Insider Trading activities of Isis Pharmaceuticals Inc insiders. , Part 5

Monthly summaries of insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Isis Pharmaceuticals Inc since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Isis Pharmaceuticals Inc since year 2005. (See page 1 of this report.) Table 2 shows the detailed insider transactions of Isis Pharmaceuticals Inc since 2005. The reporting company's ticker symbol is IONS. The reporting company's CIK number is 874015.
The total value of stock buying since 2005 is $90,940.
The total value of stock sales since 2005 is $143,411,749.
The total value of stock option exercises since 2005 is $46,743,600.



Table 2. Detailed insider stock purchases, sales, and option exercises of Isis Pharmaceuticals Inc insiders (IONS) , Part 5
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2012-07-03 Geary Richard S (Sr VP, Development) Sale 2,434 12.91 31,422
2012-07-03 Bennett C Frank (SVP, Antisense Research) Sale 6,000 12.91 77,460
2012-07-03 Bennett C Frank (SVP, Antisense Research) Option Ex 6,000 6.84 41,040
2012-06-25 Berthelsen Spencer R (Director) Sale 10,000 11.54 115,450
2012-06-25 Berthelsen Spencer R (Director) Option Ex 10,000 8.15 81,500
2012-06-22 Reed John C (Director) Sale 10,000 11.06 110,600
2012-06-22 Reed John C (Director) Option Ex 10,000 8.15 81,500
2012-06-14 Geary Richard S (Sr VP, Development) Sale 1,579 10.86 17,147
2012-06-12 Wender Joseph H (Director) Option Ex 10,000 8.15 81,500
2012-05-22 Berthelsen Spencer R (Director) Sale 17,269 9.56 165,091
2012-05-22 Berthelsen Spencer R (Director) Option Ex 17,269 9.40 162,328
2012-05-21 Berthelsen Spencer R (Director) Sale 2,731 9.42 25,726
2012-05-21 Berthelsen Spencer R (Director) Option Ex 2,731 9.40 25,671
2011-12-21 Geary Richard S (Senior Vice President) Sale 1,144 6.92 7,916
2011-12-21 Geary Richard S (Senior Vice President) Option Ex 1,144 5.80 6,635
2011-12-21 Bennett C Frank (Senior Vice President) Sale 1,555 6.92 10,760
2011-12-21 Bennett C Frank (Senior Vice President) Option Ex 1,555 5.80 9,019
2011-12-21 Parshall B Lynne (Director, COO) Sale 6,763 6.92 46,799
2011-12-21 Parshall B Lynne (Director, COO) Option Ex 6,763 5.80 39,225
2011-12-21 Crooke Stanley T (Chairman, President, CEO) Sale 17,800 6.92 123,176
2011-12-21 Crooke Stanley T (Chairman, President, CEO) Option Ex 17,800 5.80 103,240
2011-12-20 Geary Richard S (Senior Vice President) Sale 1,800 6.87 12,366
2011-12-20 Geary Richard S (Senior Vice President) Option Ex 1,800 5.80 10,440
2011-12-20 Bennett C Frank (Senior Vice President) Sale 2,500 6.87 17,175
2011-12-20 Bennett C Frank (Senior Vice President) Option Ex 2,500 5.80 14,500
2011-12-20 Parshall B Lynne (Director, COO) Sale 10,600 6.87 72,822
2011-12-20 Parshall B Lynne (Director, COO) Option Ex 10,600 5.80 61,480
2011-12-20 Crooke Stanley T (Chairman, President, CEO) Sale 28,700 6.87 197,169
2011-12-20 Crooke Stanley T (Chairman, President, CEO) Option Ex 28,700 5.80 166,460
2011-12-19 Geary Richard S (Senior Vice President) Sale 1,100 6.86 7,546
2011-12-19 Geary Richard S (Senior Vice President) Option Ex 1,100 5.80 6,380
