Insider Trading History of Fmr Llc

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) of Fmr Llc since 2015. This trader's CIK number is 315066. At the time of last reporting, Fmr Llc was the Officer of Metsera, Inc.. (stock ticker symbol MTSR). Also see all insider trading activities at Metsera, Inc..

Note that in the past FMR LLC also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Coherus Biosciences, Inc. (CHRS) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	CHRS	0	$0	148,600	$4,367,816	0	$0

Yearly summary of insider trading at Regenxbio Inc. (RGNX) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	RGNX	0	$0	206,752	$2,332,519	0	$0

Yearly summary of insider trading at Fidelity Private Credit Fund (NONE) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	NONE	347,504	$8,767,768	0	$0	0	$0

Yearly summary of insider trading at Cogent Biosciences, Inc. (UMRX) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	UMRX	94,052	$1,128,624	0	$0	0	$0

Yearly summary of insider trading at Kineta, Inc./de (PTI) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2017	PTI	0	$0	257,300	$3,467,627	0	$0
2016	PTI	375,000	$3,000,000	0	$0	0	$0

Yearly summary of insider trading at Precision Biosciences Inc (DTIL) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	DTIL	50,000	$800,000	0	$0	0	$0

Yearly summary of insider trading at Blueprint Medicines Corp (BPMC) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2015	BPMC	125,000	$2,250,000	931,650	$19,079,255	0	$0

Yearly summary of insider trading at Viewray, Inc. (VRAY) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	VRAY	0	$0	1,390,225	$15,828,881	0	$0
2017	VRAY	0	$0	1,385,274	$10,503,489	0	$0

Yearly summary of insider trading at Orchard Therapeutics Plc (ORTX) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	ORTX	0	$0	2,045,510	$14,277,659	0	$0
2020	ORTX	0	$0	28,474	$383,829	0	$0

Yearly summary of insider trading at Metsera, Inc. (MTSR) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	MTSR	0	$0	268	$9,648	0	$0

Yearly summary of insider trading at Beam Therapeutics Inc. (BEAM) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	BEAM	0	$0	48,374	$991,667	0	$0
2024	BEAM	0	$0	901,565	$27,880,396	0	$0
2022	BEAM	0	$0	40,343	$2,248,993	0	$0

Yearly summary of insider trading at Verve Therapeutics, Inc. (VERV) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	VERV	0	$0	466,565	$11,289,109	0	$0

Yearly summary of insider trading at Aclaris Therapeutics, Inc. (ACRS) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2016	ACRS	0	$0	3,750	$82,650	0	$0
2015	ACRS	335,455	$3,690,005	0	$0	0	$0

Yearly summary of insider trading at Sana Biotechnology, Inc. (SANA) by Fmr Llc

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	SANA	0	$0	290,912	$1,933,110	0	$0

Insider trading activities at 14 companies by Fmr Llc:

1. Coherus Biosciences, Inc. (CHRS)

2. Regenxbio Inc. (RGNX)

3. Fidelity Private Credit Fund (NONE)

4. Cogent Biosciences, Inc. (UMRX)

5. Kineta, Inc./de (PTI)

6. Precision Biosciences Inc (DTIL)

7. Blueprint Medicines Corp (BPMC)

8. Viewray, Inc. (VRAY)

9. Orchard Therapeutics Plc (ORTX)

10. Metsera, Inc. (MTSR)

11. Beam Therapeutics Inc. (BEAM)

12. Verve Therapeutics, Inc. (VERV)

13. Aclaris Therapeutics, Inc. (ACRS)

14. Sana Biotechnology, Inc. (SANA)

Table 1. Insider trading of Coherus Biosciences, Inc. (CHRS) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-08-08	CHRS	Sale	100,000	29.88	2,987,800
2016-08-04	CHRS	Sale	23,600	27.99	660,516
2016-08-05	CHRS	Sale	25,000	28.78	719,500

