Insider trading activities (stock purchases, sales, and option exercises)
reported by insiders of Medicines Co /de (MDCO)
since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Medicines Co /de since year 2005.
Table 2 shows the detailed insider transactions of Medicines Co /de since 2005.
The reporting company's ticker symbol is MDCO. The reporting company's CIK number is 1113481.
The total value of stock buying since 2005 is $101,194,249.
The total value of stock sales since 2005 is $106,316,538.
The total value of stock option exercises since 2005 is $51,433,052.
| Trading Period | Insider Buying | Insider Sales | Option Exercises | |||
|---|---|---|---|---|---|---|
| year-month | Shares | Value | Shares | Value | Shares | Value |
| 2019-03 | 855,000 | $21,708,554 | 0 | $0 | 0 | $0 |
| 2018-12 | 1,002,289 | $19,872,305 | 0 | $0 | 0 | $0 |
| 2018-11 | 50,300 | $992,419 | 0 | $0 | 0 | $0 |
| 2018-09 | 0 | $0 | 50,000 | $1,965,500 | 0 | $0 |
| 2018-08 | 0 | $0 | 50,000 | $1,962,000 | 0 | $0 |
| 2018-07 | 0 | $0 | 50,000 | $1,803,500 | 0 | $0 |
| 2018-05 | 0 | $0 | 7,500 | $241,500 | 15,000 | $274,500 |
| 2018-04 | 0 | $0 | 10,000 | $300,500 | 0 | $0 |
| 2018-03 | 0 | $0 | 7,500 | $241,949 | 15,000 | $274,500 |
| 2018-01 | 0 | $0 | 10,000 | $273,700 | 0 | $0 |
| 2017-12 | 200,000 | $5,311,000 | 136,250 | $3,711,450 | 200,920 | $3,889,811 |
| 2017-11 | 173,215 | $5,204,668 | 0 | $0 | 47,798 | $701,770 |
| 2017-05 | 0 | $0 | 0 | $0 | 22,500 | $441,000 |
| 2017-03 | 0 | $0 | 0 | $0 | 15,000 | $294,000 |
| 2017-02 | 0 | $0 | 83,335 | $4,070,810 | 83,335 | $2,111,921 |
| 2016-12 | 727,220 | $24,470,472 | 0 | $0 | 40,000 | $1,144,000 |
| 2016-11 | 0 | $0 | 20,000 | $800,060 | 20,000 | $572,000 |
| 2016-09 | 0 | $0 | 10,000 | $400,000 | 10,000 | $285,999 |
| 2016-08 | 0 | $0 | 20,000 | $800,000 | 20,000 | $572,000 |
| 2016-07 | 0 | $0 | 3,849 | $148,186 | 0 | $0 |
| 2016-06 | 99,325 | $3,743,141 | 60,000 | $2,205,600 | 60,000 | $1,572,000 |
| 2016-05 | 300,000 | $10,104,000 | 50,000 | $1,801,795 | 50,000 | $1,030,000 |
| 2016-03 | 0 | $0 | 16,717 | $579,371 | 15,000 | $279,000 |
| 2016-02 | 0 | $0 | 0 | $0 | 15,000 | $279,000 |
| 2015-11 | 0 | $0 | 5,000 | $196,700 | 5,000 | $93,000 |
| 2015-09 | 0 | $0 | 25,000 | $1,050,000 | 25,000 | $551,000 |
| 2015-08 | 0 | $0 | 236,611 | $9,263,505 | 236,611 | $4,660,383 |
| 2015-07 | 0 | $0 | 16,667 | $473,242 | 16,667 | $304,506 |
| 2015-06 | 0 | $0 | 27,472 | $791,627 | 16,667 | $304,506 |
| 2015-05 | 0 | $0 | 74,142 | $1,971,278 | 91,667 | $1,913,256 |
| 2015-04 | 0 | $0 | 17,948 | $498,022 | 16,667 | $304,506 |
| 2015-03 | 0 | $0 | 81,928 | $2,445,604 | 36,667 | $758,006 |
| 2014-03 | 0 | $0 | 2,968 | $89,960 | 0 | $0 |
