The following table details the trading activities
(stock purchases, stock sales, and stock option exercises)
reported to
the Securities and Exchange Commission (SEC)
by insider Crooke Stanley T since year 2005.
The trader's CIK number is 897667.
At the time of the last reporting, Crooke Stanley T was the Chairman and CEO of Ionis Pharmaceuticals Inc .
(stock ticker symbol IONS).
See this page for all insider trading activities at Ionis Pharmaceuticals Inc .
| Trade Date | Symbol | Company Name (Issuer) | Trade Type | Shares | Price ($) | Value ($) |
|---|---|---|---|---|---|---|
| 2019-08-21 | IONS | Ionis Pharmaceuticals Inc | Sale | 10,000 | 72.15 | 721,500 |
| 2019-08-20 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 12,000 | 39.87 | 478,439 |
| 2019-08-21 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 10,000 | 39.87 | 398,700 |
| 2019-08-20 | IONS | Ionis Pharmaceuticals Inc | Sale | 12,000 | 71.00 | 852,000 |
| 2019-07-18 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 10,000 | 39.87 | 398,700 |
| 2019-07-18 | IONS | Ionis Pharmaceuticals Inc | Sale | 10,000 | 70.25 | 702,510 |
| 2019-04-15 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 12.76 | 140,305 |
| 2019-04-16 | IONS | Ionis Pharmaceuticals Inc | Sale | 21,000 | 84.70 | 1,778,763 |
| 2019-04-15 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 85.25 | 937,750 |
| 2019-04-16 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 21,000 | 26.31 | 552,573 |
| 2019-02-25 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 40,000 | 39.87 | 1,594,800 |
| 2019-02-26 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 37,000 | 39.87 | 1,475,190 |
| 2019-02-25 | IONS | Ionis Pharmaceuticals Inc | Sale | 40,000 | 60.07 | 2,402,720 |
| 2019-02-26 | IONS | Ionis Pharmaceuticals Inc | Sale | 37,000 | 61.53 | 2,276,795 |
| 2019-02-13 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 46,904 | 30.19 | 1,415,891 |
| 2019-02-13 | IONS | Ionis Pharmaceuticals Inc | Sale | 46,904 | 60.03 | 2,815,834 |
| 2019-01-15 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 32,933 | .00 | 0 |
| 2018-04-17 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 13,962 | 12.76 | 178,085 |
| 2018-04-17 | IONS | Ionis Pharmaceuticals Inc | Sale | 13,962 | 44.40 | 619,912 |
| 2018-01-15 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 31,334 | .00 | 0 |
| 2018-01-15 | IONS | Ionis Pharmaceuticals Inc | Sale | 16,549 | 51.76 | 856,576 |
| 2018-01-08 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 12.76 | 140,305 |
| 2018-01-08 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 52.01 | 572,110 |
| 2018-01-03 | IONS | Ionis Pharmaceuticals Inc | Sale | 22,000 | 49.92 | 1,098,174 |
| 2018-01-03 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 22,000 | 10.92 | 240,240 |
| 2017-10-13 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 16,500 | 10.97 | 181,005 |
| 2017-10-13 | IONS | Ionis Pharmaceuticals Inc | Sale | 16,500 | 59.46 | 981,090 |
| 2017-10-04 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 54.23 | 596,475 |
| 2017-10-04 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.97 | 120,670 |
| 2017-10-02 | IONS | Ionis Pharmaceuticals Inc | Sale | 16,500 | 52.00 | 858,000 |
| 2017-10-02 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 16,500 | 10.97 | 181,005 |
| 2017-07-20 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.97 | 120,670 |
| 2017-07-20 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 55.35 | 608,850 |
| 2017-07-17 | IONS | Ionis Pharmaceuticals Inc | Sale | 16,500 | 52.45 | 865,425 |
| 2017-07-17 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 16,500 | 10.97 | 181,005 |
| 2017-07-03 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 16,500 | 9.73 | 160,545 |
| 2017-07-03 | IONS | Ionis Pharmaceuticals Inc | Sale | 16,500 | 52.16 | 860,640 |
| 2017-04-25 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 16,500 | 7.25 | 119,625 |
| 2017-04-25 | IONS | Ionis Pharmaceuticals Inc | Sale | 16,500 | 47.81 | 788,865 |
| 2017-04-19 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 5,500 | 7.25 | 39,875 |
| 2017-04-19 | IONS | Ionis Pharmaceuticals Inc | Sale | 5,500 | 43.25 | 237,875 |
| 2017-04-13 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 41.30 | 454,299 |
| 2017-04-12 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 40.07 | 440,770 |
| 2017-04-13 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 8.26 | 90,893 |
| 2017-04-12 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 8.77 | 96,470 |
