Insider Trading activities of Isis Pharmaceuticals Inc insiders. , Part 2

Monthly summaries of insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Isis Pharmaceuticals Inc since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Isis Pharmaceuticals Inc since year 2005. (See page 1 of this report.) Table 2 shows the detailed insider transactions of Isis Pharmaceuticals Inc since 2005. The reporting company's ticker symbol is IONS. The reporting company's CIK number is 874015.
The total value of stock buying since 2005 is $90,940.
The total value of stock sales since 2005 is $143,411,749.
The total value of stock option exercises since 2005 is $46,743,600.



Table 2. Detailed insider stock purchases, sales, and option exercises of Isis Pharmaceuticals Inc insiders (IONS) , Part 2
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2016-01-15 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 5,543 .00 0
2016-01-15 Geary Richard S (SVP, Development) Option Ex 5,427 .00 0
2016-01-15 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 4,762 .00 0
2016-01-15 Bennett C Frank (SVP, Antisense Research) Option Ex 5,295 .00 0
2016-01-15 Parshall B Lynne (COO & Secretary) Option Ex 13,267 .00 0
2016-01-15 Crooke Stanley T (Chairman and CEO) Option Ex 24,661 .00 0
2016-01-05 Crooke Stanley T (Chairman and CEO) Sale 5,500 62.10 341,550
2016-01-05 Crooke Stanley T (Chairman and CEO) Option Ex 5,500 9.76 53,652
2016-01-04 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 61.10 61,100
2016-01-04 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 9.04 9,035
2016-01-04 Monia Brett P (SVP, Antisense Drug Discovery) Sale 127 61.00 7,747
2016-01-04 Parshall B Lynne (COO & Secretary) Sale 809 61.05 49,389
2016-01-04 Parshall B Lynne (COO & Secretary) Option Ex 809 14.69 11,884
2016-01-04 Crooke Stanley T (Chairman and CEO) Sale 11,000 61.05 671,550
2016-01-04 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 9.76 107,305
2015-12-16 Bennett C Frank (SVP, Antisense Research) Sale 3,909 58.85 230,044
2015-12-16 Bennett C Frank (SVP, Antisense Research) Option Ex 3,909 14.47 56,563
2015-12-15 Bennett C Frank (SVP, Antisense Research) Sale 4,000 56.00 224,000
2015-12-15 Bennett C Frank (SVP, Antisense Research) Option Ex 4,000 14.47 57,880
2015-12-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 61.50 61,500
2015-12-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 7.25 7,250
2015-11-11 Klein Joseph Iii (Director) Sale 6,875 64.18 441,237
2015-11-11 Klein Joseph Iii (Director) Option Ex 6,875 11.12 76,450
2015-11-10 Bennett C Frank (SVP, Antisense Research) Sale 5,000 64.00 320,000
2015-11-10 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 14.47 72,350
2015-11-06 Bennett C Frank (SVP, Antisense Research) Sale 5,000 56.00 280,000
2015-11-06 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 14.47 72,350
2015-11-03 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 51.95 51,950
2015-11-03 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 7.25 7,250
2015-10-23 Crooke Stanley T (Chairman and CEO) Sale 27,500 44.57 1,225,675
2015-10-23 Crooke Stanley T (Chairman and CEO) Option Ex 27,500 10.06 276,595
2015-10-21 Crooke Stanley T (Chairman and CEO) Sale 16,500 43.00 709,500
2015-10-21 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 10.59 174,685
2015-10-02 Parshall B Lynne (COO & Secretary) Sale 5,436 41.25 224,218
2015-10-02 Parshall B Lynne (COO & Secretary) Option Ex 5,436 14.69 79,854
2015-10-01 Parshall B Lynne (COO & Secretary) Sale 7,000 40.13 280,882
2015-10-01 Parshall B Lynne (COO & Secretary) Option Ex 7,000 10.97 76,790
2015-07-06 Parshall B Lynne (COO & Secretary) Sale 6,218 57.01 354,469
2015-07-06 Parshall B Lynne (COO & Secretary) Option Ex 6,218 8.77 54,531
2015-07-06 Crooke Stanley T (Chairman and CEO) Sale 6,175 57.01 352,018
2015-07-06 Crooke Stanley T (Chairman and CEO) Option Ex 6,175 10.24 63,262
2015-07-02 Monia Brett P (SVP, Antisense Drug Discovery) Sale 198 56.30 11,147
2015-07-02 Klein Joseph Iii (Director) Option Ex 312 .00 0
2015-07-02 Muto Frederick T (Director) Option Ex 312 .00 0
