- Company Directors - I
- Isaly Samuel D
Insider Trading History of Isaly Samuel D
The following table details the insider trading activities
(stock purchases, stock sales, and stock option exercises) by Isaly Samuel D since 2005.
The trader's CIK number is 1055949.
At the time of the last reporting, Isaly Samuel D was the Director of Kala Pharmaceuticals, Inc.. (stock ticker symbol KALA).
Also see all insider trading activities at Kala Pharmaceuticals, Inc..
Note that in the past
ISALY SAMUEL D also reported insider trading activities as an insider of the following companies:
Insider Activities at Kala Pharmaceuticals, Inc. (KALA)
Insider Activities at Pieris Pharmaceuticals, Inc. (PIRS)
Insider Activities at Loxo Oncology, Inc. (LOXO)
Insider Activities at Scpharmaceuticals Inc. (SCPH)
Insider Activities at Rhythm Pharmaceuticals, Inc. (RYTM)
Insider Activities at Roka Bioscience, Inc. (ROKA)
Insider Activities at Audentes Therapeutics, Inc. (BOLD)
Insider Activities at Glaukos Corp (GKOS)
Insider Activities at Steadymed Ltd. (STDY)
Insider Activities at Adaptimmune Therapeutics Plc (ADAP)
Insider Activities at Aerpio Pharmaceuticals, Inc. (ARPO)
Insider Activities at Aeglea Biotherapeutics, Inc. (AGLE)
Insider Activities at Viewray, Inc. (VRAY)
Insider Activities at Relypsa Inc (RLYP)
Insider Activities at Selecta Biosciences Inc (SELB)
Insider Activities at Corvus Pharmaceuticals, Inc. (CRVS)
Insider Activities at Intellia Therapeutics, Inc. (NTLA)
Insider Activities at Otonomy, Inc. (OTIC)
Insider Activities at Dimension Therapeutics, Inc. (DMTX)
Insider Activities at Sientra, Inc. (SIEN)
Insider Activities at Intercept Pharmaceuticals, Inc. (ICPT)
Insider Activities at Mirati Therapeutics, Inc. (MRTX)
Insider Activities at Ambit Biosciences Corp (AMBI)
Insider Activities at Anthera Pharmaceuticals Inc (ANTH)
Insider Activities at Amarin Corp Plc\uk (AMRN)
Insider Activities at Complete Genomics Inc (GNOM)
Insider Activities at Supernus Pharmaceuticals, Inc. (SUPN)
Insider Activities at Pacira Biosciences, Inc. (PCRX)
Insider Activities at Athersys, Inc / New (ATHX)
Insider Activities at Nxstage Medical, Inc. (NXTM)
Insider Activities at Albireo Pharma, Inc. (ALBO)
Insider Activities at Aryx Therapeutics, Inc. (ARYX)
Insider Activities at Cryocor Inc (CRYO)
Yearly summary of insider trading at Cryocor Inc (CRYO) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2005 | CRYO | 0 | $0 | 135,000 | $1,485,000 | 0 | $0 |
Yearly summary of insider trading at Adaptimmune Therapeutics Plc (ADAP) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | ADAP | 1,190,476 | $4,999,999 | 0 | $0 | 0 | $0 |
| 2016 | ADAP | 1,712,400 | $17,849,567 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Steadymed Ltd. (STDY) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | STDY | 1,174,000 | $6,926,600 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Aeglea Biotherapeutics, Inc. (AGLE) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | AGLE | 109,300 | $563,882 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Audentes Therapeutics, Inc. (BOLD) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | BOLD | 0 | $0 | 677,000 | $19,095,750 | 0 | $0 |
Yearly summary of insider trading at Selecta Biosciences Inc (SELB) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2016 | SELB | 1,100,000 | $15,400,000 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Kala Pharmaceuticals, Inc. (KALA) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2018 | KALA | 240,484 | $3,192,709 | 0 | $0 | 0 | $0 |
