Insider Trading History of Orbimed Capital Gp Vi Llc

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) of Orbimed Capital Gp Vi Llc since 2018. This trader's CIK number is 1682115. At the time of last reporting, Orbimed Capital Gp Vi Llc was the Officer of Neuropace Inc. (stock ticker symbol NPCE). Also see all insider trading activities at Neuropace Inc.

Note that in the past OrbiMed Capital GP VI LLC also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Constellation Pharmaceuticals Inc (CNST) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	CNST	200,000	$3,000,000	0	$0	0	$0

Yearly summary of insider trading at Kala Bio, Inc. (KALA) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	KALA	755,125	$11,232,299	0	$0	0	$0

Yearly summary of insider trading at Calcimedica, Inc. (GRAY) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	GRAY	562,500	$9,000,000	0	$0	0	$0

Yearly summary of insider trading at Adicet Bio, Inc. (TORC) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	TORC	533,333	$7,999,995	0	$0	0	$0

Yearly summary of insider trading at Oric Pharmaceuticals, Inc. (ORIC) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	ORIC	0	$0	553,146	$15,171,999	0	$0
2020	ORIC	281,250	$4,500,000	0	$0	0	$0

Yearly summary of insider trading at Turnstone Biologics Corp. (TSBX) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	TSBX	416,666	$4,999,992	0	$0	0	$0

Yearly summary of insider trading at Turning Point Therapeutics, Inc. (TPTX) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	TPTX	360,000	$6,480,000	0	$0	0	$0

Yearly summary of insider trading at Verona Pharma Plc (VRNA) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	VRNA	0	$0	482,913	$10,262,426	0	$0
2022	VRNA	0	$0	6,139,864	$137,251,315	0	$0

Yearly summary of insider trading at Prevail Therapeutics Inc. (PRVL) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	PRVL	882,352	$14,999,984	0	$0	0	$0

Yearly summary of insider trading at Neuropace Inc (NPCE) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	NPCE	0	$0	168,136	$2,670,840	0	$0
2024	NPCE	0	$0	597,632	$8,611,783	0	$0
2023	NPCE	0	$0	8,314	$75,449	0	$0
2021	NPCE	235,000	$3,995,000	0	$0	0	$0

Yearly summary of insider trading at Springworks Therapeutics, Inc. (SWTX) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	SWTX	0	$0	274,568	$10,464,362	0	$0
2021	SWTX	0	$0	1,371,498	$114,400,117	0	$0
2019	SWTX	275,000	$4,950,000	0	$0	0	$0

Yearly summary of insider trading at Alpine Immune Sciences, Inc. (ALPN) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	ALPN	0	$0	600,000	$8,550,000	0	$0
2019	ALPN	372,439	$1,999,997	0	$0	0	$0

Yearly summary of insider trading at Cti Biopharma Corp (CTIC) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	CTIC	0	$0	2,000,000	$7,000,000	0	$0

Yearly summary of insider trading at Nextcure, Inc. (NXTC) by Orbimed Capital Gp Vi Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	NXTC	350,000	$5,250,000	0	$0	0	$0

Insider trading activities at 14 companies by Orbimed Capital Gp Vi Llc:

1. Constellation Pharmaceuticals Inc (CNST)

2. Kala Bio, Inc. (KALA)

3. Calcimedica, Inc. (GRAY)

4. Adicet Bio, Inc. (TORC)

5. Oric Pharmaceuticals, Inc. (ORIC)

6. Turnstone Biologics Corp. (TSBX)

7. Turning Point Therapeutics, Inc. (TPTX)

8. Verona Pharma Plc (VRNA)

9. Prevail Therapeutics Inc. (PRVL)

10. Neuropace Inc (NPCE)

11. Springworks Therapeutics, Inc. (SWTX)

12. Alpine Immune Sciences, Inc. (ALPN)

13. Cti Biopharma Corp (CTIC)

14. Nextcure, Inc. (NXTC)

Table 1. Insider trading of Constellation Pharmaceuticals Inc (CNST) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-07-23	CNST	Buy	200,000	15.00	3,000,000

Table 2. Insider trading of Kala Bio, Inc. (KALA) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-02-08	KALA	Buy	25,000	12.93	323,250
2018-02-02	KALA	Buy	37,840	14.73	557,383
2018-02-01	KALA	Buy	22,840	14.99	342,371
2018-01-31	KALA	Buy	339,400	15.00	5,091,000
2018-01-26	KALA	Buy	22,760	14.93	339,806
2018-01-29	KALA	Buy	50,000	14.99	749,500
2018-01-19	KALA	Buy	74,931	14.95	1,120,218
2018-01-22	KALA	Buy	75,000	14.98	1,123,500
2018-01-23	KALA	Buy	4,363	14.99	65,401
2018-01-12	KALA	Buy	38,354	14.50	556,133
2018-01-24	KALA	Buy	64,637	14.91	963,737

Table 3. Insider trading of Calcimedica, Inc. (GRAY) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-09-25	GRAY	Buy	562,500	16.00	9,000,000