2011-12-19 Bennett C Frank (Senior Vice President) Sale 1,500 6.86 10,290
2011-12-19 Bennett C Frank (Senior Vice President) Option Ex 1,500 5.80 8,700
2011-12-19 Parshall B Lynne (Director, COO) Sale 6,900 6.86 47,334
2011-12-19 Parshall B Lynne (Director, COO) Option Ex 8,900 87.83 781,678
2011-12-19 Crooke Stanley T (Chairman, President, CEO) Sale 18,100 6.86 124,166
2011-12-19 Crooke Stanley T (Chairman, President, CEO) Option Ex 18,100 5.80 104,980
2011-12-16 Geary Richard S (Senior Vice President) Sale 1,000 6.79 6,790
2011-12-16 Geary Richard S (Senior Vice President) Option Ex 1,000 5.80 5,800
2011-12-16 Bennett C Frank (Senior Vice President) Sale 1,500 6.79 10,185
2011-12-16 Bennett C Frank (Senior Vice President) Option Ex 1,500 5.80 8,700
2011-12-16 Parshall B Lynne (Director, COO) Sale 6,000 6.79 40,740
2011-12-16 Parshall B Lynne (Director, COO) Option Ex 4,000 5.80 23,200
2011-12-16 Crooke Stanley T (Chairman, President, CEO) Sale 16,500 6.79 112,035
2011-12-16 Crooke Stanley T (Chairman, President, CEO) Option Ex 16,500 5.80 95,700
2011-08-04 Bennett C Frank (Senior Vice President) Sale 10,000 7.62 76,210
2011-08-04 Bennett C Frank (Senior Vice President) Option Ex 10,000 5.25 52,500
2011-07-28 Bennett C Frank (Senior Vice President) Sale 1,000 8.60 8,600
2010-12-29 Geary Richard S (Senior Vice President) Sale 1,980 10.31 20,423
2010-12-29 Geary Richard S (Senior Vice President) Option Ex 1,980 9.62 19,057
2010-12-29 Bennett C Frank (Senior Vice President) Sale 4,600 10.31 47,449
2010-12-29 Bennett C Frank (Senior Vice President) Option Ex 4,600 9.62 44,275
2010-12-29 Parshall B Lynne (Director, COO) Sale 6,400 10.31 66,016
2010-12-29 Parshall B Lynne (Director, COO) Option Ex 6,400 9.62 61,600
2010-12-29 Crooke Stanley T (Chairman, President, CEO) Sale 12,000 10.31 123,780
2010-12-29 Crooke Stanley T (Chairman, President, CEO) Option Ex 12,000 9.62 115,500
2010-12-27 Geary Richard S (Senior Vice President) Sale 3,300 10.42 34,386
2010-12-27 Geary Richard S (Senior Vice President) Option Ex 3,300 9.62 31,762
2010-12-27 Bennett C Frank (Senior Vice President) Sale 7,700 10.42 80,234
2010-12-27 Bennett C Frank (Senior Vice President) Option Ex 7,700 9.62 74,112
2010-12-27 Parshall B Lynne (Director, COO) Sale 10,800 10.42 112,536
2010-12-27 Parshall B Lynne (Director, COO) Option Ex 10,800 9.62 103,950
2010-12-27 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 10.42 208,400
2010-12-27 Crooke Stanley T (Chairman, President, CEO) Option Ex 20,000 9.62 192,500
2010-12-23 Geary Richard S (Senior Vice President) Sale 600 10.53 6,315
2010-12-23 Geary Richard S (Senior Vice President) Option Ex 600 9.62 5,775
2010-12-23 Bennett C Frank (Senior Vice President) Sale 1,500 10.53 15,787
2010-12-23 Bennett C Frank (Senior Vice President) Option Ex 1,500 9.62 14,437
2010-12-23 Parshall B Lynne (COO) Sale 2,100 10.53 22,102
2010-12-23 Parshall B Lynne (COO) Option Ex 2,100 9.62 20,212
2010-12-23 Crooke Stanley T (Chairman, President, CEO) Sale 4,000 10.53 42,100
2010-12-23 Crooke Stanley T (Chairman, President, CEO) Option Ex 4,000 9.62 38,500
