Insider Trading activities of Medicines Co /de insiders.

Monthly summaries of insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Medicines Co /de since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Medicines Co /de since year 2005. Table 2 shows the detailed insider transactions of Medicines Co /de since 2005. The reporting company's ticker symbol is MDCO. The reporting company's CIK number is 1113481.
The total value of stock buying since 2005 is $58,620,971.
The total value of stock sales since 2005 is $95,816,439.
The total value of stock option exercises since 2005 is $46,994,241.


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Table 1. Monthly summaries of insider stock purchases, sales, and option exercises for Medicines Co /de (MDCO).
Trading Period Insider Buying Insider Sales Option Exercises
year-month Shares Value Shares Value Shares Value
2017-12 200,000 $5,311,000 0 $0 0 $0
2017-11 173,215 $5,204,668 0 $0 47,798 $701,770
2017-05 0 $0 0 $0 22,500 $441,000
2017-03 0 $0 0 $0 15,000 $294,000
2017-02 0 $0 83,335 $4,070,810 83,335 $2,111,921
2016-12 727,220 $24,470,472 0 $0 40,000 $1,144,000
2016-11 0 $0 20,000 $800,060 20,000 $572,000
2016-09 0 $0 10,000 $400,000 10,000 $285,999
2016-08 0 $0 20,000 $800,000 20,000 $572,000
2016-07 0 $0 3,849 $148,186 0 $0
2016-06 99,325 $3,743,141 60,000 $2,205,600 60,000 $1,572,000
2016-05 300,000 $10,104,000 50,000 $1,801,795 50,000 $1,030,000
2016-03 0 $0 16,717 $579,371 15,000 $279,000
2016-02 0 $0 0 $0 15,000 $279,000
2015-11 0 $0 5,000 $196,700 5,000 $93,000
2015-09 0 $0 25,000 $1,050,000 25,000 $551,000
2015-08 0 $0 236,611 $9,263,505 236,611 $4,660,383
2015-07 0 $0 16,667 $473,242 16,667 $304,506
2015-06 0 $0 27,472 $791,627 16,667 $304,506
2015-05 0 $0 74,142 $1,971,278 91,667 $1,913,256
2015-04 0 $0 17,948 $498,022 16,667 $304,506
2015-03 0 $0 81,928 $2,445,604 36,667 $758,006
2014-03 0 $0 2,968 $89,960 0 $0
2014-02 0 $0 10,000 $342,920 0 $0
2014-01 0 $0 224,694 $8,699,863 214,311 $4,627,658
2013-12 0 $0 50,616 $1,893,096 21,016 $575,004
2013-11 0 $0 170,190 $6,286,252 158,523 $4,192,946
2013-10 0 $0 39,428 $1,388,558 31,354 $504,662
2013-09 0 $0 81,894 $2,804,270 73,500 $2,080,785
2013-08 0 $0 7,500 $234,450 0 $0
2013-07 0 $0 43,500 $1,422,375 36,000 $855,720
2013-06 0 $0 109,973 $3,660,671 109,973 $2,008,106
2013-05 0 $0 83,613 $2,899,835 89,654 $1,681,178
2013-04 0 $0 7,500 $250,274 1,667 $28,655
2013-03 0 $0 57,009 $1,872,887 45,759 $909,210
2013-02 0 $0 73,004 $2,308,262 24,046 $494,929
2013-01 0 $0 236,527 $6,995,875 221,746 $4,110,646
2012-12 0 $0 31,500 $688,040 20,000 $343,800
2012-11 0 $0 13,593 $285,724 13,593 $210,691
2012-10 0 $0 13,600 $314,024 13,600 $210,800
2012-09 0 $0 14,159 $372,372 13,600 $210,800
2012-08 0 $0 70,751 $1,779,344 53,100 $888,700
2012-07 0 $0 98,607 $2,314,718 93,607 $1,547,408
2012-06 0 $0 5,000 $108,600 0 $0
2012-05 9,150 $200,385 5,000 $110,800 0 $0
2012-04 0 $0 32,500 $691,600 38,750 $329,087
2012-03 0 $0 6,665 $142,115 8,125 $68,393
2012-02 0 $0 35,265 $741,967 5,625 $50,218
2012-01 0 $0 5,625 $109,586 625 $4,568
2011-12 0 $0 22,956 $444,548 625 $4,568
