Insider Trading activities of Ionis Pharmaceuticals Inc insiders.

Monthly summaries of insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Ionis Pharmaceuticals Inc since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Ionis Pharmaceuticals Inc since year 2005. Table 2 shows the detailed insider transactions of Ionis Pharmaceuticals Inc since 2005. The reporting company's ticker symbol is IONS. The reporting company's CIK number is 874015.
The total value of stock buying since 2005 is $90,940.
The total value of stock sales since 2005 is $144,137,229.
The total value of stock option exercises since 2005 is $46,926,894.


Table 1. Monthly summaries of insider stock purchases, sales, and option exercises for Ionis Pharmaceuticals Inc (IONS).
Trading Period Insider Buying Insider Sales Option Exercises
year-month Shares Value Shares Value Shares Value
2017-11 0 $0 13,250 $725,480 13,062 $183,294
2017-10 0 $0 81,636 $4,830,565 80,829 $1,122,898
2017-09 0 $0 1,000 $55,000 1,000 $7,250
2017-07 0 $0 54,309 $2,943,682 69,283 $565,119
2017-06 0 $0 70 $3,360 70 $757
2017-05 0 $0 13,150 $596,937 13,000 $127,535
2017-04 0 $0 45,500 $1,984,379 44,500 $352,273
2017-03 0 $0 23,225 $1,194,467 22,225 $230,917
2017-02 0 $0 1,500 $69,502 13,937 $126,642
2017-01 0 $0 68,656 $3,266,572 111,652 $279,763
2016-12 0 $0 19,480 $866,822 19,350 $244,587
2016-11 0 $0 69,305 $2,616,999 69,305 $718,181
2016-10 0 $0 11,000 $402,710 11,000 $113,189
2016-09 0 $0 56,500 $1,947,931 56,500 $589,883
2016-07 0 $0 0 $0 12,534 $0
2016-05 0 $0 12,500 $278,900 12,500 $74,125
2016-04 0 $0 12,000 $552,375 12,000 $124,009
2016-03 0 $0 12,000 $493,485 12,000 $121,062
2016-02 0 $0 0 $0 13,438 $74,125
2016-01 0 $0 48,151 $2,363,315 84,145 $181,876
2015-12 0 $0 8,909 $515,544 8,909 $121,693
2015-11 0 $0 17,875 $1,093,187 17,875 $228,400
2015-10 0 $0 56,436 $2,440,275 56,436 $607,924
2015-07 0 $0 24,984 $1,430,987 33,319 $245,038
2015-06 0 $0 17,600 $1,172,389 17,600 $117,704
2015-04 0 $0 54,942 $3,434,492 64,942 $651,016
2015-03 0 $0 154,514 $11,140,929 147,499 $1,822,552
2015-02 0 $0 10,000 $621,460 10,938 $39,500
2015-01 0 $0 77,697 $5,304,967 100,697 $628,856
2014-12 0 $0 1,500 $76,815 1,500 $10,875
2014-11 0 $0 1,500 $69,255 1,500 $10,875
2014-10 0 $0 63,171 $2,559,956 63,171 $726,171
2014-09 0 $0 12,571 $506,183 12,571 $112,526
2014-08 0 $0 66,944 $2,392,807 66,944 $780,915
2014-07 0 $0 19,243 $683,664 23,535 $249,986
2014-06 0 $0 44,700 $1,504,547 44,700 $561,078
2014-04 0 $0 10,300 $450,702 20,300 $196,536
2014-03 0 $0 1,500 $74,550 1,500 $16,455
2014-02 0 $0 6,200 $304,956 11,500 $74,105
2014-01 0 $0 200,161 $9,331,794 204,046 $1,972,297
2013-12 0 $0 137,542 $5,630,883 132,811 $1,693,629
2013-11 0 $0 16,000 $587,494 0 $0
2013-09 0 $0 379,641 $12,660,157 327,656 $4,548,129
2013-08 0 $0 21,659 $603,584 18,750 $216,937
2013-07 0 $0 412,827 $12,461,933 351,978 $4,752,494
2013-06 0 $0 192,554 $5,095,517 157,107 $1,529,655
2013-05 0 $0 39,945 $886,205 39,945 $320,156
2013-04 0 $0 380,249 $8,147,219 330,249 $3,442,004
2013-03 0 $0 158,453 $2,814,983 158,453 $1,516,129
2013-02 0 $0 8,189 $117,269 18,050 $118,277
2013-01 0 $0 7,859 $105,503 10,302 $20,580
2012-12 0 $0 6,000 $57,750 6,000 $31,500
2012-09 0 $0 288,073 $4,253,922 288,073 $1,630,541
2012-07 0 $0 35,207 $474,811 32,186 $182,053
2012-06 0 $0 21,579 $243,197 30,000 $244,500
2012-05 0 $0 20,000 $190,817 20,000 $187,999
2011-12 0 $0 123,462 $847,269 123,462 $1,446,137
2011-08 0 $0 10,000 $76,210 10,000 $52,500
2011-07 0 $0 1,000 $8,600 0 $0
2010-12 0 $0 104,330 $1,088,291 113,030 $1,091,800
2010-07 0 $0 1,100 $10,560 0 $0
2010-06 0 $0 10,000 $98,948 10,000 $58,000
2009-12 0 $0 407,535 $4,210,532 417,535 $2,843,866
2009-07 0 $0 17,133 $285,701 12,000 $81,720
2009-04 0 $0 20,000 $305,230 20,000 $136,200
2009-01 0 $0 3,364 $47,561 0 $0
2008-12 0 $0 74,973 $1,008,152 74,973 $875,132
2008-09 0 $0 10,000 $181,119 10,000 $68,100
2008-08 0 $0 84,000 $1,545,760 74,000 $559,015
2008-07 0 $0 5,338 $74,375 0 $0
2008-06 0 $0 0 $0 4,000 $53,000
2008-04 0 $0 27,500 $434,302 27,500 $165,856