| 2014-02 | 0 | $0 | 10,000 | $342,920 | 0 | $0 |
| 2014-01 | 0 | $0 | 224,694 | $8,699,863 | 214,311 | $4,627,658 |
| 2013-12 | 0 | $0 | 50,616 | $1,893,096 | 21,016 | $575,004 |
| 2013-11 | 0 | $0 | 170,190 | $6,286,252 | 158,523 | $4,192,946 |
| 2013-10 | 0 | $0 | 39,428 | $1,388,558 | 31,354 | $504,662 |
| 2013-09 | 0 | $0 | 81,894 | $2,804,270 | 73,500 | $2,080,785 |
| 2013-08 | 0 | $0 | 7,500 | $234,450 | 0 | $0 |
| 2013-07 | 0 | $0 | 43,500 | $1,422,375 | 36,000 | $855,720 |
| 2013-06 | 0 | $0 | 109,973 | $3,660,671 | 109,973 | $2,008,106 |
| 2013-05 | 0 | $0 | 83,613 | $2,899,835 | 89,654 | $1,681,178 |
| 2013-04 | 0 | $0 | 7,500 | $250,274 | 1,667 | $28,655 |
| 2013-03 | 0 | $0 | 57,009 | $1,872,887 | 45,759 | $909,210 |
| 2013-02 | 0 | $0 | 73,004 | $2,308,262 | 24,046 | $494,929 |
| 2013-01 | 0 | $0 | 236,527 | $6,995,875 | 221,746 | $4,110,646 |
| 2012-12 | 0 | $0 | 31,500 | $688,040 | 20,000 | $343,800 |
| 2012-11 | 0 | $0 | 13,593 | $285,724 | 13,593 | $210,691 |
| 2012-10 | 0 | $0 | 13,600 | $314,024 | 13,600 | $210,800 |
| 2012-09 | 0 | $0 | 14,159 | $372,372 | 13,600 | $210,800 |
| 2012-08 | 0 | $0 | 70,751 | $1,779,344 | 53,100 | $888,700 |
| 2012-07 | 0 | $0 | 98,607 | $2,314,718 | 93,607 | $1,547,408 |
| 2012-06 | 0 | $0 | 5,000 | $108,600 | 0 | $0 |
| 2012-05 | 9,150 | $200,385 | 5,000 | $110,800 | 0 | $0 |
| 2012-04 | 0 | $0 | 32,500 | $691,600 | 38,750 | $329,087 |
| 2012-03 | 0 | $0 | 6,665 | $142,115 | 8,125 | $68,393 |
| 2012-02 | 0 | $0 | 35,265 | $741,967 | 5,625 | $50,218 |
| 2012-01 | 0 | $0 | 5,625 | $109,586 | 625 | $4,568 |
| 2011-12 | 0 | $0 | 22,956 | $444,548 | 625 | $4,568 |
| 2011-11 | 0 | $0 | 6,760 | $127,263 | 625 | $4,568 |
| 2011-10 | 0 | $0 | 3,125 | $54,362 | 625 | $4,568 |
| 2011-09 | 0 | $0 | 1,250 | $18,887 | 1,250 | $9,136 |
| 2011-07 | 0 | $0 | 3,125 | $52,281 | 625 | $4,568 |
| 2011-06 | 0 | $0 | 3,125 | $58,125 | 625 | $4,568 |
| 2011-05 | 0 | $0 | 15,354 | $268,840 | 8,125 | $108,068 |
| 2011-04 | 0 | $0 | 547,990 | $8,948,816 | 0 | $0 |
| 2011-03 | 0 | $0 | 207,717 | $3,427,379 | 0 | $0 |
| 2011-02 | 0 | $0 | 109,190 | $1,877,137 | 21,875 | $201,906 |
| 2010-09 | 88,049 | $1,152,561 | 0 | $0 | 0 | $0 |
| 2010-08 | 667,040 | $8,037,832 | 10,127 | $121,220 | 0 | $0 |
| 2010-05 | 0 | $0 | 6,250 | $46,625 | 0 | $0 |
| 2010-04 | 0 | $0 | 175,250 | $1,316,127 | 237,000 | $1,135,230 |
| 2009-05 | 2,000 | $14,154 | 0 | $0 | 0 | $0 |
| 2009-03 | 0 | $0 | 3,125 | $31,181 | 0 | $0 |
| 2008-12 | 5,000 | $61,395 | 0 | $0 | 0 | $0 |
| 2008-11 | 2,000 | $24,484 | 0 | $0 | 0 | $0 |
| 2008-03 | 0 | $0 | 3,125 | $59,456 | 0 | $0 |
| 2007-08 | 12,000 | $184,310 | 0 | $0 | 0 | $0 |