2011-11 0 $0 6,760 $127,263 625 $4,568
2011-10 0 $0 3,125 $54,362 625 $4,568
2011-09 0 $0 1,250 $18,887 1,250 $9,136
2011-07 0 $0 3,125 $52,281 625 $4,568
2011-06 0 $0 3,125 $58,125 625 $4,568
2011-05 0 $0 15,354 $268,840 8,125 $108,068
2011-04 0 $0 547,990 $8,948,816 0 $0
2011-03 0 $0 207,717 $3,427,379 0 $0
2011-02 0 $0 109,190 $1,877,137 21,875 $201,906
2010-09 88,049 $1,152,561 0 $0 0 $0
2010-08 667,040 $8,037,832 10,127 $121,220 0 $0
2010-05 0 $0 6,250 $46,625 0 $0
2010-04 0 $0 175,250 $1,316,127 237,000 $1,135,230
2009-05 2,000 $14,154 0 $0 0 $0
2009-03 0 $0 3,125 $31,181 0 $0
2008-12 5,000 $61,395 0 $0 0 $0
2008-11 2,000 $24,484 0 $0 0 $0
2008-03 0 $0 3,125 $59,456 0 $0
2007-08 12,000 $184,310 0 $0 0 $0
2007-07 0 $0 1,000 $20,000 0 $0
2007-06 0 $0 1,000 $20,000 0 $0
2007-05 1,000 $21,740 1,000 $22,704 0 $0
2007-04 0 $0 2,000 $50,928 0 $0
2007-03 0 $0 5,125 $132,560 0 $0
2007-02 0 $0 2,000 $61,280 0 $0
2007-01 0 $0 52,000 $1,658,750 68,333 $1,228,644
2006-12 0 $0 2,000 $57,302 0 $0
2006-11 0 $0 2,000 $51,152 0 $0
2006-10 0 $0 12,000 $292,750 10,000 $91,300
2006-09 0 $0 1,000 $22,565 0 $0
2006-08 0 $0 6,000 $130,683 5,000 $45,650
2006-07 0 $0 1,000 $20,000 0 $0
2006-02 0 $0 5,964 $119,280 5,000 $45,650
2005-10 2,900 $48,841 0 $0 0 $0
2005-07 2,000 $41,988 0 $0 0 $0

Table 2. Detailed insider stock purchases, sales, and option exercises of Medicines Co /de insiders (MDCO)
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2017-12-08 Eshelman Fredric N (Executive Chairman) Buy 100,000 26.65 2,665,000
2017-12-07 Eshelman Fredric N (Executive Chairman) Buy 100,000 26.46 2,646,000
2017-11-30 Panayiotopoulos Paris Buy 3,215 30.97 99,568
2017-11-29 Denner Alexander J (Director) Buy 170,000 30.03 5,105,100
2017-11-09 Hugin Robert J Option Ex 47,798 14.68 701,770
2017-05-23 Spigelman Melvin K Option Ex 7,500 19.60 147,000
2017-05-16 Wyatt Elizabeth H S Option Ex 7,500 19.60 147,000
2017-05-12 Crouse William Option Ex 7,500 19.60 147,000
2017-03-13 Kessler Armin M Option Ex 7,500 19.60 147,000
2017-03-08 Hugin Robert J Option Ex 7,500 19.60 147,000
2017-02-10 O'connor William Bernard (Chief Financial Officer) Sale 57,502 50.00 2,875,100
2017-02-10 O'connor William Bernard (Chief Financial Officer) Option Ex 57,502 25.11 1,444,162
2017-02-07 O'connor William Bernard (Chief Financial Officer) Sale 15,000 47.22 708,225
2017-02-07 O'connor William Bernard (Chief Financial Officer) Option Ex 15,000 28.60 429,000
2017-02-03 O'connor William Bernard (Chief Financial Officer) Sale 10,833 45.00 487,485
2017-02-03 O'connor William Bernard (Chief Financial Officer) Option Ex 10,833 22.04 238,759
2016-12-08 Cox Christopher T (EVP & Chief Corp. Dev. Officer) Buy 16,500 32.52 536,580
2016-12-08 Eshelman Fredric N Buy 24,689 32.85 811,033
2016-12-07 Cox Christopher T (EVP & Chief Corp. Dev. Officer) Buy 89,000 33.33 2,966,370
2016-12-07 Meanwell Clive (CEO) Option Ex 40,000 28.60 1,144,000
2016-12-07 Eshelman Fredric N Buy 259,351 33.26 8,624,717
2016-12-06 Eshelman Fredric N Buy 337,680 34.15 11,531,772
2016-11-15 Meanwell Clive (CEO) Sale 20,000 40.00 800,060
