Insider Trading History of Makower Joshua

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) of Makower Joshua since 2016. This trader's CIK number is 1235952. At the time of last reporting, Makower Joshua was the 10% Owner of Marker Therapeutics, Inc.. (stock ticker symbol MRKR). Also see all insider trading activities at Marker Therapeutics, Inc..

Note that in the past MAKOWER JOSHUA also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Akouos, Inc. (AKUS) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	AKUS	588,235	$9,999,995	0	$0	0	$0

Yearly summary of insider trading at Aveo Pharmaceuticals, Inc. (AVEO) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	AVEO	1,428,571	$7,499,997	0	$0	0	$0
2019	AVEO	4,347,827	$4,956,522	0	$0	0	$0
2018	AVEO	4,296,865	$8,662,202	0	$0	0	$0
2017	AVEO	6,000,000	$3,000,000	0	$0	0	$0

Yearly summary of insider trading at Achaogen, Inc. (AKAO) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	AKAO	500,000	$6,750,000	0	$0	0	$0

Yearly summary of insider trading at Inozyme Pharma, Inc. (INZY) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	INZY	250,000	$4,000,000	0	$0	0	$0

Yearly summary of insider trading at Genocea Biosciences, Inc. (GNCA) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	GNCA	3,151,260	$7,090,335	0	$0	0	$0
2019	GNCA	12,805,411	$14,685,631	0	$0	0	$0

Yearly summary of insider trading at Regulus Therapeutics Inc. (RGLS) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	RGLS	4,398,602	$2,735,930	0	$0	0	$0
2019	RGLS	1,136,704	$1,227,640	0	$0	0	$0

Yearly summary of insider trading at Marker Therapeutics, Inc. (MRKR) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	MRKR	5,714,285	$9,999,998	0	$0	0	$0

Yearly summary of insider trading at Metacrine, Inc. (MTCR) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	MTCR	769,230	$9,999,990	0	$0	0	$0

Yearly summary of insider trading at Nkarta, Inc. (NKTK) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	NKTK	666,666	$11,999,988	0	$0	0	$0

Yearly summary of insider trading at Arca Biopharma, Inc. (ABIO) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	ABIO	0	$0	1,460,209	$731,564	0	$0

Yearly summary of insider trading at Ardelyx, Inc. (ARDX) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	ARDX	2,527,301	$23,333,337	0	$0	0	$0

Yearly summary of insider trading at Trevi Therapeutics, Inc. (TRVI) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	TRVI	0	$0	564	$1,500	0	$0
2019	TRVI	2,500,000	$25,000,000	0	$0	0	$0

Yearly summary of insider trading at Eargo, Inc. (EAR) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	EAR	311,111	$5,599,998	0	$0	0	$0

Yearly summary of insider trading at Mirum Pharmaceuticals, Inc. (MIRM) by Makower Joshua

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	MIRM	450,000	$6,750,000	0	$0	0	$0

Insider trading activities at 14 companies by Makower Joshua:

1. Akouos, Inc. (AKUS)

2. Aveo Pharmaceuticals, Inc. (AVEO)

3. Achaogen, Inc. (AKAO)

4. Inozyme Pharma, Inc. (INZY)

5. Genocea Biosciences, Inc. (GNCA)

6. Regulus Therapeutics Inc. (RGLS)

7. Marker Therapeutics, Inc. (MRKR)

8. Metacrine, Inc. (MTCR)

9. Nkarta, Inc. (NKTK)

10. Arca Biopharma, Inc. (ABIO)

11. Ardelyx, Inc. (ARDX)

12. Trevi Therapeutics, Inc. (TRVI)

13. Eargo, Inc. (EAR)

14. Mirum Pharmaceuticals, Inc. (MIRM)

Table 1. Insider trading of Akouos, Inc. (AKUS) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-06-30	AKUS	Buy	588,235	17.00	9,999,995