| 2017 | KALA | 319,333 | $4,789,995 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Loxo Oncology, Inc. (LOXO) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | LOXO | 0 | $0 | 787,000 | $60,739,620 | 0 | $0 |
| 2016 | LOXO | 0 | $0 | 447,857 | $12,074,224 | 0 | $0 |
| 2014 | LOXO | 275,385 | $3,580,005 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Nxstage Medical, Inc. (NXTM) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2010 | NXTM | 0 | $0 | 2,020,612 | $33,872,033 | 0 | $0 |
| 2008 | NXTM | 5,718,256 | $25,548,961 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Pieris Pharmaceuticals, Inc. (PIRS) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2018 | PIRS | 0 | $0 | 1,709,620 | $12,565,707 | 0 | $0 |
| 2017 | PIRS | 0 | $0 | 147,635 | $841,519 | 147,635 | $342,660 |
| 2015 | PIRS | 500,000 | $1,375,000 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Aerpio Pharmaceuticals, Inc. (NONE) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | NONE | 762,995 | $3,814,975 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Anthera Pharmaceuticals Inc (ANTH) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2013 | ANTH | 7,462,000 | $4,903,776 | 0 | $0 | 0 | $0 |
| 2012 | ANTH | 0 | $0 | 2,831,800 | $4,778,795 | 0 | $0 |
| 2011 | ANTH | 0 | $0 | 928,668 | $7,108,724 | 0 | $0 |
| 2010 | ANTH | 19,900 | $81,192 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Aryx Therapeutics, Inc. (ARYX) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2009 | ARYX | 0 | $0 | 2,000,000 | $8,000,000 | 0 | $0 |
| 2008 | ARYX | 1,214,646 | $0 | 0 | $0 | 0 | $0 |
| 2007 | ARYX | 300,000 | $3,000,000 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Glaukos Corp (GKOS) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | GKOS | 0 | $0 | 1,343,510 | $55,000,439 | 0 | $0 |
| 2016 | GKOS | 0 | $0 | 717,938 | $22,870,035 | 0 | $0 |
| 2015 | GKOS | 0 | $0 | 0 | $0 | 27,607 | $0 |
Yearly summary of insider trading at Intellia Therapeutics, Inc. (NTLA) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2016 | NTLA | 250,000 | $4,500,000 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Scpharmaceuticals Inc. (SCPH) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | SCPH | 833,333 | $11,666,662 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Athersys, Inc / New (ATHX) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2011 | ATHX | 0 | $0 | 189,400 | $551,978 | 0 | $0 |
| 2009 | ATHX | 162,200 | $126,330 | 0 | $0 | 0 | $0 |
| 2008 | ATHX | 448,000 | $1,075,200 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Ambit Biosciences Corp (AMBI) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2013 | AMBI | 714,271 | $5,417,792 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Rhythm Pharmaceuticals, Inc. (RYTM) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | RYTM | 355,000 | $6,035,000 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Mirati Therapeutics, Inc. (MRTX) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2015 | MRTX | 100,000 | $2,000,000 | 0 | $0 | 0 | $0 |
| 2014 | MRTX | 0 | $0 | 107,332 | $2,372,450 | 0 | $0 |
| 2013 | MRTX | 125,000 | $2,187,500 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Dimension Therapeutics, Inc. (DMTX) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2015 | DMTX | 200,000 | $2,600,000 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Albireo Pharma, Inc. (BIOD) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2009 | BIOD | 0 | $0 | 26,988 | $141,417 | 0 | $0 |
| 2008 | BIOD | 0 | $0 | 154,000 | $2,229,920 | 0 | $0 |