2016-11-15 Meanwell Clive (CEO) Option Ex 20,000 28.60 572,000
2016-09-21 Meanwell Clive (CEO) Sale 8,623 40.00 344,920
2016-09-21 Meanwell Clive (CEO) Option Ex 8,623 28.60 246,617
2016-09-01 Meanwell Clive (CEO) Sale 1,377 40.00 55,080
2016-09-01 Meanwell Clive (CEO) Option Ex 1,377 28.60 39,382
2016-08-24 Meanwell Clive (CEO) Sale 20,000 40.00 800,000
2016-08-24 Meanwell Clive (CEO) Option Ex 20,000 28.60 572,000
2016-07-11 Shigeta Hiroaki Sale 3,849 38.50 148,186
2016-06-13 Shigeta Hiroaki Sale 40,000 36.76 1,470,400
2016-06-13 Shigeta Hiroaki Option Ex 40,000 26.20 1,048,000
2016-06-10 Cox Christopher T (EVP & Chief Corp. Dev. Officer) Buy 20,010 37.22 744,672
2016-06-08 Cox Christopher T (EVP & Chief Corp. Dev. Officer) Buy 25,975 38.43 998,219
2016-06-07 Cox Christopher T (EVP & Chief Corp. Dev. Officer) Buy 53,340 37.50 2,000,250
2016-05-24 Spigelman Melvin K Sale 15,000 37.00 555,000
2016-05-24 Spigelman Melvin K Option Ex 15,000 18.60 279,000
2016-05-24 Savage Robert G. Sale 10,000 36.95 369,500
2016-05-24 Savage Robert G. Option Ex 10,000 18.60 186,000
2016-05-16 Meanwell Clive (CEO) Sale 10,000 35.00 350,000
2016-05-16 Meanwell Clive (CEO) Option Ex 10,000 28.60 286,000
2016-05-16 Crouse William Sale 15,000 35.15 527,295
2016-05-16 Crouse William Option Ex 15,000 18.60 279,000
2016-05-12 Eshelman Fredric N Buy 300,000 33.68 10,104,000
2016-03-07 Kessler Armin M Sale 8,100 34.82 282,042
2016-03-07 Kessler Armin M Option Ex 15,000 18.60 279,000
2016-03-04 O'connor William Bernard (Chief Financial Officer) Sale 8,617 34.51 297,329
2016-02-17 Hugin Robert J Option Ex 15,000 18.60 279,000
2015-11-13 Savage Robert G. Sale 5,000 39.34 196,700
2015-11-13 Savage Robert G. Option Ex 5,000 18.60 93,000
2015-09-03 Sblendorio Glenn (President & CFO) Sale 25,000 42.00 1,050,000
2015-09-03 Sblendorio Glenn (President & CFO) Option Ex 25,000 22.04 551,000
2015-08-31 O'connor William Bernard (SVP & Chief Acct. Officer) Sale 35,451 40.00 1,418,040
2015-08-31 O'connor William Bernard (SVP & Chief Acct. Officer) Option Ex 35,451 14.91 528,680
2015-08-31 Spigelman Melvin K Sale 20,000 40.50 810,000
2015-08-31 Spigelman Melvin K Option Ex 20,000 20.87 417,400
2015-08-31 Sblendorio Glenn (President & CFO) Sale 114,495 39.75 4,551,634
2015-08-31 Sblendorio Glenn (President & CFO) Option Ex 114,495 21.80 2,496,334
2015-08-31 Meanwell Clive (CEO) Sale 49,998 39.36 1,967,871
2015-08-31 Meanwell Clive (CEO) Option Ex 49,998 18.27 913,463
2015-08-03 Meanwell Clive (Chairman & CEO) Sale 16,667 30.96 515,960
2015-08-03 Meanwell Clive (Chairman & CEO) Option Ex 16,667 18.27 304,506
2015-07-01 Meanwell Clive (Chairman & CEO) Sale 16,667 28.39 473,242
2015-07-01 Meanwell Clive (Chairman & CEO) Option Ex 16,667 18.27 304,506
2015-06-25 Sblendorio Glenn (President & CFO) Sale 3,305 32.00 105,760
2015-06-08 Shigeta Hiroaki Sale 7,500 28.99 217,425
2015-06-01 Meanwell Clive (Chairman & CEO) Sale 16,667 28.11 468,442
2015-06-01 Meanwell Clive (Chairman & CEO) Option Ex 16,667 18.27 304,506
2015-05-22 Hugin Robert J Option Ex 15,000 21.45 321,750
2015-05-20 Savage Robert G. Sale 15,000 26.78 401,640