2010-12-22 Geary Richard S (Senior Vice President) Sale 2,600 10.52 27,352
2010-12-22 Geary Richard S (Senior Vice President) Option Ex 2,600 9.62 25,025
2010-12-22 Bennett C Frank (Senior Vice President) Sale 6,200 10.52 65,224
2010-12-22 Bennett C Frank (Senior Vice President) Option Ex 6,200 9.62 59,675
2010-12-22 Parshall B Lynne (COO) Sale 4,350 10.52 45,762
2010-12-22 Parshall B Lynne (COO) Option Ex 13,050 9.92 129,495
2010-12-22 Crooke Stanley T (Chairman, President, CEO) Sale 16,000 10.52 168,320
2010-12-22 Crooke Stanley T (Chairman, President, CEO) Option Ex 16,000 9.62 154,000
2010-07-23 Bennett C Frank (Senior Vice President) Sale 1,100 9.60 10,560
2010-06-30 Bennett C Frank (Senior Vice President) Sale 1,000 9.75 9,750
2010-06-30 Bennett C Frank (Senior Vice President) Option Ex 1,000 5.80 5,800
2010-06-29 Bennett C Frank (Senior Vice President) Sale 3,000 9.71 29,138
2010-06-29 Bennett C Frank (Senior Vice President) Option Ex 3,000 5.80 17,400
2010-06-28 Bennett C Frank (Senior Vice President) Sale 6,000 10.01 60,060
2010-06-28 Bennett C Frank (Senior Vice President) Option Ex 6,000 5.80 34,800
2009-12-31 Parshall B Lynne (Director, COO) Sale 7,090 11.21 79,478
2009-12-31 Parshall B Lynne (Director, COO) Option Ex 7,090 6.81 48,304
2009-12-30 Parshall B Lynne (Director, COO) Sale 6,000 11.06 66,390
2009-12-30 Parshall B Lynne (Director, COO) Option Ex 6,000 6.81 40,878
2009-12-30 Wender Joseph H (Director) Option Ex 10,000 6.81 68,100
2009-12-30 Crooke Stanley T (Chairman, President, CEO) Sale 6,535 11.06 72,309
2009-12-30 Crooke Stanley T (Chairman, President, CEO) Option Ex 6,535 6.81 44,503
2009-12-28 Parshall B Lynne (Director, COO) Sale 2,000 11.17 22,340
2009-12-28 Parshall B Lynne (Director, COO) Option Ex 2,000 6.81 13,626
2009-12-23 Parshall B Lynne (Director, COO) Sale 16,910 10.59 179,076
2009-12-23 Parshall B Lynne (Director, COO) Option Ex 16,910 6.81 115,207
2009-12-22 Parshall B Lynne (Director, COO) Sale 10,000 10.13 101,300
2009-12-22 Parshall B Lynne (Director, COO) Option Ex 10,000 6.81 68,130
2009-12-22 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 10.13 202,600
2009-12-22 Crooke Stanley T (Chairman, President, CEO) Option Ex 20,000 6.81 136,260
2009-12-16 Crooke Stanley T (Chairman, President, CEO) Sale 23,465 10.11 237,113
2009-12-16 Crooke Stanley T (Chairman, President, CEO) Option Ex 23,465 6.81 159,867
2009-12-15 Bennett C Frank (Senior Vice President) Sale 1,000 10.03 10,030
2009-12-15 Bennett C Frank (Senior Vice President) Option Ex 1,000 6.25 6,250
2009-12-15 Parshall B Lynne (Director, COO) Sale 10,000 10.03 100,300
2009-12-15 Parshall B Lynne (Director, COO) Option Ex 10,000 6.81 68,130
2009-12-15 Crooke Stanley T (Chairman, President, CEO) Sale 26,535 10.03 266,146
2009-12-15 Crooke Stanley T (Chairman, President, CEO) Option Ex 26,535 6.81 180,782
2009-12-14 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 9.86 197,200
2009-12-14 Crooke Stanley T (Chairman, President, CEO) Option Ex 20,000 6.81 136,260
2009-12-11 Parshall B Lynne (Director, COO) Sale 10,000 9.98 99,800