2008-01 0 $0 2,406 $46,387 0 $0
2007-12 0 $0 70,000 $1,166,425 72,100 $887,695
2007-11 0 $0 79,851 $1,438,703 79,851 $444,472
2007-10 0 $0 20,000 $304,660 20,000 $246,240
2007-09 0 $0 105,466 $1,521,773 105,466 $888,267
2007-08 0 $0 10,000 $125,000 10,000 $62,500
2007-07 0 $0 32,669 $370,411 29,799 $164,414
2007-05 0 $0 4,800 $49,519 4,800 $24,720
2007-04 0 $0 19,711 $199,278 16,000 $77,450
2006-12 0 $0 16,100 $191,084 16,100 $109,641
2006-11 0 $0 220,688 $2,603,188 160,688 $933,617
2006-10 0 $0 22,424 $191,297 22,424 $119,521
2006-08 4,000 $24,520 0 $0 0 $0
2006-07 4,000 $23,860 0 $0 0 $0
2006-05 0 $0 8,500 $72,658 8,500 $49,300
2006-03 0 $0 52,166 $455,996 52,166 $311,451
2006-02 2,000 $10,960 62,059 $496,588 60,559 $329,710
2006-01 4,000 $21,240 0 $0 0 $0
2005-12 2,000 $10,360 0 $0 0 $0
2005-09 0 $0 5,708 $30,662 0 $0
2005-06 0 $0 4,446 $17,806 0 $0

Table 2. Detailed insider stock purchases, sales, and option exercises of Ionis Pharmaceuticals Inc insiders (IONS)
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2017-11-16 Klein Joseph Iii (Director) Option Ex 2,812 12.94 36,387
2017-11-16 Hougen Elizabeth L (SVP, Finance & CFO) Sale 7,000 54.35 380,450
2017-11-16 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 7,000 10.29 72,030
2017-11-15 Klein Joseph Iii (Director) Sale 2,250 53.56 120,510
2017-11-15 Klein Joseph Iii (Director) Option Ex 2,250 28.47 64,057
2017-11-13 Klein Joseph Iii (Director) Sale 3,000 55.39 166,170
2017-11-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 58.35 58,350
2017-11-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2017-10-18 Bennett C Frank (SVP, Antisense Research) Sale 12,250 65.00 796,250
2017-10-18 Bennett C Frank (SVP, Antisense Research) Option Ex 12,250 10.29 126,052
2017-10-18 Parshall B Lynne (COO) Sale 16,118 65.00 1,047,670
2017-10-18 Parshall B Lynne (COO) Option Ex 16,118 27.28 439,699
2017-10-13 Geary Richard S (SVP, Development) Sale 8,268 60.00 496,080
2017-10-13 Geary Richard S (SVP, Development) Option Ex 7,461 8.77 65,432
2017-10-13 Crooke Stanley T (Chairman and CEO) Sale 16,500 59.46 981,090
2017-10-13 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 10.97 181,005
2017-10-05 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 55.00 55,000
2017-10-05 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 9.04 9,035
2017-10-04 Crooke Stanley T (Chairman and CEO) Sale 11,000 54.23 596,475
2017-10-04 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.97 120,670
2017-10-02 Crooke Stanley T (Chairman and CEO) Sale 16,500 52.00 858,000
2017-10-02 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 10.97 181,005
2017-09-06 O'neil Patrick R. (SVP, Legal and General Counsel) Sale 800 55.00 44,000
2017-09-06 O'neil Patrick R. (SVP, Legal and General Counsel) Option Ex 800 7.25 5,800
2017-09-05 O'neil Patrick R. (SVP, Legal and General Counsel) Sale 200 55.00 11,000
2017-09-05 O'neil Patrick R. (SVP, Legal and General Counsel) Option Ex 200 7.25 1,450
2017-07-24 Bennett C Frank (SVP, Antisense Research) Sale 10,000 59.29 592,900
2017-07-24 Bennett C Frank (SVP, Antisense Research) Option Ex 10,000 10.29 102,899
2017-07-20 Crooke Stanley T (Chairman and CEO) Sale 11,000 55.35 608,850
2017-07-20 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.97 120,670
2017-07-17 Crooke Stanley T (Chairman and CEO) Sale 16,500 52.45 865,425
2017-07-17 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 10.97 181,005
2017-07-03 Monia Brett P (SVP, Antisense Drug Discovery) Sale 309 51.35 15,867
2017-07-03 Crooke Stanley T (Chairman and CEO) Sale 16,500 52.16 860,640
2017-07-03 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 9.73 160,545
2017-07-02 Klein Joseph Iii (Director) Option Ex 2,469 .00 0
2017-07-01 Castleman Breaux (Director) Option Ex 3,406 .00 0
2017-07-01 Loscalzo Joseph (Director) Option Ex 2,001 .00 0
2017-07-01 Muto Frederick T (Director) Option Ex 2,469 .00 0
2017-07-01 Berthelsen Spencer R (Director) Option Ex 2,469 .00 0
2017-07-01 Wender Joseph H (Director) Option Ex 2,469 .00 0