2015-05-20 Savage Robert G. Option Ex 15,000 21.45 321,750
2015-05-19 Wyatt Elizabeth H S Sale 15,000 26.80 401,985
2015-05-19 Wyatt Elizabeth H S Option Ex 15,000 21.45 321,750
2015-05-19 Crouse William Sale 15,000 26.86 402,900
2015-05-19 Crouse William Option Ex 15,000 21.45 321,750
2015-05-13 Kessler Armin M Sale 12,475 25.87 322,728
2015-05-13 Kessler Armin M Option Ex 15,000 21.45 321,750
2015-05-01 Meanwell Clive (Chairman & CEO) Sale 16,667 26.52 442,025
2015-05-01 Meanwell Clive (Chairman & CEO) Option Ex 16,667 18.27 304,506
2015-04-16 O'connor William Bernard (SVP & Chief Acct. Officer) Sale 1,281 30.00 38,430
2015-04-01 Meanwell Clive (Chairman & CEO) Sale 16,667 27.57 459,592
2015-04-01 Meanwell Clive (Chairman & CEO) Option Ex 16,667 18.27 304,506
2015-03-30 Wyatt Elizabeth H S Sale 20,000 28.08 561,540
2015-03-30 Wyatt Elizabeth H S Option Ex 20,000 22.68 453,500
2015-03-23 Sblendorio Glenn (President & CFO) Sale 34,773 30.78 1,070,312
2015-03-23 Meanwell Clive (Chairman & CEO) Sale 16,667 30.62 510,393
2015-03-23 Meanwell Clive (Chairman & CEO) Option Ex 16,667 18.27 304,506
2015-03-16 Savage Robert G. Sale 7,500 28.98 217,365
2015-03-02 O'connor William Bernard (SVP & Chief Acct. Officer) Sale 2,988 28.78 85,994
2014-03-03 O'connor William Bernard (Sr VP & Chief Acct. Officer) Sale 2,968 30.31 89,960
2014-02-03 Meanwell Clive (Chairman & CEO) Sale 10,000 34.29 342,920
2014-01-21 Antinori Paul Michael (Sr. VP & General Counsel) Sale 37,883 37.99 1,439,213
2014-01-21 Antinori Paul Michael (Sr. VP & General Counsel) Option Ex 37,500 13.19 494,737
2014-01-15 O'connor William Bernard (Sr VP & Chief Acct. Officer) Sale 1,250 40.00 50,000
2014-01-15 O'connor William Bernard (Sr VP & Chief Acct. Officer) Option Ex 1,250 22.04 27,550
2014-01-14 O'connor William Bernard (Sr VP & Chief Acct. Officer) Sale 3,177 38.81 123,299
2014-01-14 O'connor William Bernard (Sr VP & Chief Acct. Officer) Option Ex 3,177 12.38 39,331
2014-01-10 O'connor William Bernard (Sr VP & Chief Acct. Officer) Sale 72,384 40.00 2,895,360
2014-01-10 O'connor William Bernard (Sr VP & Chief Acct. Officer) Option Ex 72,384 17.46 1,264,041
2014-01-07 Meanwell Clive (Chairman & CEO) Sale 24,627 38.13 938,953
2014-01-07 Meanwell Clive (Chairman & CEO) Option Ex 24,627 28.02 690,048
2014-01-06 Meanwell Clive (Chairman & CEO) Sale 3,302 38.13 125,905
2014-01-06 Meanwell Clive (Chairman & CEO) Option Ex 3,302 28.02 92,522
2014-01-03 Meanwell Clive (Chairman & CEO) Sale 47,516 38.20 1,814,873
2014-01-03 Meanwell Clive (Chairman & CEO) Option Ex 47,516 28.02 1,331,398
2014-01-02 Meanwell Clive (Chairman & CEO) Sale 34,555 37.98 1,312,260
2014-01-02 Meanwell Clive (Chairman & CEO) Option Ex 24,555 28.02 688,031
2013-12-13 Antinori Paul Michael (Sr. VP & General Counsel) Sale 9,600 36.91 354,335
2013-12-12 Antinori Paul Michael (Sr. VP & General Counsel) Sale 10,000 37.01 370,110
2013-12-09 Crouse William Sale 12,500 38.00 475,025
2013-12-09 Crouse William Option Ex 12,500 32.30 403,749
2013-12-05 Sblendorio Glenn (President & CFO) Sale 326 38.50 12,551