2015-07-02 Berthelsen Spencer R (Director) Option Ex 312 .00 0
2015-07-02 Wender Joseph H (Director) Option Ex 312 .00 0
2015-07-01 Castleman Breaux (Director) Option Ex 2,074 .00 0
2015-07-01 Loscalzo Joseph (Director) Option Ex 667 .00 0
2015-07-01 Klein Joseph Iii (Director) Option Ex 1,136 .00 0
2015-07-01 Muto Frederick T (Director) Option Ex 1,136 .00 0
2015-07-01 Berthelsen Spencer R (Director) Option Ex 1,136 .00 0
2015-07-01 Parshall B Lynne (COO & Secretary) Sale 6,218 57.56 357,914
2015-07-01 Parshall B Lynne (COO & Secretary) Option Ex 6,218 10.29 63,983
2015-07-01 Wender Joseph H (Director) Option Ex 1,136 .00 0
2015-07-01 Crooke Stanley T (Chairman and CEO) Sale 6,175 57.56 355,439
2015-07-01 Crooke Stanley T (Chairman and CEO) Option Ex 6,175 10.24 63,262
2015-06-08 Monia Brett P (SVP, Antisense Drug Discovery) Sale 7,600 66.22 503,279
2015-06-08 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 7,600 10.29 78,204
2015-06-01 Muto Frederick T (Director) Sale 10,000 66.91 669,110
2015-06-01 Muto Frederick T (Director) Option Ex 10,000 3.95 39,500
2015-04-17 Berthelsen Spencer R (Director) Option Ex 10,000 3.95 39,500
2015-04-07 Parshall B Lynne (COO & Secretary) Sale 5,565 63.07 350,990
2015-04-07 Parshall B Lynne (COO & Secretary) Option Ex 5,565 14.69 81,749
2015-04-07 Crooke Stanley T (Chairman and CEO) Sale 22,377 63.07 1,411,339
2015-04-07 Crooke Stanley T (Chairman and CEO) Option Ex 22,377 10.24 229,252
2015-04-01 Parshall B Lynne (COO & Secretary) Sale 5,377 61.93 333,008
2015-04-01 Parshall B Lynne (COO & Secretary) Option Ex 5,377 14.69 78,988
2015-04-01 Crooke Stanley T (Chairman and CEO) Sale 21,623 61.93 1,339,155
2015-04-01 Crooke Stanley T (Chairman and CEO) Option Ex 21,623 10.24 221,527
2015-03-24 Bennett C Frank (SVP, Antisense Research) Sale 9,000 71.01 639,090
2015-03-24 Bennett C Frank (SVP, Antisense Research) Option Ex 9,000 14.47 130,230
2015-03-23 Bennett C Frank (SVP, Antisense Research) Sale 6,000 70.40 422,412
2015-03-23 Bennett C Frank (SVP, Antisense Research) Option Ex 6,000 14.47 86,820
2015-03-19 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 30,525 74.81 2,283,483
2015-03-19 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 30,525 19.82 605,005
2015-03-19 Geary Richard S (SVP, Development) Sale 8,000 75.00 600,032
2015-03-19 Geary Richard S (SVP, Development) Option Ex 8,000 14.69 117,520
2015-03-19 Hougen Elizabeth L (SVP, Finance & CFO) Sale 10,000 73.33 733,259
2015-03-19 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 10,000 11.27 112,700
2015-03-18 Wender Joseph H (Director) Sale 12,500 71.40 892,450
2015-03-18 Wender Joseph H (Director) Option Ex 12,500 5.93 74,125
2015-03-05 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 5,800 71.67 415,674
2015-03-05 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 5,800 9.14 53,041
2015-03-05 Geary Richard S (SVP, Development) Sale 18,095 71.33 1,290,734
2015-03-05 Geary Richard S (SVP, Development) Option Ex 15,080 9.60 144,813
2015-03-05 Klein Joseph Iii (Director) Sale 7,000 70.95 496,685
2015-03-05 Klein Joseph Iii (Director) Option Ex 10,000 10.49 104,870
2015-03-05 Hougen Elizabeth L (SVP, Finance & CFO) Sale 28,094 71.55 2,010,153
2015-03-05 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 28,094 9.66 271,303
2015-03-05 Wender Joseph H (Director) Sale 12,500 71.61 895,175
2015-03-05 Wender Joseph H (Director) Option Ex 12,500 9.77 122,125
2015-03-02 Wender Joseph H (Director) Sale 7,000 65.97 461,782
2015-02-12 Wender Joseph H (Director) Sale 10,000 62.15 621,460
2015-02-12 Wender Joseph H (Director) Option Ex 10,000 3.95 39,500
2015-02-03 Loscalzo Joseph (Director) Option Ex 938 .00 0
2015-01-27 Crooke Stanley T (Chairman and CEO) Sale 11,000 72.93 802,186
2015-01-27 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.24 112,694
2015-01-16 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,291 67.96 87,741
2015-01-16 Monia Brett P (SVP, Antisense Drug Discovery) Sale 1,534 67.96 104,256
2015-01-16 Geary Richard S (SVP, Development) Sale 1,543 67.96 104,868