| 2007-07 | 0 | $0 | 1,000 | $20,000 | 0 | $0 |
| 2007-06 | 0 | $0 | 1,000 | $20,000 | 0 | $0 |
| 2007-05 | 1,000 | $21,740 | 1,000 | $22,704 | 0 | $0 |
| 2007-04 | 0 | $0 | 2,000 | $50,928 | 0 | $0 |
| 2007-03 | 0 | $0 | 5,125 | $132,560 | 0 | $0 |
| 2007-02 | 0 | $0 | 2,000 | $61,280 | 0 | $0 |
| 2007-01 | 0 | $0 | 52,000 | $1,658,750 | 68,333 | $1,228,644 |
| 2006-12 | 0 | $0 | 2,000 | $57,302 | 0 | $0 |
| 2006-11 | 0 | $0 | 2,000 | $51,152 | 0 | $0 |
| 2006-10 | 0 | $0 | 12,000 | $292,750 | 10,000 | $91,300 |
| 2006-09 | 0 | $0 | 1,000 | $22,565 | 0 | $0 |
| 2006-08 | 0 | $0 | 6,000 | $130,683 | 5,000 | $45,650 |
| 2006-07 | 0 | $0 | 1,000 | $20,000 | 0 | $0 |
| 2006-02 | 0 | $0 | 5,964 | $119,280 | 5,000 | $45,650 |
| 2005-10 | 2,900 | $48,841 | 0 | $0 | 0 | $0 |
| 2005-07 | 2,000 | $41,988 | 0 | $0 | 0 | $0 |
| Trade Date | Insider Name | Trade Type | Shares | Price ($) | Value ($) |
|---|---|---|---|---|---|
| 2019-03-06 | Denner Alexander J | Buy | 248,100 | 24.91 | 6,180,171 |
| 2019-03-05 | Denner Alexander J | Buy | 181,900 | 26.07 | 4,742,133 |
| 2019-03-04 | Denner Alexander J | Buy | 325,000 | 25.45 | 8,271,250 |
| 2019-03-01 | Denner Alexander J | Buy | 100,000 | 25.15 | 2,515,000 |
| 2018-12-21 | Timney Mark (Chief Executive Officer) | Buy | 2,926 | 17.90 | 52,375 |
| 2018-12-20 | Cox Christopher T (EVP & Chief Corp. Dev. Officer) | Buy | 113,500 | 17.70 | 2,008,950 |
| 2018-12-20 | Denner Alexander J | Buy | 10,000 | 17.89 | 178,900 |
| 2018-12-18 | Denner Alexander J | Buy | 10,000 | 18.18 | 181,800 |
| 2018-12-17 | Timney Mark (Chief Executive Officer) | Buy | 26,863 | 18.60 | 499,651 |
| 2018-12-17 | Denner Alexander J | Buy | 20,000 | 17.91 | 358,200 |
| 2018-12-14 | Denner Alexander J | Buy | 219,000 | 18.97 | 4,154,429 |
| 2018-12-13 | Denner Alexander J | Buy | 600,000 | 20.73 | 12,438,000 |
| 2018-11-16 | Cox Christopher T (EVP & Chief Corp. Dev. Officer) | Buy | 50,300 | 19.73 | 992,419 |
| 2018-09-04 | Meanwell Clive (CEO) | Sale | 50,000 | 39.31 | 1,965,500 |
| 2018-08-01 | Meanwell Clive (CEO) | Sale | 50,000 | 39.24 | 1,962,000 |
| 2018-07-02 | Meanwell Clive (CEO) | Sale | 50,000 | 36.07 | 1,803,500 |
| 2018-05-25 | Spigelman Melvin K | Sale | 7,500 | 32.20 | 241,500 |
| 2018-05-25 | Spigelman Melvin K | Option Ex | 7,500 | 18.30 | 137,250 |
| 2018-05-10 | Kessler Armin M | Option Ex | 7,500 | 18.30 | 137,250 |
| 2018-04-16 | Kessler Armin M | Sale | 10,000 | 30.05 | 300,500 |
| 2018-03-22 | Wyatt Elizabeth H S | Option Ex | 7,500 | 18.30 | 137,250 |
| 2018-03-21 | Crouse William | Sale | 7,500 | 32.26 | 241,949 |
| 2018-03-21 | Crouse William | Option Ex | 7,500 | 18.30 | 137,250 |
| 2018-01-16 | Kessler Armin M | Sale | 10,000 | 27.37 | 273,700 |