2013-12-05 Sblendorio Glenn (President & CFO) Option Ex 326 20.11 6,555
2013-12-04 Sblendorio Glenn (President & CFO) Sale 8,190 38.50 315,315
2013-12-04 Sblendorio Glenn (President & CFO) Option Ex 8,190 20.11 164,700
2013-12-02 Meanwell Clive (Chairman & CEO) Sale 10,000 36.58 365,760
2013-11-26 Meanwell Clive (Chairman & CEO) Sale 25,136 36.66 921,485
2013-11-26 Meanwell Clive (Chairman & CEO) Option Ex 25,136 28.01 704,059
2013-11-25 Shigeta Hiroaki Sale 17,039 37.19 633,680
2013-11-25 Shigeta Hiroaki Option Ex 17,039 21.14 360,204
2013-11-25 Meanwell Clive (Chairman & CEO) Sale 109,864 36.71 4,033,107
2013-11-25 Meanwell Clive (Chairman & CEO) Option Ex 99,864 28.01 2,797,190
2013-11-18 Sblendorio Glenn (President & CFO) Sale 16,484 38.50 634,634
2013-11-18 Sblendorio Glenn (President & CFO) Option Ex 16,484 20.11 331,493
2013-11-14 Sblendorio Glenn (President & CFO) Sale 1,667 38.00 63,346
2013-10-25 Sblendorio Glenn (President & CFO) Sale 25,574 35.79 915,293
2013-10-25 Sblendorio Glenn (President & CFO) Option Ex 25,000 17.04 426,000
2013-10-23 O'connor William Bernard (Sr VP & Chief Acct. Officer) Sale 6,354 35.00 222,390
2013-10-23 O'connor William Bernard (Sr VP & Chief Acct. Officer) Option Ex 6,354 12.38 78,662
2013-10-01 Meanwell Clive (Chairman & CEO) Sale 7,500 33.45 250,875
2013-09-27 Antinori Paul Michael (Sr. VP & General Counsel) Sale 894 33.16 29,645
2013-09-13 Antinori Paul Michael (Sr. VP & General Counsel) Sale 73,500 34.50 2,535,750
2013-09-13 Antinori Paul Michael (Sr. VP & General Counsel) Option Ex 73,500 28.31 2,080,785
2013-09-03 Meanwell Clive (Chairman & CEO) Sale 7,500 31.85 238,875
2013-08-01 Meanwell Clive (Chairman & CEO) Sale 7,500 31.26 234,450
2013-07-08 Antinori Paul Michael (Sr. VP & General Counsel) Sale 36,000 33.00 1,188,000
2013-07-08 Antinori Paul Michael (Sr. VP & General Counsel) Option Ex 36,000 23.77 855,720
2013-07-01 Meanwell Clive (Chairman & CEO) Sale 7,500 31.25 234,375
2013-06-11 Antinori Paul Michael (Sr. VP & General Counsel) Sale 109,973 33.29 3,660,671
2013-06-11 Antinori Paul Michael (Sr. VP & General Counsel) Option Ex 109,973 18.26 2,008,106
2013-05-29 Kessler Armin M Sale 8,750 33.05 289,187
2013-05-29 Kessler Armin M Option Ex 12,500 23.00 287,500
2013-05-22 Hugin Robert J Option Ex 12,500 23.00 287,500
2013-05-10 Sblendorio Glenn (President & CFO) Sale 2,709 37.00 100,233
2013-05-09 O'connor William Bernard (Sr VP & Chief Acct. Officer) Sale 29,654 35.00 1,037,890
2013-05-09 O'connor William Bernard (Sr VP & Chief Acct. Officer) Option Ex 29,654 16.46 488,253
2013-05-09 Antinori Paul Michael (Sr. VP & General Counsel) Sale 35,000 34.90 1,221,500
2013-05-09 Antinori Paul Michael (Sr. VP & General Counsel) Option Ex 35,000 17.66 617,925
2013-05-01 Meanwell Clive (Chairman & CEO) Sale 7,500 33.47 251,025
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Insider trading activities including stock purchases, stock sales, and option exercises of MDCO listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Medicines Co /de (symbol MDCO, CIK number 1113481) see the Securities and Exchange Commission (SEC) website.