Insider Trading activities of Isis Pharmaceuticals Inc insiders. , Part 6

Monthly summaries of insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Isis Pharmaceuticals Inc since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Isis Pharmaceuticals Inc since year 2005. (See page 1 of this report.) Table 2 shows the detailed insider transactions of Isis Pharmaceuticals Inc since 2005. The reporting company's ticker symbol is IONS. The reporting company's CIK number is 874015.
The total value of stock buying since 2005 is $90,940.
The total value of stock sales since 2005 is $141,567,829.
The total value of stock option exercises since 2005 is $46,177,849.



Table 2. Detailed insider stock purchases, sales, and option exercises of Isis Pharmaceuticals Inc insiders (IONS) , Part 6
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2008-12-23 Parshall B Lynne (Director, COO) Sale 7,000 13.52 94,633
2008-12-23 Parshall B Lynne (Director, COO) Option Ex 7,000 12.94 90,559
2008-12-23 Crooke Stanley T (Chairman, President, CEO) Sale 9,800 13.52 132,486
2008-12-23 Crooke Stanley T (Chairman, President, CEO) Option Ex 9,800 12.94 126,782
2008-12-19 Parshall B Lynne (Director, COO) Sale 8,000 13.93 111,408
2008-12-19 Parshall B Lynne (Director, COO) Option Ex 8,000 12.94 103,496
2008-12-19 Crooke Stanley T (Chairman, President, CEO) Sale 13,000 13.93 181,038
2008-12-19 Crooke Stanley T (Chairman, President, CEO) Option Ex 13,000 12.94 168,181
2008-12-17 Crooke Stanley T (Chairman, President, CEO) Sale 12,173 12.80 155,850
2008-12-17 Crooke Stanley T (Chairman, President, CEO) Option Ex 12,173 5.15 62,690
2008-09-02 Ecker David J (Vice President) Sale 10,000 18.11 181,119
2008-09-02 Ecker David J (Vice President) Option Ex 10,000 6.81 68,100
2008-08-22 Ecker David J (Vice President) Sale 10,000 18.04 180,380
2008-08-22 Ecker David J (Vice President) Option Ex 10,000 6.81 68,100
2008-08-20 Bennett C Frank (Senior Vice President) Sale 6,000 17.97 107,820
2008-08-20 Bennett C Frank (Senior Vice President) Option Ex 6,000 6.81 40,860
2008-08-15 Bennett C Frank (Senior Vice President) Sale 1,000 19.25 19,250
2008-08-15 Bennett C Frank (Senior Vice President) Option Ex 1,000 6.25 6,250
2008-08-14 Bennett C Frank (Senior Vice President) Sale 7,000 19.25 134,785
2008-08-14 Bennett C Frank (Senior Vice President) Option Ex 7,000 6.25 43,750
2008-08-11 Treble Michael J (Vice President, Pres of Ibis) Sale 20,000 18.45 369,060
2008-08-11 Treble Michael J (Vice President, Pres of Ibis) Option Ex 20,000 5.95 119,000
2008-08-11 Klein Joseph Iii (Director) Sale 10,000 18.60 185,960
2008-08-11 Ecker David J (Vice President) Sale 15,000 18.29 274,335
2008-08-11 Ecker David J (Vice President) Option Ex 15,000 5.80 87,000
2008-08-11 Bennett C Frank (Senior Vice President) Sale 15,000 18.28 274,170
2008-08-11 Bennett C Frank (Senior Vice President) Option Ex 15,000 12.94 194,055
2008-07-03 Parshall B Lynne (Director, COO) Sale 1,338 13.91 18,615
2008-07-03 Wender Joseph H (Director) Sale 4,000 13.94 55,760
2008-06-30 Wender Joseph H (Director) Option Ex 4,000 13.25 53,000
2008-04-10 Ecker David J (Vice President) Sale 5,300 16.04 85,022
2008-04-10 Ecker David J (Vice President) Option Ex 5,300 6.84 36,252
2008-04-07 Ecker David J (Vice President) Sale 12,200 16.06 195,980
2008-04-07 Ecker David J (Vice President) Option Ex 12,200 6.32 77,104
2008-04-01 Bennett C Frank (Senior Vice President) Sale 10,000 15.33 153,300