| 2017-12-15 | Meanwell Clive (CEO) | Sale | 136,250 | 27.24 | 3,711,450 |
| 2017-12-15 | Meanwell Clive (CEO) | Option Ex | 200,920 | 19.36 | 3,889,811 |
| 2017-12-08 | Eshelman Fredric N (Executive Chairman) | Buy | 100,000 | 26.65 | 2,665,000 |
| 2017-12-07 | Eshelman Fredric N (Executive Chairman) | Buy | 100,000 | 26.46 | 2,646,000 |
| 2017-11-30 | Panayiotopoulos Paris | Buy | 3,215 | 30.97 | 99,568 |
| 2017-11-29 | Denner Alexander J (Director) | Buy | 170,000 | 30.03 | 5,105,100 |
| 2017-11-09 | Hugin Robert J | Option Ex | 47,798 | 14.68 | 701,770 |
| 2017-05-23 | Spigelman Melvin K | Option Ex | 7,500 | 19.60 | 147,000 |
| 2017-05-16 | Wyatt Elizabeth H S | Option Ex | 7,500 | 19.60 | 147,000 |
| 2017-05-12 | Crouse William | Option Ex | 7,500 | 19.60 | 147,000 |
| 2017-03-13 | Kessler Armin M | Option Ex | 7,500 | 19.60 | 147,000 |
| 2017-03-08 | Hugin Robert J | Option Ex | 7,500 | 19.60 | 147,000 |
| 2017-02-10 | O'connor William Bernard (Chief Financial Officer) | Sale | 57,502 | 50.00 | 2,875,100 |
| 2017-02-10 | O'connor William Bernard (Chief Financial Officer) | Option Ex | 57,502 | 25.11 | 1,444,162 |
| 2017-02-07 | O'connor William Bernard (Chief Financial Officer) | Sale | 15,000 | 47.22 | 708,225 |
| 2017-02-07 | O'connor William Bernard (Chief Financial Officer) | Option Ex | 15,000 | 28.60 | 429,000 |
| 2017-02-03 | O'connor William Bernard (Chief Financial Officer) | Sale | 10,833 | 45.00 | 487,485 |
| 2017-02-03 | O'connor William Bernard (Chief Financial Officer) | Option Ex | 10,833 | 22.04 | 238,759 |
| 2016-12-08 | Cox Christopher T (EVP & Chief Corp. Dev. Officer) | Buy | 16,500 | 32.52 | 536,580 |
| 2016-12-08 | Eshelman Fredric N | Buy | 24,689 | 32.85 | 811,033 |
| 2016-12-07 | Cox Christopher T (EVP & Chief Corp. Dev. Officer) | Buy | 89,000 | 33.33 | 2,966,370 |
| 2016-12-07 | Meanwell Clive (CEO) | Option Ex | 40,000 | 28.60 | 1,144,000 |
| 2016-12-07 | Eshelman Fredric N | Buy | 259,351 | 33.26 | 8,624,717 |
| 2016-12-06 | Eshelman Fredric N | Buy | 337,680 | 34.15 | 11,531,772 |
| 2016-11-15 | Meanwell Clive (CEO) | Sale | 20,000 | 40.00 | 800,060 |
| 2016-11-15 | Meanwell Clive (CEO) | Option Ex | 20,000 | 28.60 | 572,000 |
| 2016-09-21 | Meanwell Clive (CEO) | Sale | 8,623 | 40.00 | 344,920 |
| 2016-09-21 | Meanwell Clive (CEO) | Option Ex | 8,623 | 28.60 | 246,617 |
| 2016-09-01 | Meanwell Clive (CEO) | Sale | 1,377 | 40.00 | 55,080 |
| 2016-09-01 | Meanwell Clive (CEO) | Option Ex | 1,377 | 28.60 | 39,382 |
| 2016-08-24 | Meanwell Clive (CEO) | Sale | 20,000 | 40.00 | 800,000 |
| 2016-08-24 | Meanwell Clive (CEO) | Option Ex | 20,000 | 28.60 | 572,000 |
| 2016-07-11 | Shigeta Hiroaki | Sale | 3,849 | 38.50 | 148,186 |