| 2017-03-02 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 12,100 | 8.77 | 106,117 |
| 2017-03-02 | IONS | Ionis Pharmaceuticals Inc | Sale | 12,100 | 51.05 | 617,705 |
| 2017-01-15 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 29,834 | .00 | 0 |
| 2017-01-17 | IONS | Ionis Pharmaceuticals Inc | Sale | 15,957 | 46.29 | 738,649 |
| 2017-01-10 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 13,200 | 8.77 | 115,764 |
| 2017-01-10 | IONS | Ionis Pharmaceuticals Inc | Sale | 13,200 | 49.25 | 650,100 |
| 2017-01-03 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 8.77 | 96,470 |
| 2017-01-04 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 7,700 | 8.77 | 67,529 |
| 2017-01-03 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 48.05 | 528,550 |
| 2017-01-04 | IONS | Ionis Pharmaceuticals Inc | Sale | 7,700 | 50.10 | 385,770 |
| 2016-11-10 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 41.23 | 453,475 |
| 2016-11-09 | IONS | Ionis Pharmaceuticals Inc | Sale | 22,000 | 36.50 | 803,000 |
| 2016-11-10 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 8.77 | 96,470 |
| 2016-11-09 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 22,000 | 9.68 | 213,004 |
| 2016-10-05 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.29 | 113,189 |
| 2016-10-05 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 36.61 | 402,710 |
| 2016-09-27 | IONS | Ionis Pharmaceuticals Inc | Sale | 22,000 | 36.03 | 792,769 |
| 2016-09-27 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 22,000 | 10.29 | 226,379 |
| 2016-09-21 | IONS | Ionis Pharmaceuticals Inc | Sale | 22,000 | 35.50 | 781,000 |
| 2016-09-21 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 22,000 | 10.29 | 226,379 |
| 2016-04-06 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.29 | 113,189 |
| 2016-04-06 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 46.12 | 507,375 |
| 2016-03-31 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 40.73 | 448,085 |
| 2016-03-31 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.02 | 110,242 |
| 2016-01-15 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 24,661 | .00 | 0 |
| 2016-01-19 | IONS | Ionis Pharmaceuticals Inc | Sale | 13,401 | 41.46 | 555,605 |
| 2016-01-05 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 5,500 | 9.76 | 53,652 |
| 2016-01-05 | IONS | Ionis Pharmaceuticals Inc | Sale | 5,500 | 62.10 | 341,550 |
| 2016-01-04 | IONS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 9.76 | 107,305 |
| 2016-01-04 | IONS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 61.05 | 671,550 |
| 2015-10-23 | ISIS | Ionis Pharmaceuticals Inc | Sale | 27,500 | 44.57 | 1,225,675 |
| 2015-10-23 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 27,500 | 10.06 | 276,595 |
| 2015-10-21 | ISIS | Ionis Pharmaceuticals Inc | Sale | 16,500 | 43.00 | 709,500 |
| 2015-10-21 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 16,500 | 10.59 | 174,685 |
| 2015-07-06 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 6,175 | 10.24 | 63,262 |
| 2015-07-06 | ISIS | Ionis Pharmaceuticals Inc | Sale | 6,175 | 57.01 | 352,018 |
| 2015-07-01 | ISIS | Ionis Pharmaceuticals Inc | Sale | 6,175 | 57.56 | 355,439 |
| 2015-07-01 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 6,175 | 10.24 | 63,262 |
| 2015-04-07 | ISIS | Ionis Pharmaceuticals Inc | Sale | 22,377 | 63.07 | 1,411,339 |
| 2015-04-07 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 22,377 | 10.24 | 229,252 |
| 2015-04-01 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 21,623 | 10.24 | 221,527 |
| 2015-04-01 | ISIS | Ionis Pharmaceuticals Inc | Sale | 21,623 | 61.93 | 1,339,155 |
| 2015-01-27 | ISIS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 72.93 | 802,186 |
| 2015-01-27 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.24 | 112,694 |
| 2015-01-15 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 17,425 | .00 | 0 |
| 2015-01-16 | ISIS | Ionis Pharmaceuticals Inc | Sale | 9,054 | 67.96 | 615,346 |
| 2015-01-09 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.24 | 112,694 |
| 2015-01-09 | ISIS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 73.57 | 809,269 |
| 2015-01-06 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.24 | 112,694 |
| 2015-01-07 | ISIS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 68.05 | 748,528 |
| 2015-01-06 | ISIS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 66.04 | 726,418 |
| 2015-01-07 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 10.24 | 112,694 |