Yearly summary of insider trading at Pacira Biosciences, Inc. (PCRX) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2012 | PCRX | 0 | $0 | 285,500 | $3,140,319 | 0 | $0 |
| 2011 | PCRX | 535,714 | $3,749,998 | 97,441 | $1,025,663 | 0 | $0 |
Yearly summary of insider trading at Amarin Corp Plc\uk (AMRN) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2012 | AMRN | 0 | $0 | 1,217,100 | $16,692,148 | 0 | $0 |
| 2011 | AMRN | 0 | $0 | 5,477,900 | $79,885,828 | 0 | $0 |
Yearly summary of insider trading at Supernus Pharmaceuticals, Inc. (SUPN) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2012 | SUPN | 1,100,000 | $5,500,000 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Intercept Pharmaceuticals, Inc. (ICPT) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2015 | ICPT | 0 | $0 | 365,000 | $102,794,531 | 0 | $0 |
| 2014 | ICPT | 0 | $0 | 252,563 | $77,262,304 | 2,303 | $0 |
| 2013 | ICPT | 0 | $0 | 416,673 | $26,042,062 | 1,623 | $0 |
| 2012 | ICPT | 333,334 | $5,000,010 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Otonomy, Inc. (OTIC) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2015 | OTIC | 0 | $0 | 406,304 | $11,639,187 | 0 | $0 |
| 2014 | OTIC | 171,875 | $2,750,000 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Viewray, Inc. (VRAY) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | VRAY | 330,577 | $991,731 | 0 | $0 | 0 | $0 |
| 2016 | VRAY | 1,138,074 | $3,357,318 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Relypsa Inc (RLYP) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2016 | RLYP | 0 | $0 | 4,043,600 | $129,388,328 | 0 | $0 |
| 2015 | RLYP | 500,000 | $6,222,500 | 1,957,551 | $63,454,214 | 0 | $0 |
| 2014 | RLYP | 0 | $0 | 1,084,000 | $28,473,905 | 0 | $0 |
| 2013 | RLYP | 712,192 | $7,834,112 | 0 | $0 | 1,744,711 | $296,600 |
Yearly summary of insider trading at Sientra, Inc. (SIEN) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2015 | SIEN | 0 | $0 | 1,400,306 | $10,826,412 | 0 | $0 |
Yearly summary of insider trading at Corvus Pharmaceuticals, Inc. (CRVS) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2016 | CRVS | 120,899 | $1,539,834 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Roka Bioscience, Inc. (ROKA) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2017 | ROKA | 0 | $0 | 893,470 | $742,148 | 0 | $0 |
| 2014 | ROKA | 383,333 | $4,599,996 | 0 | $0 | 0 | $0 |
Yearly summary of insider trading at Complete Genomics Inc (GNOM) by Isaly Samuel D
| | Insider Buying | Insider Sales | Option Exercises |
|---|
| Year | Symbol | Shares | Value | Shares | Value | Shares | Value |
|---|
| 2012 | GNOM | 0 | $0 | 1,207,936 | $3,305,023 | 0 | $0 |
Insider trading activities at 33 companies by Isaly Samuel D:
1. Cryocor Inc (CRYO)
2. Adaptimmune Therapeutics Plc (ADAP)
3. Steadymed Ltd. (STDY)
4. Aeglea Biotherapeutics, Inc. (AGLE)
5. Audentes Therapeutics, Inc. (BOLD)
6. Selecta Biosciences Inc (SELB)
7. Kala Pharmaceuticals, Inc. (KALA)
8. Loxo Oncology, Inc. (LOXO)
9. Nxstage Medical, Inc. (NXTM)
10. Pieris Pharmaceuticals, Inc. (PIRS)
11. Aerpio Pharmaceuticals, Inc. (NONE)
12. Anthera Pharmaceuticals Inc (ANTH)
13. Aryx Therapeutics, Inc. (ARYX)
14. Glaukos Corp (GKOS)
15. Intellia Therapeutics, Inc. (NTLA)
16. Scpharmaceuticals Inc. (SCPH)
17. Athersys, Inc / New (ATHX)
18. Ambit Biosciences Corp (AMBI)
19. Rhythm Pharmaceuticals, Inc. (RYTM)
20. Mirati Therapeutics, Inc. (MRTX)
21. Dimension Therapeutics, Inc. (DMTX)
22. Albireo Pharma, Inc. (BIOD)
23. Pacira Biosciences, Inc. (PCRX)