2008-04-01 Bennett C Frank (Senior Vice President) Option Ex 10,000 5.25 52,500
2008-01-08 Parshall B Lynne (Director, COO) Sale 2,406 19.28 46,387
2007-12-28 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 16.22 324,420
2007-12-28 Crooke Stanley T (Chairman, President, CEO) Option Ex 20,000 12.31 246,240
2007-12-27 Crooke Stanley T (Chairman, President, CEO) Sale 6,000 16.32 97,926
2007-12-27 Crooke Stanley T (Chairman, President, CEO) Option Ex 8,100 12.31 99,727
2007-12-26 Crooke Stanley T (Chairman, President, CEO) Sale 24,000 16.52 396,599
2007-12-26 Crooke Stanley T (Chairman, President, CEO) Option Ex 24,000 12.31 295,488
2007-12-11 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 17.37 347,480
2007-12-11 Crooke Stanley T (Chairman, President, CEO) Option Ex 20,000 12.31 246,240
2007-11-30 Crooke Stanley T (Chairman, President, CEO) Sale 29,851 18.03 538,153
2007-11-30 Crooke Stanley T (Chairman, President, CEO) Option Ex 29,851 5.15 153,732
2007-11-28 Parshall B Lynne (Executive Vice President) Sale 20,000 18.01 360,220
2007-11-28 Parshall B Lynne (Executive Vice President) Option Ex 20,000 6.81 136,240
2007-11-28 Crooke Stanley T (Chairman, President, CEO) Sale 30,000 18.01 540,330
2007-11-28 Crooke Stanley T (Chairman, President, CEO) Option Ex 30,000 5.15 154,500
2007-10-01 Parshall B Lynne (Executive Vice President) Sale 20,000 15.23 304,660
2007-10-01 Parshall B Lynne (Executive Vice President) Option Ex 20,000 12.31 246,240
2007-09-28 Parshall B Lynne (Executive Vice President) Sale 5,000 15.03 75,160
2007-09-28 Parshall B Lynne (Executive Vice President) Option Ex 5,000 12.31 61,560
2007-09-27 Parshall B Lynne (Executive Vice President) Sale 20,000 15.27 305,480
2007-09-27 Parshall B Lynne (Executive Vice President) Option Ex 20,000 12.31 246,240
2007-09-21 Treble Michael J (Vice President, Head of Ibis) Sale 10,000 14.95 149,500
2007-09-21 Treble Michael J (Vice President, Head of Ibis) Option Ex 10,000 5.95 59,500
2007-09-20 Bennett C Frank (Vice President) Sale 14,000 14.76 206,570
2007-09-20 Bennett C Frank (Vice President) Option Ex 14,000 12.31 172,368
2007-09-18 Ecker David J (Vice President) Sale 6,000 14.13 84,780
2007-09-18 Ecker David J (Vice President) Option Ex 6,000 6.81 40,860
2007-09-14 Treble Michael J (Vice President, Head of Ibis) Sale 10,000 13.96 139,600
2007-09-14 Treble Michael J (Vice President, Head of Ibis) Option Ex 10,000 5.95 59,500
2007-09-14 Ecker David J (Vice President) Sale 24,000 14.12 338,832
2007-09-14 Ecker David J (Vice President) Option Ex 24,000 6.81 163,440
2007-09-14 Bennett C Frank (Vice President) Sale 10,000 13.76 137,600
2007-09-14 Bennett C Frank (Vice President) Option Ex 10,000 5.15 51,500
2007-09-11 Parshall B Lynne (Executive Vice President) Sale 6,466 13.03 84,251
2007-09-11 Parshall B Lynne (Executive Vice President) Option Ex 6,466 5.15 33,299
2007-08-21 Bennett C Frank (Vice President) Sale 10,000 12.50 125,000
2007-08-21 Bennett C Frank (Vice President) Option Ex 10,000 6.25 62,500
2007-07-12 Treble Michael J (Vice President, Head of Ibis) Sale 10,000 11.95 119,500
2007-07-12 Treble Michael J (Vice President, Head of Ibis) Option Ex 10,000 5.95 59,500
2007-07-10 Treble Michael J (Vice President, Head of Ibis) Sale 10,000 11.95 119,500
2007-07-10 Treble Michael J (Vice President, Head of Ibis) Option Ex 10,000 5.25 52,500
2007-07-09 Bennett C Frank (Vice President) Sale 5,732 10.78 61,813
2007-07-09 Bennett C Frank (Vice President) Option Ex 4,599 5.15 23,684
