Insider Trading History of Orbimed Genesis Gp Llc

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) of Orbimed Genesis Gp Llc since 2020. This trader's CIK number is 1808744. At the time of last reporting, Orbimed Genesis Gp Llc was the Officer of Shattuck Labs, Inc.. (stock ticker symbol STTK). Also see all insider trading activities at Shattuck Labs, Inc..

Note that in the past OrbiMed Genesis GP LLC also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Disc Medicine, Inc. (IRON) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	IRON	0	$0	370,551	$20,204,839	0	$0
2024	IRON	83,334	$3,000,024	0	$0	0	$0
2023	IRON	108,696	$2,500,008	569,124	$32,588,495	1,724	$65,512

Yearly summary of insider trading at Mbx Biosciences, Inc. (MBX) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	MBX	190,672	$2,021,044	0	$0	0	$0
2024	MBX	750,000	$12,000,000	0	$0	0	$0

Yearly summary of insider trading at Janux Therapeutics, Inc. (JANX) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	JANX	705,853	$11,999,501	553,100	$10,588,951	0	$0

Yearly summary of insider trading at Terns Pharmaceuticals, Inc. (TERN) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	TERN	0	$0	56,164	$561,640	0	$0
2022	TERN	3,965,862	$10,929,798	0	$0	0	$0

Yearly summary of insider trading at Theseus Pharmaceuticals, Inc. (THRX) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	THRX	203,134	$2,019,187	0	$0	0	$0
2021	THRX	625,000	$10,000,000	0	$0	0	$0

Yearly summary of insider trading at Imagenebio, Inc. (IKNA) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	IKNA	252,225	$1,112,985	0	$0	0	$0
2021	IKNA	423,400	$6,774,400	0	$0	0	$0

Yearly summary of insider trading at Enliven Therapeutics, Inc. (ELVN) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	ELVN	0	$0	1,033,300	$22,877,262	0	$0
2023	ELVN	0	$0	0	$0	2,125	$9,095

Yearly summary of insider trading at Galecto, Inc. (GLTO) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	GLTO	733,333	$10,999,995	0	$0	0	$0

Yearly summary of insider trading at Edgewise Therapeutics, Inc. (EWTX) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	EWTX	496,771	$10,000,000	0	$0	0	$0
2024	EWTX	454,545	$4,999,995	0	$0	0	$0
2022	EWTX	138,000	$994,980	0	$0	0	$0
2021	EWTX	359,375	$5,750,000	0	$0	0	$0

Yearly summary of insider trading at Shattuck Labs, Inc. (STTK) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	STTK	6,306,127	$5,473,718	0	$0	0	$0

Yearly summary of insider trading at Compass Therapeutics, Inc. (CMPX) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	CMPX	0	$0	3,571,428	$5,678,570	0	$0
2022	CMPX	719,875	$1,908,151	0	$0	0	$0
2021	CMPX	5,357,143	$18,750,000	0	$0	0	$0

Yearly summary of insider trading at Keros Therapeutics, Inc. (KROS) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	KROS	0	$0	250,000	$11,002,500	0	$0
2020	KROS	375,200	$6,003,200	0	$0	0	$0

Yearly summary of insider trading at Alpine Immune Sciences, Inc. (ALPN) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	ALPN	0	$0	1,546,347	$29,650,370	0	$0
2021	ALPN	1,010,637	$9,499,987	0	$0	0	$0

Yearly summary of insider trading at Scpharmaceuticals Inc. (SCPH) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	SCPH	500,000	$2,000,000	0	$0	0	$0
2022	SCPH	762,380	$4,002,495	0	$0	0	$0
2020	SCPH	1,387,283	$11,999,997	0	$0	0	$0

Yearly summary of insider trading at Logicbio Therapeutics, Inc. (LOGC) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	LOGC	1,481,482	$8,888,892	0	$0	0	$0

Yearly summary of insider trading at Pmv Pharmaceuticals, Inc. (PMVP) by Orbimed Genesis Gp Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	PMVP	0	$0	87,786	$195,762	0	$0
2022	PMVP	0	$0	26,253	$418,210	0	$0

Insider trading activities at 16 companies by Orbimed Genesis Gp Llc:

1. Disc Medicine, Inc. (IRON)

2. Mbx Biosciences, Inc. (MBX)

3. Janux Therapeutics, Inc. (JANX)

4. Terns Pharmaceuticals, Inc. (TERN)

5. Theseus Pharmaceuticals, Inc. (THRX)

6. Imagenebio, Inc. (IKNA)

7. Enliven Therapeutics, Inc. (ELVN)

8. Galecto, Inc. (GLTO)

9. Edgewise Therapeutics, Inc. (EWTX)

10. Shattuck Labs, Inc. (STTK)

11. Compass Therapeutics, Inc. (CMPX)

12. Keros Therapeutics, Inc. (KROS)

13. Alpine Immune Sciences, Inc. (ALPN)

14. Scpharmaceuticals Inc. (SCPH)

15. Logicbio Therapeutics, Inc. (LOGC)

16. Pmv Pharmaceuticals, Inc. (PMVP)

Table 1. Insider trading of Disc Medicine, Inc. (IRON) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-03-24	IRON	Sale	5,738	54.11	310,483
2025-03-19	IRON	Sale	39,656	54.02	2,142,217
2025-03-20	IRON	Sale	2,762	54.01	149,175
2025-03-21	IRON	Sale	10,011	54.00	540,594
2025-03-10	IRON	Sale	202,146	54.65	11,047,278
2025-03-12	IRON	Sale	83,182	54.74	4,553,798
2025-03-11	IRON	Sale	27,056	54.01	1,461,294
2024-06-17	IRON	Buy	83,334	36.00	3,000,024
2023-12-18	IRON	Option Ex	1,724	38.00	65,512
2023-12-18	IRON	Sale	1,724	59.24	102,129
2023-12-14	IRON	Sale	433,200	56.75	24,584,100
2023-12-13	IRON	Sale	106,700	58.56	6,248,352
2023-12-12	IRON	Sale	27,300	60.16	1,642,368
2023-12-14	IRON	Sale	200	57.73	11,546
2023-02-15	IRON	Buy	108,696	23.00	2,500,008