| 2014-10-23 | ISIS | Ionis Pharmaceuticals Inc | Sale | 14,600 | 42.22 | 616,412 |
| 2014-10-23 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 14,600 | 11.65 | 170,133 |
| 2014-10-01 | ISIS | Ionis Pharmaceuticals Inc | Sale | 22,000 | 37.91 | 834,042 |
| 2014-10-03 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 14,000 | 11.85 | 165,830 |
| 2014-10-03 | ISIS | Ionis Pharmaceuticals Inc | Sale | 14,000 | 39.49 | 552,818 |
| 2014-10-01 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 22,000 | 11.65 | 256,366 |
| 2014-08-13 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 17,100 | 12.87 | 220,077 |
| 2014-08-13 | ISIS | Ionis Pharmaceuticals Inc | Sale | 17,100 | 35.45 | 606,263 |
| 2014-08-01 | ISIS | Ionis Pharmaceuticals Inc | Sale | 16,000 | 30.52 | 488,400 |
| 2014-08-01 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 16,000 | 12.87 | 205,920 |
| 2014-07-01 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 17,500 | 13.40 | 234,552 |
| 2014-07-01 | ISIS | Ionis Pharmaceuticals Inc | Sale | 17,500 | 35.56 | 622,282 |
| 2014-06-19 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 14.47 | 159,170 |
| 2014-06-19 | ISIS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 35.10 | 386,111 |
| 2014-06-10 | ISIS | Ionis Pharmaceuticals Inc | Sale | 11,000 | 33.45 | 368,005 |
| 2014-06-10 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 11,000 | 14.47 | 159,170 |
| 2014-04-02 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 8,800 | 14.47 | 127,336 |
| 2014-04-02 | ISIS | Ionis Pharmaceuticals Inc | Sale | 8,800 | 43.65 | 384,102 |
| 2014-01-15 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 9,260 | .00 | 0 |
| 2014-01-16 | ISIS | Ionis Pharmaceuticals Inc | Sale | 3,527 | 47.08 | 166,054 |
| 2014-01-08 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 12,500 | 14.47 | 180,875 |
| 2014-01-08 | ISIS | Ionis Pharmaceuticals Inc | Sale | 12,500 | 40.05 | 500,650 |
| 2014-01-02 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 31,500 | 14.47 | 455,805 |
| 2014-01-02 | ISIS | Ionis Pharmaceuticals Inc | Sale | 31,500 | 39.50 | 1,244,313 |
| 2013-09-19 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 50,000 | 11.12 | 556,000 |
| 2013-09-20 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 8,740 | 11.12 | 97,188 |
| 2013-09-19 | ISIS | Ionis Pharmaceuticals Inc | Sale | 50,000 | 35.07 | 1,753,600 |
| 2013-09-20 | ISIS | Ionis Pharmaceuticals Inc | Sale | 8,740 | 35.90 | 313,748 |
| 2013-09-11 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 31.18 | 623,620 |
| 2013-09-09 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 26,615 | 11.12 | 295,958 |
| 2013-09-09 | ISIS | Ionis Pharmaceuticals Inc | Sale | 26,615 | 30.41 | 809,495 |
| 2013-09-10 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 31.65 | 949,440 |
| 2013-07-23 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 11,500 | 11.12 | 127,879 |
| 2013-07-23 | ISIS | Ionis Pharmaceuticals Inc | Sale | 11,500 | 30.00 | 345,000 |
| 2013-07-18 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 11.12 | 222,399 |
| 2013-07-22 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 30.86 | 617,100 |
| 2013-07-22 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 13.96 | 279,200 |
| 2013-07-19 | ISIS | Ionis Pharmaceuticals Inc | Sale | 22,200 | 30.82 | 684,181 |
| 2013-07-18 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 30.11 | 602,220 |
| 2013-07-19 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 22,200 | 15.38 | 341,436 |
| 2013-07-16 | ISIS | Ionis Pharmaceuticals Inc | Sale | 6,000 | 33.31 | 199,842 |
| 2013-07-17 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 13,300 | 13.56 | 180,348 |
| 2013-07-15 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 33.81 | 1,014,179 |
| 2013-07-16 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 6,000 | 11.12 | 66,720 |
| 2013-07-15 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 11.12 | 333,600 |
| 2013-07-17 | ISIS | Ionis Pharmaceuticals Inc | Sale | 13,300 | 31.71 | 421,782 |
| 2013-07-12 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 33.14 | 994,140 |
| 2013-07-11 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 32.00 | 960,090 |
| 2013-07-12 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 12.54 | 376,200 |
| 2013-07-10 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 30.05 | 901,440 |
| 2013-07-11 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 15.38 | 461,400 |
| 2013-07-10 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 15.38 | 461,400 |