2007-07-06 Wedel Mark K (VP & Chief Medical Officer) Sale 5,200 10.12 52,623
2007-07-06 Wedel Mark K (VP & Chief Medical Officer) Option Ex 5,200 5.53 28,730
2007-07-03 Parshall B Lynne (Executive Vice President) Sale 835 9.85 8,224
2007-07-02 Wedel Mark K (VP & Chief Medical Officer) Sale 902 9.70 8,751
2007-05-09 Wedel Mark K (VP & Chief Medical Officer) Sale 2,800 10.36 29,019
2007-05-09 Wedel Mark K (VP & Chief Medical Officer) Option Ex 2,800 5.15 14,420
2007-05-02 Wedel Mark K (VP & Chief Medical Officer) Sale 2,000 10.25 20,500
2007-05-02 Wedel Mark K (VP & Chief Medical Officer) Option Ex 2,000 5.15 10,300
2007-04-25 Wedel Mark K (VP & Chief Medical Officer) Sale 13,711 10.11 138,618
2007-04-25 Wedel Mark K (VP & Chief Medical Officer) Option Ex 10,000 4.59 45,950
2007-04-25 Levin Arthur A (Vice President) Sale 6,000 10.11 60,660
2007-04-25 Levin Arthur A (Vice President) Option Ex 6,000 5.25 31,500
2006-12-08 Ecker David J (Vice President) Sale 11,100 12.04 133,599
2006-12-08 Ecker David J (Vice President) Option Ex 11,100 6.81 75,591
2006-12-04 Ecker David J (Vice President) Sale 5,000 11.50 57,485
2006-12-04 Ecker David J (Vice President) Option Ex 5,000 6.81 34,050
2006-11-14 Ecker David J (Vice President) Sale 3,900 12.11 47,209
2006-11-14 Ecker David J (Vice President) Option Ex 3,900 6.81 26,559
2006-11-13 Levin Arthur A (Vice President) Sale 30,000 13.36 400,800
2006-11-13 Levin Arthur A (Vice President) Option Ex 30,000 6.81 204,300
2006-11-13 Ecker David J (Vice President) Sale 20,000 13.36 267,200
2006-11-13 Ecker David J (Vice President) Option Ex 10,000 6.81 68,100
2006-11-13 Bennett C Frank (Vice President) Sale 10,000 13.36 133,600
2006-11-13 Bennett C Frank (Vice President) Option Ex 10,000 5.15 51,500
2006-11-13 Parshall B Lynne (Executive Vice President) Sale 30,000 13.36 400,800
2006-11-13 Parshall B Lynne (Executive Vice President) Option Ex 30,000 5.15 154,500
2006-11-13 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 13.36 267,200
2006-11-10 Ecker David J (Vice President) Sale 6,788 10.40 70,629
2006-11-10 Ecker David J (Vice President) Option Ex 6,788 5.15 34,958
2006-11-10 Crooke Stanley T (Chairman, President, CEO) Sale 10,000 10.40 104,050
2006-11-09 Levin Arthur A (Vice President) Sale 20,000 10.13 202,600
2006-11-09 Levin Arthur A (Vice President) Option Ex 20,000 6.81 136,200
2006-11-09 Ecker David J (Vice President) Sale 20,000 10.13 202,600
2006-11-09 Ecker David J (Vice President) Option Ex 20,000 5.15 103,000
2006-11-09 Bennett C Frank (Vice President) Sale 10,000 10.13 101,300
2006-11-09 Bennett C Frank (Vice President) Option Ex 10,000 5.15 51,500
2006-11-09 Parshall B Lynne (Executive Vice President) Sale 20,000 10.13 202,600
2006-11-09 Parshall B Lynne (Executive Vice President) Option Ex 20,000 5.15 103,000
2006-11-09 Crooke Stanley T (Chairman, President, CEO) Sale 20,000 10.13 202,600
2006-10-19 Levin Arthur A (Vice President) Sale 12,424 8.98 111,567
2006-10-19 Levin Arthur A (Vice President) Option Ex 12,424 5.47 68,021
2006-10-06 Levin Arthur A (Vice President) Sale 10,000 7.97 79,730
2006-10-06 Levin Arthur A (Vice President) Option Ex 10,000 5.15 51,500
2006-08-15 Klein Joseph Iii (Director) Buy 2,000 6.26 12,520
2006-08-01 Klein Joseph Iii (Director) Buy 2,000 6.00 12,000
2006-07-18 Klein Joseph Iii (Director) Buy 2,000 5.91 11,820
2006-07-03 Klein Joseph Iii (Director) Buy 2,000 6.02 12,040
