007-07-06	ISIS	Isis Pharmaceuticals Inc	Option Exercise	5,200	5.52	28,730
2007-07-02	ISIS	Isis Pharmaceuticals Inc	Sale	902	9.70	8,752
2007-05-09	ISIS	Isis Pharmaceuticals Inc	Sale	2,800	10.36	29,019
2007-05-09	ISIS	Isis Pharmaceuticals Inc	Option Exercise	2,800	5.15	14,420
2007-05-02	ISIS	Isis Pharmaceuticals Inc	Sale	2,000	10.25	20,500
2007-05-02	ISIS	Isis Pharmaceuticals Inc	Option Exercise	2,000	5.15	10,300
2007-04-25	ISIS	Isis Pharmaceuticals Inc	Sale	13,711	10.11	138,618
2007-04-25	ISIS	Isis Pharmaceuticals Inc	Option Exercise	10,000	4.60	45,950

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Wedel Mark K (VP & Chief Medical Officer of Isis Pharmaceuticals Inc at the time of this reporting) see the Securities and Exchange Commission (SEC) website.