2009-12-11 Parshall B Lynne (Director, COO) Option Ex 10,000 6.81 68,130
2009-12-11 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 9.98 199,600
2009-12-11 Crooke Stanley T (Chairman, President, CEO) Option Ex 20,000 6.81 136,260
2009-12-10 Parshall B Lynne (Director, COO) Sale 13,000 10.15 131,950
2009-12-10 Parshall B Lynne (Director, COO) Option Ex 13,000 6.81 88,569
2009-12-10 Crooke Stanley T (Chairman, President, CEO) Sale 30,000 10.15 304,500
2009-12-10 Crooke Stanley T (Chairman, President, CEO) Option Ex 30,000 6.81 204,390
2009-12-09 Parshall B Lynne (Director, COO) Sale 10,000 10.26 102,600
2009-12-09 Parshall B Lynne (Director, COO) Option Ex 10,000 6.81 68,120
2009-12-09 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 10.26 205,200
2009-12-09 Crooke Stanley T (Chairman, President, CEO) Option Ex 20,000 6.81 136,240
2009-12-08 Parshall B Lynne (Director, COO) Sale 20,000 10.53 210,600
2009-12-08 Parshall B Lynne (Director, COO) Option Ex 20,000 6.81 136,240
2009-12-08 Crooke Stanley T (Chairman, President, CEO) Sale 30,000 10.53 315,900
2009-12-08 Crooke Stanley T (Chairman, President, CEO) Option Ex 30,000 6.81 204,360
2009-12-07 Parshall B Lynne (Director, COO) Sale 25,000 10.52 263,000
2009-12-07 Parshall B Lynne (Director, COO) Option Ex 25,000 6.81 170,300
2009-12-07 Crooke Stanley T (Chairman, President, CEO) Sale 30,000 10.52 315,600
2009-12-07 Crooke Stanley T (Chairman, President, CEO) Option Ex 30,000 6.81 204,360
2009-12-04 Parshall B Lynne (Director, COO) Sale 20,000 10.55 211,000
2009-12-04 Parshall B Lynne (Director, COO) Option Ex 20,000 6.81 136,240
2009-12-04 Crooke Stanley T (Chairman, President, CEO) Sale 30,000 10.55 316,500
2009-12-04 Crooke Stanley T (Chairman, President, CEO) Option Ex 30,000 6.81 204,360
2009-07-23 Bennett C Frank (Senior Vice President) Sale 12,000 17.03 204,312
2009-07-23 Bennett C Frank (Senior Vice President) Option Ex 12,000 6.81 81,720
2009-07-06 Parshall B Lynne (Director, COO) Sale 876 15.71 13,761
2009-07-02 Geary Richard S (Senior Vice President) Sale 2,322 15.89 36,888
2009-04-22 Bennett C Frank (Senior Vice President) Sale 10,000 15.92 159,200
2009-04-22 Bennett C Frank (Senior Vice President) Option Ex 10,000 6.81 68,100
2009-04-07 Bennett C Frank (Senior Vice President) Sale 10,000 14.60 146,030
2009-04-07 Bennett C Frank (Senior Vice President) Option Ex 10,000 6.81 68,100
2009-01-05 Parshall B Lynne (Director, COO) Sale 1,949 14.20 27,675
2009-01-02 Geary Richard S (Senior Vice President) Sale 1,415 14.05 19,886
2008-12-30 Parshall B Lynne (Director, COO) Sale 5,000 13.37 66,845
2008-12-30 Parshall B Lynne (Director, COO) Option Ex 5,000 12.94 64,685
2008-12-30 Crooke Stanley T (Chairman, President, CEO) Sale 7,500 13.37 100,267
2008-12-30 Crooke Stanley T (Chairman, President, CEO) Option Ex 7,500 12.94 97,027

Insider trading activities including stock purchases, stock sales, and option exercises of IONS listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Isis Pharmaceuticals Inc (symbol IONS, CIK number 874015) see the Securities and Exchange Commission (SEC) website.