| 2013-07-05 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 24,180 | 15.38 | 371,888 |
| 2013-07-09 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 30.04 | 901,290 |
| 2013-07-08 | ISIS | Ionis Pharmaceuticals Inc | Sale | 54,992 | 25.16 | 1,383,873 |
| 2013-07-09 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 15.38 | 461,400 |
| 2013-07-08 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 5,008 | 15.38 | 77,023 |
| 2013-07-05 | ISIS | Ionis Pharmaceuticals Inc | Sale | 24,180 | 30.02 | 725,762 |
| 2013-07-01 | ISIS | Ionis Pharmaceuticals Inc | Sale | 10,000 | 28.17 | 281,700 |
| 2013-06-28 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,683 | 27.23 | 563,198 |
| 2013-06-27 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 27.85 | 557,000 |
| 2013-06-28 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,683 | 8.25 | 170,572 |
| 2013-06-27 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 6.81 | 136,200 |
| 2013-06-26 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 26.90 | 807,030 |
| 2013-06-25 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 28.09 | 842,790 |
| 2013-06-26 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 6.81 | 136,200 |
| 2013-06-24 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 25.19 | 755,700 |
| 2013-06-25 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 6.81 | 204,300 |
| 2013-04-24 | ISIS | Ionis Pharmaceuticals Inc | Sale | 10,000 | 22.12 | 221,200 |
| 2013-04-23 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 22.10 | 662,910 |
| 2013-04-22 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 20.99 | 629,700 |
| 2013-04-22 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 7.26 | 145,200 |
| 2013-04-19 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 20.01 | 600,180 |
| 2013-04-19 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 7.26 | 217,800 |
| 2013-01-15 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 3,295 | .00 | 0 |
| 2013-01-16 | ISIS | Ionis Pharmaceuticals Inc | Sale | 1,460 | 14.00 | 20,440 |
| 2012-10-10 | RGLS | Regulus Therapeutics Inc. | Buy | 750,000 | 4.00 | 3,000,000 |
| 2012-09-20 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 6.04 | 181,350 |
| 2012-09-19 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 5.25 | 157,500 |
| 2012-09-21 | ISIS | Ionis Pharmaceuticals Inc | Sale | 29,462 | 14.06 | 414,235 |
| 2012-09-20 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 15.01 | 450,240 |
| 2012-09-19 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 14.81 | 444,450 |
| 2012-09-21 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 29,462 | 6.84 | 201,520 |
| 2012-09-13 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 27,074 | 5.25 | 142,138 |
| 2012-09-13 | ISIS | Ionis Pharmaceuticals Inc | Sale | 27,074 | 14.55 | 393,926 |
| 2012-09-05 | ISIS | Ionis Pharmaceuticals Inc | Sale | 15,000 | 14.82 | 222,345 |
| 2012-09-06 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 5.51 | 165,450 |
| 2012-09-04 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 14.11 | 423,240 |
| 2012-09-05 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 15,000 | 5.25 | 78,750 |
| 2012-09-04 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 5.25 | 157,500 |
| 2012-09-06 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 15.02 | 450,540 |
| 2011-12-21 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 17,800 | 5.80 | 103,240 |
| 2011-12-21 | ISIS | Ionis Pharmaceuticals Inc | Sale | 17,800 | 6.92 | 123,176 |
| 2011-12-20 | ISIS | Ionis Pharmaceuticals Inc | Sale | 28,700 | 6.87 | 197,169 |
| 2011-12-19 | ISIS | Ionis Pharmaceuticals Inc | Sale | 18,100 | 6.86 | 124,166 |
| 2011-12-20 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 28,700 | 5.80 | 166,460 |
| 2011-12-19 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 18,100 | 5.80 | 104,980 |
| 2011-12-16 | ISIS | Ionis Pharmaceuticals Inc | Sale | 16,500 | 6.79 | 112,035 |
| 2011-12-16 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 16,500 | 5.80 | 95,700 |
| 2010-12-29 | ISIS | Ionis Pharmaceuticals Inc | Sale | 12,000 | 10.31 | 123,780 |
| 2010-12-27 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 9.62 | 192,500 |
| 2010-12-27 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 10.42 | 208,400 |
| 2010-12-29 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 12,000 | 9.62 | 115,500 |
| 2010-12-22 | ISIS | Ionis Pharmaceuticals Inc | Sale | 16,000 | 10.52 | 168,320 |