Table 2. Insider trading of Regenxbio Inc. (RGNX) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-05-17	RGNX	Sale	18,300	12.41	227,103
2016-05-13	RGNX	Sale	5,530	11.27	62,306
2016-05-16	RGNX	Sale	10,500	11.95	125,517
2016-05-12	RGNX	Sale	6,711	10.90	73,176
2016-05-10	RGNX	Sale	10,943	10.11	110,677
2016-05-11	RGNX	Sale	14,189	10.63	150,885
2016-05-09	RGNX	Sale	5,731	9.91	56,777
2016-05-06	RGNX	Sale	4,839	9.95	48,167
2016-05-04	RGNX	Sale	1,896	10.47	19,860
2016-05-02	RGNX	Sale	2,396	10.85	25,996
2016-05-03	RGNX	Sale	3,650	10.76	39,266
2016-04-27	RGNX	Sale	28,278	11.19	316,289
2016-04-28	RGNX	Sale	4,918	11.31	55,627
2016-04-25	RGNX	Sale	3,888	11.29	43,895
2016-04-26	RGNX	Sale	5,300	11.12	58,935
2016-04-21	RGNX	Sale	3,200	11.28	36,096
2016-04-22	RGNX	Sale	17,358	11.30	196,145
2016-04-19	RGNX	Sale	8,989	11.77	105,800
2016-04-20	RGNX	Sale	4,200	11.42	47,964
2016-04-18	RGNX	Sale	9,600	11.94	114,624
2016-04-15	RGNX	Sale	9,300	11.56	107,508
2016-04-12	RGNX	Sale	2,302	11.44	26,334
2016-04-13	RGNX	Sale	20,000	11.44	228,800
2016-04-14	RGNX	Sale	4,734	11.57	54,772

Table 3. Insider trading of Fidelity Private Credit Fund (NONE) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-11-29	NONE	Buy	782	25.54	19,972
2023-06-27	NONE	Buy	346,722	25.23	8,747,796

Table 4. Insider trading of Cogent Biosciences, Inc. (UMRX) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-04-03	UMRX	Buy	94,052	12.00	1,128,624

Table 5. Insider trading of Kineta, Inc./de (PTI) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2017-03-13	PTI	Sale	25,000	12.94	323,500
2017-03-10	PTI	Sale	25,000	12.04	301,000
2017-03-08	PTI	Sale	25,000	12.10	302,500
2017-03-09	PTI	Sale	4,300	11.90	51,152
2017-03-06	PTI	Sale	25,000	13.31	332,750
2017-03-07	PTI	Sale	35,000	13.13	459,550
2017-03-03	PTI	Sale	20,000	13.63	272,600
2017-03-02	PTI	Sale	25,000	14.30	357,625
2017-02-28	PTI	Sale	15,000	14.47	217,050
2017-03-01	PTI	Sale	30,000	14.70	441,000
2017-02-24	PTI	Sale	13,000	14.55	189,150
2017-02-27	PTI	Sale	15,000	14.65	219,750
2016-02-17	PTI	Buy	375,000	8.00	3,000,000

Table 6. Insider trading of Precision Biosciences Inc (DTIL) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-04-01	DTIL	Buy	50,000	16.00	800,000

Table 7. Insider trading of Blueprint Medicines Corp (BPMC) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2015-11-25	BPMC	Sale	229,596	21.23	4,873,175
2015-11-27	BPMC	Sale	57,819	21.91	1,267,103
2015-11-24	BPMC	Sale	161,271	20.14	3,247,997
2015-11-20	BPMC	Sale	104,272	20.09	2,095,345
2015-11-23	BPMC	Sale	85,300	20.14	1,717,515
2015-11-18	BPMC	Sale	81,324	19.76	1,607,206
2015-11-19	BPMC	Sale	155,894	19.86	3,096,054
2015-11-17	BPMC	Sale	27,490	20.57	565,469
2015-11-16	BPMC	Sale	28,684	21.25	609,391
2015-05-05	BPMC	Buy	125,000	18.00	2,250,000