2006-05-05 Bennett C Frank (Vice President) Sale 8,500 8.55 72,658
2006-05-05 Bennett C Frank (Vice President) Option Ex 8,500 5.80 49,300
2006-03-21 Levin Arthur A (Vice President) Sale 500 9.04 4,517
2006-03-21 Levin Arthur A (Vice President) Option Ex 500 6.84 3,420
2006-03-21 Ecker David J (Vice President) Sale 12,756 9.03 115,237
2006-03-21 Ecker David J (Vice President) Option Ex 12,756 5.15 65,693
2006-03-20 Levin Arthur A (Vice President) Sale 9,500 9.04 85,918
2006-03-20 Levin Arthur A (Vice President) Option Ex 9,500 6.84 64,980
2006-03-20 Ecker David J (Vice President) Sale 14,032 8.96 125,726
2006-03-20 Ecker David J (Vice President) Option Ex 14,032 5.15 72,264
2006-03-08 Brown Richard K (Vice President) Sale 2,770 8.07 22,359
2006-03-08 Brown Richard K (Vice President) Option Ex 2,770 6.84 18,946
2006-03-07 Brown Richard K (Vice President) Sale 2,000 7.97 15,940
2006-03-07 Brown Richard K (Vice President) Option Ex 2,000 6.84 13,680
2006-03-03 Brown Richard K (Vice President) Sale 1,008 8.23 8,295
2006-03-03 Brown Richard K (Vice President) Option Ex 1,008 6.84 6,894
2006-03-02 Brown Richard K (Vice President) Sale 3,600 8.19 29,494
2006-03-02 Brown Richard K (Vice President) Option Ex 3,600 6.84 24,624
2006-03-01 Brown Richard K (Vice President) Sale 6,000 8.09 48,510
2006-03-01 Brown Richard K (Vice President) Option Ex 6,000 6.83 40,950
2006-02-28 Brown Richard K (Vice President) Sale 2,000 8.01 16,020
2006-02-28 Brown Richard K (Vice President) Option Ex 2,000 6.81 13,620
2006-02-27 Brown Richard K (Vice President) Sale 3,715 8.10 30,098
2006-02-27 Brown Richard K (Vice President) Option Ex 3,715 6.81 25,299
2006-02-24 Brown Richard K (Vice President) Sale 1,000 8.02 8,020
2006-02-24 Brown Richard K (Vice President) Option Ex 1,000 6.81 6,810
2006-02-22 Brown Richard K (Vice President) Sale 1,185 7.88 9,337
2006-02-22 Brown Richard K (Vice President) Option Ex 1,185 5.80 6,873
2006-02-21 Brown Richard K (Vice President) Sale 3,100 8.06 24,986
2006-02-21 Brown Richard K (Vice President) Option Ex 3,100 5.80 17,980
2006-02-17 Levin Arthur A (Vice President) Sale 7,770 8.03 62,393
2006-02-17 Levin Arthur A (Vice President) Option Ex 7,770 5.15 40,015
2006-02-17 Brown Richard K (Vice President) Sale 12,000 8.11 97,260
2006-02-17 Brown Richard K (Vice President) Option Ex 12,000 5.47 65,700
2006-02-17 Ecker David J (Vice President) Sale 26,789 8.02 214,874
2006-02-17 Ecker David J (Vice President) Option Ex 26,789 5.15 137,963
2006-02-16 Levin Arthur A (Vice President) Sale 3,000 7.95 23,850
2006-02-16 Levin Arthur A (Vice President) Option Ex 3,000 5.15 15,450
2006-02-09 Bennett C Frank (Vice President) Sale 1,500 6.50 9,750
2006-02-01 Klein Joseph Iii (Director) Buy 2,000 5.48 10,960
2006-01-17 Klein Joseph Iii (Director) Buy 2,000 5.46 10,920
2006-01-03 Klein Joseph Iii (Director) Buy 2,000 5.16 10,320
2005-12-15 Klein Joseph Iii (Director) Buy 2,000 5.18 10,360
2005-09-19 Parshall B Lynne (Executive Vice Presi) Sale 1,450 5.32 7,711
2005-09-15 Parshall B Lynne (Executive Vice Presi) Sale 1,558 5.28 8,223
2005-09-12 Parshall B Lynne (Executive Vice Presi) Sale 2,700 5.46 14,728
2005-06-24 Parshall B Lynne (Executive Vice Presi) Sale 4,446 4.00 17,806

Insider trading activities including stock purchases, stock sales, and option exercises of IONS listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Isis Pharmaceuticals Inc (symbol IONS, CIK number 874015) see the Securities and Exchange Commission (SEC) website.