24. Amarin Corp Plc\uk (AMRN)
25. Supernus Pharmaceuticals, Inc. (SUPN)
26. Intercept Pharmaceuticals, Inc. (ICPT)
27. Otonomy, Inc. (OTIC)
28. Viewray, Inc. (VRAY)
29. Relypsa Inc (RLYP)
30. Sientra, Inc. (SIEN)
31. Corvus Pharmaceuticals, Inc. (CRVS)
32. Roka Bioscience, Inc. (ROKA)
33. Complete Genomics Inc (GNOM)
Table 1. Insider trading of Cryocor Inc (CRYO) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2005-07-13 | CRYO | Sale | 135,000 | 11.00 | 1,485,000 |
Table 2. Insider trading of Adaptimmune Therapeutics Plc (ADAP) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-03-27 | ADAP | Buy | 1,190,476 | 4.20 | 4,999,999 |
| 2016-05-23 | ADAP | Buy | 1,191,600 | 10.40 | 12,392,640 |
| 2016-05-24 | ADAP | Buy | 518,400 | 10.48 | 5,432,832 |
| 2016-05-20 | ADAP | Buy | 2,400 | 10.04 | 24,095 |
Table 3. Insider trading of Steadymed Ltd. (STDY) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-04-25 | STDY | Buy | 1,174,000 | 5.90 | 6,926,600 |
Table 4. Insider trading of Aeglea Biotherapeutics, Inc. (AGLE) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-02-16 | AGLE | Buy | 30,500 | 5.04 | 153,720 |
| 2017-02-17 | AGLE | Buy | 71,800 | 5.19 | 372,642 |
| 2017-02-21 | AGLE | Buy | 7,000 | 5.36 | 37,520 |
Table 5. Insider trading of Audentes Therapeutics, Inc. (BOLD) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-09-29 | BOLD | Sale | 672,000 | 28.25 | 18,984,000 |
| 2017-09-07 | BOLD | Sale | 5,000 | 22.35 | 111,750 |
Table 6. Insider trading of Selecta Biosciences Inc (SELB) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2016-06-27 | SELB | Buy | 550,000 | 14.00 | 7,700,000 |
| 2016-06-27 | SELB | Buy | 550,000 | 14.00 | 7,700,000 |
Table 7. Insider trading of Kala Pharmaceuticals, Inc. (KALA) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2018-01-10 | KALA | Buy | 170,338 | 12.83 | 2,185,436 |
| 2018-01-11 | KALA | Buy | 41,700 | 13.65 | 569,205 |
| 2018-01-12 | KALA | Buy | 28,446 | 15.40 | 438,068 |
| 2017-07-25 | KALA | Buy | 319,333 | 15.00 | 4,789,995 |
Table 8. Insider trading of Loxo Oncology, Inc. (LOXO) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-12-08 | LOXO | Sale | 250,000 | 82.50 | 20,625,000 |
| 2017-11-22 | LOXO | Sale | 267,000 | 75.00 | 20,025,000 |
| 2017-11-16 | LOXO | Sale | 270,000 | 74.41 | 20,089,620 |
| 2016-08-10 | LOXO | Sale | 447,857 | 26.96 | 12,074,224 |
| 2014-08-06 | LOXO | Buy | 275,385 | 13.00 | 3,580,005 |
Table 9. Insider trading of Nxstage Medical, Inc. (NXTM) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2010-12-09 | NXTM | Sale | 2,356 | 22.60 | 53,255 |
| 2010-09-15 | NXTM | Sale | 54,000 | 16.23 | 876,420 |
| 2010-09-13 | NXTM | Sale | 100,000 | 16.70 | 1,670,000 |
| 2010-09-14 | NXTM | Sale | 96,000 | 16.49 | 1,583,039 |
| 2010-09-10 | NXTM | Sale | 193,900 | 16.52 | 3,203,228 |
| 2010-09-07 | NXTM | Sale | 40,100 | 16.79 | 673,279 |
| 2010-09-08 | NXTM | Sale | 7,000 | 16.50 | 115,500 |
| 2010-09-09 | NXTM | Sale | 8,800 | 16.36 | 143,968 |
| 2010-08-18 | NXTM | Sale | 100,200 | 16.94 | 1,697,388 |
| 2010-08-17 | NXTM | Sale | 288,000 | 17.06 | 4,913,280 |
| 2010-08-16 | NXTM | Sale | 112,000 | 17.11 | 1,916,320 |
| 2010-08-03 | NXTM | Sale | 199,200 | 16.41 | 3,269,469 |
| 2010-08-04 | NXTM | Sale | 101,100 | 16.31 | 1,648,738 |
| 2010-08-02 | NXTM | Sale | 17,400 | 16.39 | 285,099 |
| 2010-07-28 | NXTM | Sale | 128,000 | 16.66 | 2,131,968 |
| 2010-07-27 | NXTM | Sale | 572,556 | 16.93 | 9,691,082 |
| 2008-08-26 | NXTM | Buy | 27,700 | 3.50 | 97,033 |
| 2008-08-25 | NXTM | Buy | 108,900 | 3.37 | 367,101 |