2017-06-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 70 48.00 3,360
2017-06-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 70 10.82 757
2017-05-31 Muto Frederick T (Director) Sale 12,500 45.22 565,250
2017-05-31 Muto Frederick T (Director) Option Ex 12,500 9.77 122,125
2017-05-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 650 48.75 31,687
2017-05-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 500 10.82 5,410
2017-04-25 Crooke Stanley T (Chairman and CEO) Sale 16,500 47.81 788,865
2017-04-25 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 7.25 119,625
2017-04-24 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 500 45.00 22,500
2017-04-24 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 500 10.82 5,410
2017-04-19 Crooke Stanley T (Chairman and CEO) Sale 5,500 43.25 237,875
2017-04-19 Crooke Stanley T (Chairman and CEO) Option Ex 5,500 7.25 39,875
2017-04-13 Crooke Stanley T (Chairman and CEO) Sale 11,000 41.30 454,299
2017-04-13 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.26 90,893
2017-04-12 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 40.07 40,070
2017-04-12 Crooke Stanley T (Chairman and CEO) Sale 11,000 40.07 440,770
2017-04-12 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.77 96,470
2017-03-03 Bennett C Frank (SVP, Antisense Research) Sale 5,000 55.00 275,000
2017-03-03 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 10.29 51,449
2017-03-02 Crooke Stanley T (Chairman and CEO) Sale 12,100 51.05 617,705
2017-03-02 Crooke Stanley T (Chairman and CEO) Option Ex 12,100 8.77 106,117
2017-03-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,500 49.29 73,935
2017-03-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 500 10.82 5,410
2017-03-01 Parshall B Lynne (COO) Sale 4,625 49.26 227,827
2017-03-01 Parshall B Lynne (COO) Option Ex 4,625 14.69 67,941
2017-02-24 Berthelsen Spencer R (Director) Option Ex 12,500 9.77 122,125
2017-02-06 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,500 46.34 69,502
2017-02-06 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 500 9.04 4,517
2017-02-03 Loscalzo Joseph (Director) Option Ex 937 .00 0
2017-01-17 Boyce Sarah (Chief Business Officer) Sale 1,361 46.29 63,000
2017-01-17 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 2,246 46.29 103,969
2017-01-17 Monia Brett P (SVP, Antisense Drug Discovery) Sale 2,502 46.29 115,817
2017-01-17 Geary Richard S (SVP, Development) Sale 2,441 46.29 112,996
2017-01-17 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,273 46.29 105,219
2017-01-17 Bennett C Frank (SVP, Antisense Research) Sale 2,421 46.29 112,068
2017-01-17 Parshall B Lynne (COO) Sale 7,246 46.29 335,417
2017-01-17 Crooke Stanley T (Chairman and CEO) Sale 15,957 46.29 738,649
2017-01-15 Boyce Sarah (Chief Business Officer) Option Ex 3,483 .00 0
2017-01-15 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 5,745 .00 0
2017-01-15 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 6,402 .00 0
2017-01-15 Geary Richard S (SVP, Development) Option Ex 6,246 .00 0
2017-01-15 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 5,814 .00 0
2017-01-15 Bennett C Frank (SVP, Antisense Research) Option Ex 6,195 .00 0
2017-01-15 Parshall B Lynne (COO) Option Ex 16,033 .00 0
2017-01-15 Crooke Stanley T (Chairman and CEO) Option Ex 29,834 .00 0
2017-01-10 Crooke Stanley T (Chairman and CEO) Sale 13,200 49.25 650,100
2017-01-10 Crooke Stanley T (Chairman and CEO) Option Ex 13,200 8.77 115,764
2017-01-04 Crooke Stanley T (Chairman and CEO) Sale 7,700 50.10 385,770
2017-01-04 Crooke Stanley T (Chairman and CEO) Option Ex 7,700 8.77 67,529
2017-01-03 Monia Brett P (SVP, Antisense Drug Discovery) Sale 309 48.60 15,017
2017-01-03 Crooke Stanley T (Chairman and CEO) Sale 11,000 48.05 528,550
2017-01-03 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.77 96,470
2016-12-20 Monia Brett P (SVP, Antisense Drug Discovery) Sale 130 52.48 6,822
2016-12-15 Parshall B Lynne (COO) Sale 4,000 50.00 200,000
2016-12-15 Parshall B Lynne (COO) Option Ex 4,000 7.25 29,000