2015-01-16 Hougen Elizabeth L (SVP, Finance & CFO) Sale 1,291 67.96 87,741
2015-01-16 Bennett C Frank (SVP, Antisense Research) Sale 1,518 67.96 103,169
2015-01-16 Parshall B Lynne (COO & Secretary) Sale 4,093 67.96 278,176
2015-01-16 Crooke Stanley T (Chairman and CEO) Sale 9,054 67.96 615,346
2015-01-15 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 3,383 .00 0
2015-01-15 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 4,025 .00 0
2015-01-15 Geary Richard S (SVP, Development) Option Ex 4,049 .00 0
2015-01-15 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 3,383 .00 0
2015-01-15 Bennett C Frank (SVP, Antisense Research) Option Ex 3,984 .00 0
2015-01-15 Parshall B Lynne (COO & Secretary) Option Ex 7,748 .00 0
2015-01-15 Crooke Stanley T (Chairman and CEO) Option Ex 17,425 .00 0
2015-01-12 Geary Richard S (SVP, Development) Sale 597 73.10 43,640
2015-01-09 Crooke Stanley T (Chairman and CEO) Sale 11,000 73.57 809,269
2015-01-09 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.24 112,694
2015-01-07 Crooke Stanley T (Chairman and CEO) Sale 11,000 68.05 748,528
2015-01-07 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.24 112,694
2015-01-06 Crooke Stanley T (Chairman and CEO) Sale 11,000 66.04 726,418
2015-01-06 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.24 112,694
2015-01-02 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,500 62.12 93,172
2015-01-02 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,500 9.04 13,552
2015-01-02 Monia Brett P (SVP, Antisense Drug Discovery) Sale 76 62.75 4,769
2015-01-02 Parshall B Lynne (COO & Secretary) Sale 11,200 62.12 695,688
2015-01-02 Parshall B Lynne (COO & Secretary) Option Ex 11,200 14.69 164,528
2014-12-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,500 51.21 76,815
2014-12-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,500 7.25 10,875
2014-11-03 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,500 46.17 69,255
2014-11-03 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,500 7.25 10,875
2014-10-30 Parshall B Lynne (COO & Secretary) Sale 11,071 45.12 499,534
2014-10-30 Parshall B Lynne (COO & Secretary) Option Ex 11,071 10.97 121,448
2014-10-23 Crooke Stanley T (Chairman and CEO) Sale 14,600 42.22 616,412
2014-10-23 Crooke Stanley T (Chairman and CEO) Option Ex 14,600 11.65 170,133
2014-10-03 Crooke Stanley T (Chairman and CEO) Sale 14,000 39.49 552,818
2014-10-03 Crooke Stanley T (Chairman and CEO) Option Ex 14,000 11.85 165,830
2014-10-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,500 38.10 57,150
2014-10-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,500 8.26 12,394
2014-10-01 Crooke Stanley T (Chairman and CEO) Sale 22,000 37.91 834,042
2014-10-01 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 11.65 256,366
2014-09-02 O'neil Patrick R. (SVP, Legal and General Counsel) Sale 1,500 40.45 60,675
2014-09-02 O'neil Patrick R. (SVP, Legal and General Counsel) Option Ex 1,500 10.29 15,434
2014-09-02 Parshall B Lynne (COO) Sale 11,071 40.24 445,508
2014-09-02 Parshall B Lynne (COO) Option Ex 11,071 8.77 97,092
2014-08-27 Bennett C Frank (SVP, Antisense Research) Sale 5,000 40.53 202,635
2014-08-27 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 15.38 76,900
2014-08-26 Monia Brett P (SVP, Antisense Drug Discovery) Sale 27,344 38.14 1,043,009
2014-08-26 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 27,344 9.60 262,584
2014-08-13 Crooke Stanley T (Chairman, President and CEO) Sale 17,100 35.45 606,263
2014-08-13 Crooke Stanley T (Chairman, President and CEO) Option Ex 17,100 12.87 220,077
2014-08-12 O'neil Patrick R. (SVP, Legal and General Counsel) Sale 800 35.00 28,000
2014-08-12 O'neil Patrick R. (SVP, Legal and General Counsel) Option Ex 800 10.29 8,232
2014-08-11 O'neil Patrick R. (SVP, Legal and General Counsel) Sale 700 35.00 24,500

Insider trading activities including stock purchases, stock sales, and option exercises of IONS listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Isis Pharmaceuticals Inc (symbol IONS, CIK number 874015) see the Securities and Exchange Commission (SEC) website.