| 2008-08-21 | NXTM | Buy | 26,100 | 3.25 | 84,825 |
| 2008-05-23 | NXTM | Buy | 5,555,556 | 4.50 | 25,000,002 |
Table 10. Insider trading of Pieris Pharmaceuticals, Inc. (PIRS) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2018-01-03 | PIRS | Sale | 1,709,620 | 7.35 | 12,565,707 |
| 2017-12-18 | PIRS | Sale | 147,635 | 5.70 | 841,519 |
| 2017-12-18 | PIRS | Option Ex | 147,635 | 2.32 | 342,660 |
| 2015-07-06 | PIRS | Buy | 500,000 | 2.75 | 1,375,000 |
Table 11. Insider trading of Aerpio Pharmaceuticals, Inc. (NONE) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-03-15 | NONE | Buy | 762,995 | 5.00 | 3,814,975 |
Table 12. Insider trading of Anthera Pharmaceuticals Inc (ANTH) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2013-01-30 | ANTH | Buy | 5,700,000 | .66 | 3,762,000 |
| 2013-01-25 | ANTH | Buy | 1,762,000 | .65 | 1,141,776 |
| 2012-06-29 | ANTH | Sale | 1,283,300 | .73 | 941,942 |
| 2012-03-20 | ANTH | Sale | 116,800 | 2.90 | 338,603 |
| 2012-03-21 | ANTH | Sale | 125,000 | 2.87 | 358,250 |
| 2012-03-22 | ANTH | Sale | 1,306,700 | 2.40 | 3,140,000 |
| 2011-12-09 | ANTH | Sale | 40,000 | 6.75 | 270,000 |
| 2011-12-13 | ANTH | Sale | 16,200 | 6.50 | 105,300 |
| 2011-11-18 | ANTH | Sale | 3,000 | 6.50 | 19,500 |
| 2011-11-17 | ANTH | Sale | 24,000 | 6.67 | 160,080 |
| 2011-11-16 | ANTH | Sale | 25,000 | 6.87 | 171,750 |
| 2011-11-14 | ANTH | Sale | 5,000 | 6.95 | 34,750 |
| 2011-11-15 | ANTH | Sale | 50,000 | 6.93 | 346,500 |
| 2011-11-11 | ANTH | Sale | 5,000 | 7.14 | 35,700 |
| 2011-06-10 | ANTH | Sale | 30,000 | 8.18 | 245,400 |
| 2011-06-09 | ANTH | Sale | 37,000 | 8.11 | 300,070 |
| 2011-06-08 | ANTH | Sale | 33,000 | 8.02 | 264,660 |
| 2011-05-09 | ANTH | Sale | 10,000 | 7.26 | 72,600 |
| 2011-05-10 | ANTH | Sale | 106,400 | 7.23 | 769,272 |
| 2011-05-11 | ANTH | Sale | 13,000 | 7.22 | 93,860 |
| 2011-05-17 | ANTH | Sale | 100,000 | 8.32 | 832,000 |
| 2011-05-18 | ANTH | Sale | 69,334 | 8.03 | 556,752 |
| 2011-05-16 | ANTH | Sale | 12,000 | 7.20 | 86,400 |
| 2011-05-26 | ANTH | Sale | 34,200 | 8.53 | 291,726 |
| 2011-05-25 | ANTH | Sale | 4,800 | 8.65 | 41,520 |
| 2011-05-17 | ANTH | Sale | 100,000 | 8.32 | 832,000 |
| 2011-05-18 | ANTH | Sale | 69,334 | 8.03 | 556,752 |
| 2011-05-16 | ANTH | Sale | 12,000 | 7.20 | 86,400 |
| 2011-05-09 | ANTH | Sale | 10,000 | 7.26 | 72,600 |
| 2011-05-10 | ANTH | Sale | 106,400 | 7.23 | 769,272 |
| 2011-05-11 | ANTH | Sale | 13,000 | 7.22 | 93,860 |
| 2010-09-30 | ANTH | Buy | 19,900 | 4.08 | 81,192 |
Table 13. Insider trading of Aryx Therapeutics, Inc. (ARYX) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2009-05-22 | ARYX | Sale | 2,000,000 | 4.00 | 8,000,000 |
| 2008-11-14 | ARYX | Buy | 1,214,646 | .00 | 0 |
| 2007-11-13 | ARYX | Buy | 300,000 | 10.00 | 3,000,000 |
Table 14. Insider trading of Glaukos Corp (GKOS) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-09-01 | GKOS | Sale | 110,078 | 37.72 | 4,152,142 |
| 2017-08-31 | GKOS | Sale | 44,922 | 37.82 | 1,698,950 |
| 2017-09-05 | GKOS | Sale | 425,200 | 39.45 | 16,772,864 |
| 2017-08-17 | GKOS | Sale | 226,920 | 37.85 | 8,588,922 |
| 2017-08-16 | GKOS | Sale | 65,580 | 38.01 | 2,492,695 |
| 2017-08-15 | GKOS | Sale | 32,500 | 38.29 | 1,244,425 |
| 2017-03-14 | GKOS | Sale | 74,100 | 44.54 | 3,300,414 |
| 2017-03-13 | GKOS | Sale | 211,410 | 45.72 | 9,664,608 |
| 2017-03-10 | GKOS | Sale | 97,028 | 45.98 | 4,461,347 |
| 2017-03-03 | GKOS | Sale | 55,772 | 47.05 | 2,624,072 |
| 2016-08-10 | GKOS | Sale | 117,938 | 33.77 | 3,982,766 |