| 2016-06-13 | Shigeta Hiroaki | Sale | 40,000 | 36.76 | 1,470,400 |
| 2016-06-13 | Shigeta Hiroaki | Option Ex | 40,000 | 26.20 | 1,048,000 |
| 2016-06-10 | Cox Christopher T (EVP & Chief Corp. Dev. Officer) | Buy | 20,010 | 37.22 | 744,672 |
| 2016-06-08 | Cox Christopher T (EVP & Chief Corp. Dev. Officer) | Buy | 25,975 | 38.43 | 998,219 |
| 2016-06-07 | Cox Christopher T (EVP & Chief Corp. Dev. Officer) | Buy | 53,340 | 37.50 | 2,000,250 |
| 2016-05-24 | Spigelman Melvin K | Sale | 15,000 | 37.00 | 555,000 |
| 2016-05-24 | Spigelman Melvin K | Option Ex | 15,000 | 18.60 | 279,000 |
| 2016-05-24 | Savage Robert G. | Sale | 10,000 | 36.95 | 369,500 |
| 2016-05-24 | Savage Robert G. | Option Ex | 10,000 | 18.60 | 186,000 |
| 2016-05-16 | Meanwell Clive (CEO) | Sale | 10,000 | 35.00 | 350,000 |
| 2016-05-16 | Meanwell Clive (CEO) | Option Ex | 10,000 | 28.60 | 286,000 |
| 2016-05-16 | Crouse William | Sale | 15,000 | 35.15 | 527,295 |
| 2016-05-16 | Crouse William | Option Ex | 15,000 | 18.60 | 279,000 |
| 2016-05-12 | Eshelman Fredric N | Buy | 300,000 | 33.68 | 10,104,000 |
| 2016-03-07 | Kessler Armin M | Sale | 8,100 | 34.82 | 282,042 |
| 2016-03-07 | Kessler Armin M | Option Ex | 15,000 | 18.60 | 279,000 |
| 2016-03-04 | O'connor William Bernard (Chief Financial Officer) | Sale | 8,617 | 34.51 | 297,329 |
| 2016-02-17 | Hugin Robert J | Option Ex | 15,000 | 18.60 | 279,000 |
| 2015-11-13 | Savage Robert G. | Sale | 5,000 | 39.34 | 196,700 |
| 2015-11-13 | Savage Robert G. | Option Ex | 5,000 | 18.60 | 93,000 |
| 2015-09-03 | Sblendorio Glenn (President & CFO) | Sale | 25,000 | 42.00 | 1,050,000 |
| 2015-09-03 | Sblendorio Glenn (President & CFO) | Option Ex | 25,000 | 22.04 | 551,000 |
| 2015-08-31 | O'connor William Bernard (SVP & Chief Acct. Officer) | Sale | 35,451 | 40.00 | 1,418,040 |
| 2015-08-31 | O'connor William Bernard (SVP & Chief Acct. Officer) | Option Ex | 35,451 | 14.91 | 528,680 |
| 2015-08-31 | Spigelman Melvin K | Sale | 20,000 | 40.50 | 810,000 |
| 2015-08-31 | Spigelman Melvin K | Option Ex | 20,000 | 20.87 | 417,400 |
| 2015-08-31 | Sblendorio Glenn (President & CFO) | Sale | 114,495 | 39.75 | 4,551,634 |
| 2015-08-31 | Sblendorio Glenn (President & CFO) | Option Ex | 114,495 | 21.80 | 2,496,334 |
| 2015-08-31 | Meanwell Clive (CEO) | Sale | 49,998 | 39.36 | 1,967,871 |
| 2015-08-31 | Meanwell Clive (CEO) | Option Ex | 49,998 | 18.27 | 913,463 |
| 2015-08-03 | Meanwell Clive (Chairman & CEO) | Sale | 16,667 | 30.96 | 515,960 |
| 2015-08-03 | Meanwell Clive (Chairman & CEO) | Option Ex | 16,667 | 18.27 | 304,506 |
| 2015-07-01 | Meanwell Clive (Chairman & CEO) | Sale | 16,667 | 28.39 | 473,242 |