Table 8. Insider trading of Viewray, Inc. (VRAY) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-08-08	VRAY	Sale	200,000	10.02	2,004,000
2018-08-06	VRAY	Sale	147,329	10.60	1,561,392
2018-08-07	VRAY	Sale	26,600	10.19	271,054
2018-08-02	VRAY	Sale	79,522	12.04	957,206
2018-08-03	VRAY	Sale	255,153	11.36	2,897,262
2018-07-31	VRAY	Sale	60,872	12.10	736,551
2018-08-01	VRAY	Sale	66,334	12.02	797,003
2018-07-27	VRAY	Sale	148,565	11.58	1,720,382
2018-07-30	VRAY	Sale	110,000	11.45	1,259,830
2018-07-25	VRAY	Sale	77,039	11.97	922,542
2018-07-26	VRAY	Sale	218,811	12.35	2,701,659
2017-04-25	VRAY	Sale	106,781	6.75	720,344
2017-04-24	VRAY	Sale	77,634	6.63	514,868
2017-04-21	VRAY	Sale	23,505	6.87	161,479
2017-04-19	VRAY	Sale	28,264	6.95	196,350
2017-04-20	VRAY	Sale	72,972	6.95	507,301
2017-04-17	VRAY	Sale	89,700	7.53	675,261
2017-04-18	VRAY	Sale	17,517	7.10	124,370
2017-04-13	VRAY	Sale	115,860	7.52	871,614
2017-04-11	VRAY	Sale	81,814	7.49	612,786
2017-04-12	VRAY	Sale	97,680	7.41	723,808
2017-04-10	VRAY	Sale	178,556	7.72	1,377,916
2017-04-06	VRAY	Sale	3,100	7.73	23,963
2017-04-07	VRAY	Sale	48,950	7.96	389,446
2017-04-04	VRAY	Sale	132,767	7.95	1,055,497
2017-04-05	VRAY	Sale	63,630	7.80	496,314
2017-03-31	VRAY	Sale	113,877	8.61	980,253
2017-04-03	VRAY	Sale	104,006	7.97	829,447
2017-03-30	VRAY	Sale	28,661	8.46	242,472

Table 9. Insider trading of Orchard Therapeutics Plc (ORTX) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-02-05	ORTX	Sale	2,045,510	6.98	14,277,659
2020-01-02	ORTX	Sale	28,474	13.48	383,829

Table 10. Insider trading of Metsera, Inc. (MTSR) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-09-02	MTSR	Sale	268	36.00	9,648

Table 11. Insider trading of Beam Therapeutics Inc. (BEAM) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-07-30	BEAM	Sale	48,374	20.50	991,667
2024-02-13	BEAM	Sale	1,565	30.61	47,896
2024-02-14	BEAM	Sale	900,000	30.93	27,832,500
2022-09-06	BEAM	Sale	551	54.25	29,891
2022-08-05	BEAM	Sale	20,326	60.75	1,234,804
2022-04-13	BEAM	Sale	19,466	50.56	984,298

Table 12. Insider trading of Verve Therapeutics, Inc. (VERV) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-07-12	VERV	Sale	163,000	21.01	3,424,630
2022-07-01	VERV	Sale	38,775	15.66	607,216
2022-06-29	VERV	Sale	34,409	15.55	535,059
2022-06-30	VERV	Sale	18,810	15.21	286,100
2022-03-09	VERV	Sale	3,971	29.01	115,198
2022-02-09	VERV	Sale	13,190	29.46	388,577
2022-02-01	VERV	Sale	35,574	29.04	1,033,068
2022-01-26	VERV	Sale	149,853	30.92	4,633,005
2022-01-27	VERV	Sale	8,983	29.64	266,256

Table 13. Insider trading of Aclaris Therapeutics, Inc. (ACRS) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2016-10-26	ACRS	Sale	3,750	22.04	82,650
2015-10-13	ACRS	Buy	335,455	11.00	3,690,005

Table 14. Insider trading of Sana Biotechnology, Inc. (SANA) by Fmr Llc

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-01-08	SANA	Sale	290,912	6.64	1,933,110

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Fmr Llc (Officer of Metsera, Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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