| 2016-08-12 | GKOS | Sale | 14,100 | 33.72 | 475,452 |
| 2016-08-11 | GKOS | Sale | 160,900 | 33.63 | 5,411,067 |
| 2016-08-03 | GKOS | Sale | 425,000 | 30.59 | 13,000,750 |
| 2015-06-30 | GKOS | Option Ex | 27,607 | .00 | 0 |
Table 15. Insider trading of Intellia Therapeutics, Inc. (NTLA) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2016-05-11 | NTLA | Buy | 250,000 | 18.00 | 4,500,000 |
Table 16. Insider trading of Scpharmaceuticals Inc. (SCPH) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-11-21 | SCPH | Buy | 833,333 | 14.00 | 11,666,662 |
Table 17. Insider trading of Athersys, Inc / New (ATHX) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2011-04-12 | ATHX | Sale | 14,300 | 2.90 | 41,470 |
| 2011-04-11 | ATHX | Sale | 13,000 | 2.91 | 37,830 |
| 2011-04-26 | ATHX | Sale | 7,700 | 2.90 | 22,330 |
| 2011-04-25 | ATHX | Sale | 36,600 | 2.90 | 106,140 |
| 2011-04-21 | ATHX | Sale | 2,000 | 2.90 | 5,800 |
| 2011-04-18 | ATHX | Sale | 15,700 | 2.93 | 46,001 |
| 2011-04-20 | ATHX | Sale | 1,300 | 2.90 | 3,770 |
| 2011-04-15 | ATHX | Sale | 30,200 | 2.90 | 87,580 |
| 2011-04-14 | ATHX | Sale | 20,900 | 2.91 | 60,819 |
| 2011-04-13 | ATHX | Sale | 47,700 | 2.94 | 140,238 |
| 2009-03-16 | ATHX | Buy | 52,200 | .65 | 33,930 |
| 2009-03-17 | ATHX | Buy | 110,000 | .84 | 92,400 |
| 2008-05-22 | ATHX | Buy | 268,000 | 2.40 | 643,200 |
| 2008-05-21 | ATHX | Buy | 130,000 | 2.40 | 312,000 |
| 2008-05-13 | ATHX | Buy | 50,000 | 2.40 | 120,000 |
Table 18. Insider trading of Ambit Biosciences Corp (AMBI) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2013-05-22 | AMBI | Buy | 21,300 | 6.86 | 146,139 |
| 2013-05-23 | AMBI | Buy | 12,500 | 6.99 | 87,362 |
| 2013-05-21 | AMBI | Buy | 669,871 | 7.63 | 5,112,455 |
| 2013-05-20 | AMBI | Buy | 10,600 | 6.78 | 71,836 |
Table 19. Insider trading of Rhythm Pharmaceuticals, Inc. (RYTM) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-10-10 | RYTM | Buy | 355,000 | 17.00 | 6,035,000 |
Table 20. Insider trading of Mirati Therapeutics, Inc. (MRTX) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2015-02-03 | MRTX | Buy | 100,000 | 20.00 | 2,000,000 |
| 2014-06-30 | MRTX | Sale | 14,000 | 20.72 | 290,080 |
| 2014-07-01 | MRTX | Sale | 5,000 | 20.04 | 100,200 |
| 2014-06-27 | MRTX | Sale | 88,332 | 22.44 | 1,982,170 |
| 2013-10-29 | MRTX | Buy | 125,000 | 17.50 | 2,187,500 |
Table 21. Insider trading of Dimension Therapeutics, Inc. (DMTX) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2015-10-27 | DMTX | Buy | 200,000 | 13.00 | 2,600,000 |
Table 22. Insider trading of Albireo Pharma, Inc. (BIOD) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2009-06-10 | BIOD | Sale | 26,988 | 5.24 | 141,417 |
| 2008-02-12 | BIOD | Sale | 154,000 | 14.48 | 2,229,920 |
Table 23. Insider trading of Pacira Biosciences, Inc. (PCRX) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2012-03-09 | PCRX | Sale | 37,000 | 11.25 | 416,102 |
| 2012-03-12 | PCRX | Sale | 63,100 | 11.03 | 696,119 |
| 2012-02-28 | PCRX | Sale | 10,100 | 11.12 | 112,311 |
| 2012-02-27 | PCRX | Sale | 29,000 | 11.05 | 320,363 |
| 2012-02-29 | PCRX | Sale | 3,000 | 10.86 | 32,583 |
| 2012-02-01 | PCRX | Sale | 70,000 | 11.01 | 770,420 |
| 2012-02-02 | PCRX | Sale | 23,300 | 10.86 | 252,921 |
| 2012-02-03 | PCRX | Sale | 50,000 | 10.79 | 539,500 |
| 2011-10-31 | PCRX | Sale | 97,441 | 10.53 | 1,025,663 |
| 2011-02-08 | PCRX | Buy | 535,714 | 7.00 | 3,749,998 |
Table 24. Insider trading of Amarin Corp Plc\uk (AMRN) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2012-09-04 | AMRN | Sale | 233,700 | 14.43 | 3,372,992 |