Table 2. Insider trading of Aveo Pharmaceuticals, Inc. (AVEO) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-06-19	AVEO	Buy	1,428,571	5.25	7,499,997
2019-04-08	AVEO	Buy	4,347,827	1.14	4,956,522
2018-12-21	AVEO	Buy	300,000	1.50	448,500
2018-12-20	AVEO	Buy	200,000	1.63	326,000
2018-12-11	AVEO	Buy	61,200	1.98	121,114
2018-12-07	AVEO	Buy	117,100	1.98	232,326
2018-12-10	AVEO	Buy	26,000	1.98	51,584
2018-12-06	AVEO	Buy	27,300	1.99	54,408
2018-11-28	AVEO	Buy	24,500	1.99	48,828
2018-11-30	AVEO	Buy	71,900	1.98	142,074
2018-11-20	AVEO	Buy	170,000	1.98	336,090
2018-11-19	AVEO	Buy	510,000	1.88	956,760
2018-11-16	AVEO	Buy	350,000	1.85	649,250
2018-11-15	AVEO	Buy	340,000	1.86	632,060
2018-08-21	AVEO	Buy	663,716	2.26	1,499,998
2018-07-18	AVEO	Buy	200,000	1.95	390,600
2018-07-19	AVEO	Buy	50,600	2.00	101,149
2018-06-28	AVEO	Buy	187,130	2.10	392,785
2018-06-27	AVEO	Buy	5,295	2.15	11,384
2018-05-30	AVEO	Buy	275	2.15	591
2018-05-08	AVEO	Buy	70,873	2.13	151,242
2018-04-10	AVEO	Buy	203,200	2.46	500,075
2018-04-09	AVEO	Buy	32,100	2.43	78,099
2018-04-06	AVEO	Buy	685,676	2.24	1,537,285
2017-03-28	AVEO	Buy	6,000,000	.50	3,000,000

Table 3. Insider trading of Achaogen, Inc. (AKAO) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-12-19	AKAO	Buy	500,000	13.50	6,750,000

Table 4. Insider trading of Inozyme Pharma, Inc. (INZY) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-07-28	INZY	Buy	250,000	16.00	4,000,000

Table 5. Insider trading of Genocea Biosciences, Inc. (GNCA) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-07-24	GNCA	Buy	3,151,260	2.25	7,090,335
2019-06-24	GNCA	Buy	2,857,142	3.50	9,999,997
2019-02-14	GNCA	Buy	9,948,269	.47	4,685,634

Table 6. Insider trading of Regulus Therapeutics Inc. (RGLS) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-12-04	RGLS	Buy	4,398,602	.62	2,735,930
2019-05-07	RGLS	Buy	1,136,704	1.08	1,227,640

Table 7. Insider trading of Marker Therapeutics, Inc. (MRKR) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-03-16	MRKR	Buy	5,714,285	1.75	9,999,998

Table 8. Insider trading of Metacrine, Inc. (MTCR) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-09-18	MTCR	Buy	769,230	13.00	9,999,990

Table 9. Insider trading of Nkarta, Inc. (NKTK) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-07-14	NKTK	Buy	666,666	18.00	11,999,988

Table 10. Insider trading of Arca Biopharma, Inc. (ABIO) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-02-26	ABIO	Sale	1,460,209	.50	731,564

Table 11. Insider trading of Ardelyx, Inc. (ARDX) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-07-18	ARDX	Buy	1,527,301	8.73	13,333,337
2016-01-13	ARDX	Buy	1,000,000	10.00	10,000,000

Table 12. Insider trading of Trevi Therapeutics, Inc. (TRVI) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-04-03	TRVI	Sale	564	2.66	1,500
2019-05-09	TRVI	Buy	2,500,000	10.00	25,000,000

Table 13. Insider trading of Eargo, Inc. (EAR) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-10-20	EAR	Buy	311,111	18.00	5,599,998

Table 14. Insider trading of Mirum Pharmaceuticals, Inc. (MIRM) by Makower Joshua

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-07-22	MIRM	Buy	450,000	15.00	6,750,000

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Makower Joshua (10% Owner of Marker Therapeutics, Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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