| 2010-12-23 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 4,000 | 9.62 | 38,500 |
| 2010-12-22 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 16,000 | 9.62 | 154,000 |
| 2010-12-23 | ISIS | Ionis Pharmaceuticals Inc | Sale | 4,000 | 10.53 | 42,100 |
| 2009-12-30 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 6,535 | 6.81 | 44,503 |
| 2009-12-30 | ISIS | Ionis Pharmaceuticals Inc | Sale | 6,535 | 11.06 | 72,309 |
| 2009-12-22 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 10.13 | 202,600 |
| 2009-12-22 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 6.81 | 136,260 |
| 2009-12-16 | ISIS | Ionis Pharmaceuticals Inc | Sale | 23,465 | 10.11 | 237,113 |
| 2009-12-15 | ISIS | Ionis Pharmaceuticals Inc | Sale | 26,535 | 10.03 | 266,146 |
| 2009-12-16 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 23,465 | 6.81 | 159,867 |
| 2009-12-15 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 26,535 | 6.81 | 180,782 |
| 2009-12-11 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 6.81 | 136,260 |
| 2009-12-10 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 6.81 | 204,390 |
| 2009-12-14 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 9.86 | 197,200 |
| 2009-12-14 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 6.81 | 136,260 |
| 2009-12-11 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 9.98 | 199,600 |
| 2009-12-10 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 10.15 | 304,500 |
| 2009-12-08 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 10.53 | 315,900 |
| 2009-12-09 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 6.81 | 136,240 |
| 2009-12-08 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 6.81 | 204,360 |
| 2009-12-09 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 10.26 | 205,200 |
| 2009-12-04 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 6.81 | 204,360 |
| 2009-12-04 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 10.55 | 316,500 |
| 2009-12-07 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 6.81 | 204,360 |
| 2009-12-07 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 10.52 | 315,600 |
| 2008-12-30 | ISIS | Ionis Pharmaceuticals Inc | Sale | 7,500 | 13.37 | 100,267 |
| 2008-12-30 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 7,500 | 12.94 | 97,027 |
| 2008-12-23 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 9,800 | 12.94 | 126,782 |
| 2008-12-23 | ISIS | Ionis Pharmaceuticals Inc | Sale | 9,800 | 13.52 | 132,486 |
| 2008-12-26 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 7,500 | 12.94 | 97,027 |
| 2008-12-26 | ISIS | Ionis Pharmaceuticals Inc | Sale | 7,500 | 13.25 | 99,375 |
| 2008-12-19 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 13,000 | 12.94 | 168,181 |
| 2008-12-19 | ISIS | Ionis Pharmaceuticals Inc | Sale | 13,000 | 13.93 | 181,038 |
| 2008-12-17 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 12,173 | 5.15 | 62,690 |
| 2008-12-17 | ISIS | Ionis Pharmaceuticals Inc | Sale | 12,173 | 12.80 | 155,850 |
| 2007-12-26 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 24,000 | 12.31 | 295,488 |
| 2007-12-28 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 12.31 | 246,240 |
| 2007-12-26 | ISIS | Ionis Pharmaceuticals Inc | Sale | 24,000 | 16.52 | 396,599 |
| 2007-12-27 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 8,100 | 12.31 | 99,727 |
| 2007-12-28 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 16.22 | 324,420 |
| 2007-12-27 | ISIS | Ionis Pharmaceuticals Inc | Sale | 6,000 | 16.32 | 97,926 |
| 2007-12-11 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 20,000 | 12.31 | 246,240 |
| 2007-12-11 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 17.37 | 347,480 |
| 2007-11-30 | ISIS | Ionis Pharmaceuticals Inc | Sale | 29,851 | 18.03 | 538,153 |
| 2007-11-28 | ISIS | Ionis Pharmaceuticals Inc | Sale | 30,000 | 18.01 | 540,330 |
| 2007-11-30 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 29,851 | 5.15 | 153,732 |
| 2007-11-28 | ISIS | Ionis Pharmaceuticals Inc | Option Ex | 30,000 | 5.15 | 154,500 |
| 2006-11-13 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 13.36 | 267,200 |
| 2006-11-09 | ISIS | Ionis Pharmaceuticals Inc | Sale | 20,000 | 10.13 | 202,600 |
| 2006-11-10 | ISIS | Ionis Pharmaceuticals Inc | Sale | 10,000 | 10.40 | 104,050 |
Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Crooke Stanley T (Chairman and CEO of Ionis Pharmaceuticals Inc at the time of this reporting) see the Securities and Exchange Commission (SEC) website.