| 2012-07-27 | AMRN | Sale | 366,300 | 14.61 | 5,350,544 |
| 2012-06-19 | AMRN | Sale | 617,100 | 12.91 | 7,968,612 |
| 2011-04-29 | AMRN | Sale | 100,000 | 16.01 | 1,601,000 |
| 2011-05-02 | AMRN | Sale | 32,900 | 16.30 | 536,270 |
| 2011-04-21 | AMRN | Sale | 750,000 | 16.55 | 12,408,750 |
| 2011-04-18 | AMRN | Sale | 3,000,000 | 15.59 | 46,770,000 |
| 2011-04-20 | AMRN | Sale | 800,000 | 15.79 | 12,632,000 |
| 2011-03-28 | AMRN | Sale | 93,100 | 7.35 | 684,285 |
| 2011-03-25 | AMRN | Sale | 56,900 | 7.47 | 425,043 |
| 2011-03-24 | AMRN | Sale | 23,000 | 7.50 | 172,500 |
| 2011-03-21 | AMRN | Sale | 77,000 | 7.05 | 542,850 |
| 2011-03-14 | AMRN | Sale | 75,000 | 7.33 | 549,750 |
| 2011-03-15 | AMRN | Sale | 50,000 | 7.24 | 362,000 |
| 2011-03-11 | AMRN | Sale | 100,000 | 7.43 | 743,000 |
| 2011-03-07 | AMRN | Sale | 25,000 | 7.68 | 192,000 |
| 2011-03-04 | AMRN | Sale | 43,000 | 7.62 | 327,660 |
| 2011-03-03 | AMRN | Sale | 7,000 | 7.76 | 54,320 |
| 2011-02-28 | AMRN | Sale | 100,000 | 7.73 | 773,000 |
| 2011-03-01 | AMRN | Sale | 50,000 | 7.56 | 378,000 |
| 2011-03-02 | AMRN | Sale | 95,000 | 7.72 | 733,400 |
Table 25. Insider trading of Supernus Pharmaceuticals, Inc. (SUPN) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2012-05-04 | SUPN | Buy | 1,100,000 | 5.00 | 5,500,000 |
Table 26. Insider trading of Intercept Pharmaceuticals, Inc. (ICPT) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2015-03-26 | ICPT | Sale | 157,200 | 287.71 | 45,228,797 |
| 2015-03-25 | ICPT | Sale | 2,800 | 270.23 | 756,644 |
| 2015-03-24 | ICPT | Sale | 45,600 | 271.80 | 12,394,034 |
| 2015-03-23 | ICPT | Sale | 159,400 | 278.64 | 44,415,056 |
| 2014-08-25 | ICPT | Sale | 50,000 | 296.01 | 14,800,500 |
| 2014-08-26 | ICPT | Sale | 61,258 | 300.74 | 18,422,424 |
| 2014-08-14 | ICPT | Sale | 60,000 | 300.36 | 18,021,780 |
| 2014-08-09 | ICPT | Option Ex | 324 | .00 | 0 |
| 2014-05-07 | ICPT | Option Ex | 1,330 | .00 | 0 |
| 2014-05-09 | ICPT | Option Ex | 325 | .00 | 0 |
| 2014-04-09 | ICPT | Sale | 81,305 | 320.00 | 26,017,600 |
| 2014-02-09 | ICPT | Option Ex | 324 | .00 | 0 |
| 2013-11-09 | ICPT | Option Ex | 325 | .00 | 0 |
| 2013-10-21 | ICPT | Sale | 40,088 | 62.50 | 2,505,500 |
| 2013-10-15 | ICPT | Sale | 376,585 | 62.50 | 23,536,562 |
| 2013-08-09 | ICPT | Option Ex | 325 | .00 | 0 |
| 2013-05-09 | ICPT | Option Ex | 324 | .00 | 0 |
| 2013-04-09 | ICPT | Option Ex | 649 | .00 | 0 |
| 2012-10-16 | ICPT | Buy | 333,334 | 15.00 | 5,000,010 |
Table 27. Insider trading of Otonomy, Inc. (OTIC) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2015-11-25 | OTIC | Sale | 34,800 | 28.91 | 1,006,068 |
| 2015-11-27 | OTIC | Sale | 29,000 | 28.97 | 840,130 |
| 2015-11-30 | OTIC | Sale | 3,306 | 28.93 | 95,642 |
| 2015-11-23 | OTIC | Sale | 80,800 | 28.45 | 2,298,760 |
| 2015-11-20 | OTIC | Sale | 83,900 | 28.59 | 2,398,701 |
| 2015-11-24 | OTIC | Sale | 36,100 | 28.75 | 1,037,875 |
| 2015-11-17 | OTIC | Sale | 11,098 | 28.95 | 321,231 |
| 2015-11-19 | OTIC | Sale | 127,300 | 28.60 | 3,640,780 |
| 2014-08-18 | OTIC | Buy | 171,875 | 16.00 | 2,750,000 |
Table 28. Insider trading of Viewray, Inc. (VRAY) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-01-18 | VRAY | Buy | 330,577 | 3.00 | 991,731 |
| 2016-08-22 | VRAY | Buy | 1,138,074 | 2.95 | 3,357,318 |
Table 29. Insider trading of Relypsa Inc (RLYP) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2016-07-22 | RLYP | Sale | 3,700,000 | 32.00 | 118,400,000 |
| 2016-07-25 | RLYP | Sale | 343,600 | 31.98 | 10,988,328 |