2016-12-05 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 350 45.00 15,750
2016-12-05 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 350 10.82 3,787
2016-12-05 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 46.05 115,125
2016-12-05 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-12-01 Parshall B Lynne (COO) Sale 12,500 42.33 529,125
2016-12-01 Parshall B Lynne (COO) Option Ex 12,500 14.69 183,625
2016-11-14 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.00 45,000
2016-11-14 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-11-14 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 47.50 118,750
2016-11-14 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-11 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 41.00 102,500
2016-11-11 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-10 Crooke Stanley T (Chairman and CEO) Sale 11,000 41.23 453,475
2016-11-10 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.77 96,470
2016-11-09 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 38.49 96,225
2016-11-09 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-09 Bennett C Frank (SVP, Antisense Research) Sale 22,805 36.31 828,049
2016-11-09 Bennett C Frank (SVP, Antisense Research) Option Ex 22,805 11.27 257,012
2016-11-09 Crooke Stanley T (Chairman and CEO) Sale 22,000 36.50 803,000
2016-11-09 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 9.68 213,004
2016-11-07 Bennett C Frank (SVP, Antisense Research) Sale 5,000 34.00 170,000
2016-11-07 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 11.27 56,350
2016-10-05 Crooke Stanley T (Chairman and CEO) Sale 11,000 36.61 402,710
2016-10-05 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.29 113,189
2016-09-27 Crooke Stanley T (Chairman and CEO) Sale 22,000 36.03 792,769
2016-09-27 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 10.29 226,379
2016-09-21 Crooke Stanley T (Chairman and CEO) Sale 22,000 35.50 781,000
2016-09-21 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 10.29 226,379
2016-09-01 Parshall B Lynne (COO) Sale 12,500 29.93 374,162
2016-09-01 Parshall B Lynne (COO) Option Ex 12,500 10.97 137,125
2016-07-02 Klein Joseph Iii (Director) Option Ex 312 .00 0
2016-07-02 Muto Frederick T (Director) Option Ex 312 .00 0
2016-07-02 Berthelsen Spencer R (Director) Option Ex 312 .00 0
2016-07-02 Wender Joseph H (Director) Option Ex 312 .00 0
2016-07-01 Castleman Breaux (Director) Option Ex 2,740 .00 0
2016-07-01 Loscalzo Joseph (Director) Option Ex 1,334 .00 0
2016-07-01 Klein Joseph Iii (Director) Option Ex 1,803 .00 0
2016-07-01 Muto Frederick T (Director) Option Ex 1,803 .00 0
2016-07-01 Berthelsen Spencer R (Director) Option Ex 1,803 .00 0
2016-07-01 Wender Joseph H (Director) Option Ex 1,803 .00 0
2016-05-31 Muto Frederick T (Director) Sale 12,500 22.31 278,900
2016-05-31 Muto Frederick T (Director) Option Ex 12,500 5.93 74,125
2016-04-06 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.00 45,000
2016-04-06 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-04-06 Crooke Stanley T (Chairman and CEO) Sale 11,000 46.12 507,375
2016-04-06 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.29 113,189
2016-03-31 Crooke Stanley T (Chairman and CEO) Sale 11,000 40.73 448,085
2016-03-31 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.02 110,242
2016-03-23 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.40 45,400
2016-03-23 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-02-19 Berthelsen Spencer R (Director) Option Ex 12,500 5.93 74,125
2016-02-03 Loscalzo Joseph (Director) Option Ex 938 .00 0
2016-01-19 Boyce Sarah (Chief Business Officer) Sale 872 41.46 36,150
2016-01-19 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,871 41.46 77,571

Insider trading activities including stock purchases, stock sales, and option exercises of IONS listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Ionis Pharmaceuticals Inc (symbol IONS, CIK number 874015) see the Securities and Exchange Commission (SEC) website.