| 2015-07-01 | Meanwell Clive (Chairman & CEO) | Option Ex | 16,667 | 18.27 | 304,506 |
| 2015-06-25 | Sblendorio Glenn (President & CFO) | Sale | 3,305 | 32.00 | 105,760 |
| 2015-06-08 | Shigeta Hiroaki | Sale | 7,500 | 28.99 | 217,425 |
| 2015-06-01 | Meanwell Clive (Chairman & CEO) | Sale | 16,667 | 28.11 | 468,442 |
| 2015-06-01 | Meanwell Clive (Chairman & CEO) | Option Ex | 16,667 | 18.27 | 304,506 |
| 2015-05-22 | Hugin Robert J | Option Ex | 15,000 | 21.45 | 321,750 |
| 2015-05-20 | Savage Robert G. | Sale | 15,000 | 26.78 | 401,640 |
| 2015-05-20 | Savage Robert G. | Option Ex | 15,000 | 21.45 | 321,750 |
| 2015-05-19 | Wyatt Elizabeth H S | Sale | 15,000 | 26.80 | 401,985 |
| 2015-05-19 | Wyatt Elizabeth H S | Option Ex | 15,000 | 21.45 | 321,750 |
| 2015-05-19 | Crouse William | Sale | 15,000 | 26.86 | 402,900 |
| 2015-05-19 | Crouse William | Option Ex | 15,000 | 21.45 | 321,750 |
| 2015-05-13 | Kessler Armin M | Sale | 12,475 | 25.87 | 322,728 |
| 2015-05-13 | Kessler Armin M | Option Ex | 15,000 | 21.45 | 321,750 |
| 2015-05-01 | Meanwell Clive (Chairman & CEO) | Sale | 16,667 | 26.52 | 442,025 |
| 2015-05-01 | Meanwell Clive (Chairman & CEO) | Option Ex | 16,667 | 18.27 | 304,506 |
| 2015-04-16 | O'connor William Bernard (SVP & Chief Acct. Officer) | Sale | 1,281 | 30.00 | 38,430 |
| 2015-04-01 | Meanwell Clive (Chairman & CEO) | Sale | 16,667 | 27.57 | 459,592 |
| 2015-04-01 | Meanwell Clive (Chairman & CEO) | Option Ex | 16,667 | 18.27 | 304,506 |
| 2015-03-30 | Wyatt Elizabeth H S | Sale | 20,000 | 28.08 | 561,540 |
| 2015-03-30 | Wyatt Elizabeth H S | Option Ex | 20,000 | 22.68 | 453,500 |
| 2015-03-23 | Sblendorio Glenn (President & CFO) | Sale | 34,773 | 30.78 | 1,070,312 |
| 2015-03-23 | Meanwell Clive (Chairman & CEO) | Sale | 16,667 | 30.62 | 510,393 |
| 2015-03-23 | Meanwell Clive (Chairman & CEO) | Option Ex | 16,667 | 18.27 | 304,506 |
| 2015-03-16 | Savage Robert G. | Sale | 7,500 | 28.98 | 217,365 |
| 2015-03-02 | O'connor William Bernard (SVP & Chief Acct. Officer) | Sale | 2,988 | 28.78 | 85,994 |
| 2014-03-03 | O'connor William Bernard (Sr VP & Chief Acct. Officer) | Sale | 2,968 | 30.31 | 89,960 |
| 2014-02-03 | Meanwell Clive (Chairman & CEO) | Sale | 10,000 | 34.29 | 342,920 |
| 2014-01-21 | Antinori Paul Michael (Sr. VP & General Counsel) | Sale | 37,883 | 37.99 | 1,439,213 |
| 2014-01-21 | Antinori Paul Michael (Sr. VP & General Counsel) | Option Ex | 37,500 | 13.19 | 494,737 |
| 2014-01-15 | O'connor William Bernard (Sr VP & Chief Acct. Officer) | Sale | 1,250 | 40.00 | 50,000 |
| 2014-01-15 | O'connor William Bernard (Sr VP & Chief Acct. Officer) | Option Ex | 1,250 | 22.04 | 27,550 |