Table 2. Insider trading of Mbx Biosciences, Inc. (MBX) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-02-18	MBX	Buy	143,170	10.84	1,551,962
2025-02-14	MBX	Buy	47,502	9.88	469,082
2024-09-16	MBX	Buy	750,000	16.00	12,000,000

Table 3. Insider trading of Janux Therapeutics, Inc. (JANX) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-12-29	JANX	Sale	40,400	20.30	820,120
2021-12-21	JANX	Sale	119,400	19.00	2,268,600
2021-12-16	JANX	Sale	393,300	19.07	7,500,231
2021-06-15	JANX	Buy	705,853	17.00	11,999,501

Table 4. Insider trading of Terns Pharmaceuticals, Inc. (TERN) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-07-16	TERN	Sale	5,188	10.00	51,880
2024-07-15	TERN	Sale	50,976	10.00	509,760
2022-12-23	TERN	Buy	137,931	7.25	999,999
2022-12-23	TERN	Buy	137,931	7.25	999,999
2022-08-16	TERN	Buy	3,690,000	2.42	8,929,800

Table 5. Insider trading of Theseus Pharmaceuticals, Inc. (THRX) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-01-20	THRX	Buy	35,000	9.95	348,250
2022-01-19	THRX	Buy	11,521	9.97	114,864
2022-01-21	THRX	Buy	111,896	9.97	1,115,603
2022-01-11	THRX	Buy	8,500	10.24	87,040
2022-01-12	THRX	Buy	18,897	10.06	190,103
2022-01-13	THRX	Buy	17,320	9.43	163,327
2021-10-12	THRX	Buy	625,000	16.00	10,000,000

Table 6. Insider trading of Imagenebio, Inc. (IKNA) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-06-22	IKNA	Buy	66,806	3.55	237,161
2022-06-23	IKNA	Buy	23,419	3.71	86,884
2022-06-24	IKNA	Buy	162,000	4.87	788,940
2021-03-30	IKNA	Buy	423,400	16.00	6,774,400

Table 7. Insider trading of Enliven Therapeutics, Inc. (ELVN) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-05-16	ELVN	Sale	1,033,300	22.14	22,877,262
2023-05-17	ELVN	Option Ex	2,125	4.28	9,095

Table 8. Insider trading of Galecto, Inc. (GLTO) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-11-02	GLTO	Buy	733,333	15.00	10,999,995

Table 9. Insider trading of Edgewise Therapeutics, Inc. (EWTX) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-04-03	EWTX	Buy	496,771	20.13	10,000,000
2024-01-23	EWTX	Buy	454,545	11.00	4,999,995
2022-05-18	EWTX	Buy	138,000	7.21	994,980
2021-03-30	EWTX	Buy	359,375	16.00	5,750,000

Table 10. Insider trading of Shattuck Labs, Inc. (STTK) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-08-25	STTK	Buy	6,306,127	.87	5,473,718

Table 11. Insider trading of Compass Therapeutics, Inc. (CMPX) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-04-09	CMPX	Sale	3,571,428	1.59	5,678,570
2022-11-08	CMPX	Buy	402,000	3.21	1,290,420
2022-05-13	CMPX	Buy	30,722	2.49	76,497
2022-05-12	CMPX	Buy	97,094	2.35	228,170
2022-05-11	CMPX	Buy	64,700	1.79	115,813
2022-05-09	CMPX	Buy	90,712	1.56	141,510
2022-05-10	CMPX	Buy	24,447	1.60	39,115
2022-05-06	CMPX	Buy	10,200	1.63	16,626
2021-11-04	CMPX	Buy	5,357,143	3.50	18,750,000

Table 12. Insider trading of Keros Therapeutics, Inc. (KROS) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-08-13	KROS	Sale	250,000	44.01	11,002,500
2020-04-13	KROS	Buy	375,200	16.00	6,003,200

Table 13. Insider trading of Alpine Immune Sciences, Inc. (ALPN) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-12-28	ALPN	Sale	1,364,849	19.07	26,027,670
2023-12-27	ALPN	Sale	181,498	19.96	3,622,700
2021-09-17	ALPN	Buy	1,010,637	9.40	9,499,987

Table 14. Insider trading of Scpharmaceuticals Inc. (SCPH) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-08-13	SCPH	Buy	500,000	4.00	2,000,000
2022-11-25	SCPH	Buy	762,380	5.25	4,002,495
2020-05-21	SCPH	Buy	1,387,283	8.65	11,999,997

Table 15. Insider trading of Logicbio Therapeutics, Inc. (LOGC) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-10-01	LOGC	Buy	1,481,482	6.00	8,888,892

Table 16. Insider trading of Pmv Pharmaceuticals, Inc. (PMVP) by Orbimed Genesis Gp Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-11-22	PMVP	Sale	87,786	2.23	195,762
2022-05-26	PMVP	Sale	26,253	15.93	418,210

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Orbimed Genesis Gp Llc (Officer of Shattuck Labs, Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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