| 2015-12-23 | RLYP | Sale | 100,000 | 27.16 | 2,716,000 |
| 2015-12-22 | RLYP | Sale | 150,000 | 26.70 | 4,005,749 |
| 2015-12-21 | RLYP | Sale | 250,000 | 27.95 | 6,986,250 |
| 2015-10-22 | RLYP | Buy | 500,000 | 12.45 | 6,222,500 |
| 2015-05-18 | RLYP | Sale | 1,457,551 | 34.13 | 49,746,215 |
| 2014-09-17 | RLYP | Sale | 49,000 | 25.07 | 1,228,430 |
| 2014-09-16 | RLYP | Sale | 45,000 | 25.75 | 1,158,975 |
| 2014-08-15 | RLYP | Sale | 990,000 | 26.35 | 26,086,500 |
| 2013-11-20 | RLYP | Buy | 712,192 | 11.00 | 7,834,112 |
| 2013-11-20 | RLYP | Option Ex | 1,744,711 | .17 | 296,600 |
Table 30. Insider trading of Sientra, Inc. (SIEN) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2015-10-12 | SIEN | Sale | 287,891 | 5.98 | 1,721,588 |
| 2015-10-09 | SIEN | Sale | 212,709 | 7.03 | 1,495,344 |
| 2015-10-08 | SIEN | Sale | 400,000 | 7.24 | 2,896,000 |
| 2015-10-07 | SIEN | Sale | 53,900 | 7.36 | 396,704 |
| 2015-10-05 | SIEN | Sale | 138,100 | 8.19 | 1,131,039 |
| 2015-10-06 | SIEN | Sale | 7,000 | 7.80 | 54,600 |
| 2015-10-02 | SIEN | Sale | 47,900 | 10.34 | 495,286 |
| 2015-09-29 | SIEN | Sale | 10,558 | 10.08 | 106,424 |
| 2015-09-30 | SIEN | Sale | 43,840 | 10.17 | 445,852 |
| 2015-10-01 | SIEN | Sale | 47,500 | 10.34 | 491,150 |
| 2015-09-25 | SIEN | Sale | 132,000 | 10.57 | 1,395,240 |
| 2015-09-24 | SIEN | Sale | 8,306 | 10.59 | 87,985 |
| 2015-09-28 | SIEN | Sale | 10,602 | 10.30 | 109,200 |
Table 31. Insider trading of Corvus Pharmaceuticals, Inc. (CRVS) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2016-06-23 | CRVS | Buy | 100 | 12.92 | 1,292 |
| 2016-06-24 | CRVS | Buy | 900 | 12.99 | 11,691 |
| 2016-06-21 | CRVS | Buy | 26,083 | 12.87 | 335,688 |
| 2016-06-17 | CRVS | Buy | 12,300 | 12.48 | 153,504 |
| 2016-06-14 | CRVS | Buy | 10,000 | 12.71 | 127,100 |
| 2016-06-15 | CRVS | Buy | 5,000 | 11.94 | 59,700 |
| 2016-06-16 | CRVS | Buy | 5,000 | 12.04 | 60,199 |
| 2016-06-09 | CRVS | Buy | 30,000 | 12.95 | 388,500 |
| 2016-06-10 | CRVS | Buy | 20,000 | 12.98 | 259,600 |
| 2016-05-20 | CRVS | Buy | 4,716 | 13.09 | 61,732 |
| 2016-05-18 | CRVS | Buy | 4,200 | 11.55 | 48,510 |
| 2016-05-19 | CRVS | Buy | 2,600 | 12.43 | 32,318 |
Table 32. Insider trading of Roka Bioscience, Inc. (ROKA) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2017-10-03 | ROKA | Sale | 201,617 | .68 | 137,099 |
| 2017-09-28 | ROKA | Sale | 380,542 | .72 | 273,990 |
| 2017-09-29 | ROKA | Sale | 94,134 | .74 | 69,659 |
| 2017-09-26 | ROKA | Sale | 74,802 | 1.03 | 77,046 |
| 2017-09-27 | ROKA | Sale | 52,799 | .92 | 48,575 |
| 2017-08-24 | ROKA | Sale | 13,200 | 1.50 | 19,800 |
| 2017-08-23 | ROKA | Sale | 1,100 | 1.50 | 1,650 |
| 2017-08-18 | ROKA | Sale | 66,796 | 1.52 | 101,529 |
| 2017-08-21 | ROKA | Sale | 2,980 | 1.49 | 4,440 |
| 2017-08-22 | ROKA | Sale | 5,500 | 1.52 | 8,360 |
| 2014-07-22 | ROKA | Buy | 383,333 | 12.00 | 4,599,996 |
Table 33. Insider trading of Complete Genomics Inc (GNOM) by Isaly Samuel D
| Trade Date | Symbol | Trade Type | Shares | Price ($) | Value ($) |
|---|
| 2012-07-13 | GNOM | Sale | 479,300 | 2.51 | 1,203,522 |
| 2012-07-11 | GNOM | Sale | 507,936 | 2.90 | 1,472,506 |
| 2012-07-12 | GNOM | Sale | 220,700 | 2.85 | 628,995 |
Insider trading activities including stock purchases, stock sales, and option exercises
listed in the above table cannot be completely guaranteed as to their accuracy.
For more information regarding the trades made by Isaly Samuel D
(Director of Kala Pharmaceuticals, Inc. at the time of this reporting) see
the Securities and Exchange Commission (SEC) website.