| 2014-01-14 | O'connor William Bernard (Sr VP & Chief Acct. Officer) | Sale | 3,177 | 38.81 | 123,299 |
| 2014-01-14 | O'connor William Bernard (Sr VP & Chief Acct. Officer) | Option Ex | 3,177 | 12.38 | 39,331 |
| 2014-01-10 | O'connor William Bernard (Sr VP & Chief Acct. Officer) | Sale | 72,384 | 40.00 | 2,895,360 |
| 2014-01-10 | O'connor William Bernard (Sr VP & Chief Acct. Officer) | Option Ex | 72,384 | 17.46 | 1,264,041 |
| 2014-01-07 | Meanwell Clive (Chairman & CEO) | Sale | 24,627 | 38.13 | 938,953 |
| 2014-01-07 | Meanwell Clive (Chairman & CEO) | Option Ex | 24,627 | 28.02 | 690,048 |
| 2014-01-06 | Meanwell Clive (Chairman & CEO) | Sale | 3,302 | 38.13 | 125,905 |
| 2014-01-06 | Meanwell Clive (Chairman & CEO) | Option Ex | 3,302 | 28.02 | 92,522 |
| 2014-01-03 | Meanwell Clive (Chairman & CEO) | Sale | 47,516 | 38.20 | 1,814,873 |
| 2014-01-03 | Meanwell Clive (Chairman & CEO) | Option Ex | 47,516 | 28.02 | 1,331,398 |
| 2014-01-02 | Meanwell Clive (Chairman & CEO) | Sale | 34,555 | 37.98 | 1,312,260 |
| 2014-01-02 | Meanwell Clive (Chairman & CEO) | Option Ex | 24,555 | 28.02 | 688,031 |
| 2013-12-13 | Antinori Paul Michael (Sr. VP & General Counsel) | Sale | 9,600 | 36.91 | 354,335 |
| 2013-12-12 | Antinori Paul Michael (Sr. VP & General Counsel) | Sale | 10,000 | 37.01 | 370,110 |
| 2013-12-09 | Crouse William | Sale | 12,500 | 38.00 | 475,025 |
| 2013-12-09 | Crouse William | Option Ex | 12,500 | 32.30 | 403,749 |
| 2013-12-05 | Sblendorio Glenn (President & CFO) | Sale | 326 | 38.50 | 12,551 |
| 2013-12-05 | Sblendorio Glenn (President & CFO) | Option Ex | 326 | 20.11 | 6,555 |
| 2013-12-04 | Sblendorio Glenn (President & CFO) | Sale | 8,190 | 38.50 | 315,315 |
| 2013-12-04 | Sblendorio Glenn (President & CFO) | Option Ex | 8,190 | 20.11 | 164,700 |
| 2013-12-02 | Meanwell Clive (Chairman & CEO) | Sale | 10,000 | 36.58 | 365,760 |
| 2013-11-26 | Meanwell Clive (Chairman & CEO) | Sale | 25,136 | 36.66 | 921,485 |
| 2013-11-26 | Meanwell Clive (Chairman & CEO) | Option Ex | 25,136 | 28.01 | 704,059 |
| 2013-11-25 | Shigeta Hiroaki | Sale | 17,039 | 37.19 | 633,680 |
| 2013-11-25 | Shigeta Hiroaki | Option Ex | 17,039 | 21.14 | 360,204 |
| 2013-11-25 | Meanwell Clive (Chairman & CEO) | Sale | 109,864 | 36.71 | 4,033,107 |
| 2013-11-25 | Meanwell Clive (Chairman & CEO) | Option Ex | 99,864 | 28.01 | 2,797,190 |
| 2013-11-18 | Sblendorio Glenn (President & CFO) | Sale | 16,484 | 38.50 | 634,634 |
Insider trading activities including stock purchases, stock sales, and option exercises of MDCO listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Medicines Co /de (symbol MDCO, CIK number 1113481) see the Securities and Exchange Commission (SEC) website.