Table 4. Insider trading of Adicet Bio, Inc. (TORC) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-01-30	TORC	Buy	533,333	15.00	7,999,995

Table 5. Insider trading of Oric Pharmaceuticals, Inc. (ORIC) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-03-29	ORIC	Sale	75,555	23.31	1,761,187
2021-03-30	ORIC	Sale	27,869	23.93	666,905
2021-03-24	ORIC	Sale	32,959	24.80	817,383
2021-03-25	ORIC	Sale	51,523	24.70	1,272,618
2021-03-26	ORIC	Sale	27,816	23.88	664,246
2021-03-19	ORIC	Sale	21,275	26.47	563,149
2021-03-22	ORIC	Sale	7,673	26.47	203,104
2021-03-23	ORIC	Sale	3,992	24.32	97,085
2021-03-16	ORIC	Sale	41,353	27.72	1,146,305
2021-03-17	ORIC	Sale	18,790	28.43	534,199
2021-03-18	ORIC	Sale	6,059	28.03	169,833
2021-03-11	ORIC	Sale	58,551	33.04	1,934,525
2021-03-15	ORIC	Sale	89,210	29.14	2,599,579
2021-03-12	ORIC	Sale	90,521	30.29	2,741,881
2020-04-24	ORIC	Buy	281,250	16.00	4,500,000

Table 6. Insider trading of Turnstone Biologics Corp. (TSBX) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-07-20	TSBX	Buy	416,666	12.00	4,999,992

Table 7. Insider trading of Turning Point Therapeutics, Inc. (TPTX) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-04-22	TPTX	Buy	360,000	18.00	6,480,000

Table 8. Insider trading of Verona Pharma Plc (VRNA) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-05-11	VRNA	Sale	80,000	22.26	1,780,800
2023-05-15	VRNA	Sale	359,713	20.98	7,546,778
2023-05-12	VRNA	Sale	43,200	21.64	934,848
2022-12-22	VRNA	Sale	3,969,496	21.89	86,892,267
2022-12-23	VRNA	Sale	2,170,368	23.20	50,359,048

Table 9. Insider trading of Prevail Therapeutics Inc. (PRVL) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-06-24	PRVL	Buy	882,352	17.00	14,999,984

Table 10. Insider trading of Neuropace Inc (NPCE) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-05-14	NPCE	Sale	168,136	15.88	2,670,840
2024-05-02	NPCE	Sale	8,842	14.01	123,876
2024-05-03	NPCE	Sale	4,674	14.03	65,576
2024-05-01	NPCE	Sale	15,690	14.02	219,973
2024-04-24	NPCE	Sale	1,781	14.06	25,040
2024-04-23	NPCE	Sale	21,791	14.29	311,393
2024-04-22	NPCE	Sale	24,609	14.05	345,756
2024-04-19	NPCE	Sale	18,253	14.02	255,907
2024-04-16	NPCE	Sale	14,069	14.01	197,106
2024-04-18	NPCE	Sale	2,623	14.06	36,879
2024-04-17	NPCE	Sale	300	14.15	4,245
2024-04-11	NPCE	Sale	461,899	14.49	6,692,916
2024-04-12	NPCE	Sale	23,101	14.42	333,116
2023-10-02	NPCE	Sale	7,614	9.08	69,135
2023-10-03	NPCE	Sale	700	9.02	6,314
2021-04-21	NPCE	Buy	235,000	17.00	3,995,000

Table 11. Insider trading of Springworks Therapeutics, Inc. (SWTX) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-08-09	SWTX	Sale	69,568	37.47	2,606,712
2022-08-08	SWTX	Sale	205,000	38.33	7,857,650
2021-07-01	SWTX	Sale	15,959	85.01	1,356,674
2021-06-25	SWTX	Sale	22,334	85.14	1,901,516
2021-06-24	SWTX	Sale	34,200	85.22	2,914,524
2021-06-23	SWTX	Sale	100	85.00	8,500
2021-06-10	SWTX	Sale	30,852	85.09	2,625,196
2021-06-07	SWTX	Sale	371	84.90	31,497
2021-06-08	SWTX	Sale	42,633	85.37	3,639,579
2021-06-09	SWTX	Sale	5,049	85.33	430,831
2021-03-01	SWTX	Sale	1,220,000	83.19	101,491,800
2019-09-17	SWTX	Buy	275,000	18.00	4,950,000

Table 12. Insider trading of Alpine Immune Sciences, Inc. (ALPN) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-12-28	ALPN	Sale	600,000	14.25	8,550,000
2019-01-18	ALPN	Buy	372,439	5.37	1,999,997

Table 13. Insider trading of Cti Biopharma Corp (CTIC) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-01-07	CTIC	Sale	2,000,000	3.50	7,000,000

Table 14. Insider trading of Nextcure, Inc. (NXTC) by Orbimed Capital Gp Vi Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-05-13	NXTC	Buy	350,000	15.00	5,250,000

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Orbimed Capital Gp Vi Llc (Officer of Neuropace Inc at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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