1. Corporate Officers - G
2. Greene Barry E

Insider Trading History of Greene Barry E

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) of Greene Barry E since 2006. This trader's CIK number is 1291963. At the time of last reporting, Greene Barry E was the Director of Karyopharm Therapeutics Inc.. (stock ticker symbol KPTI). Also see all insider trading activities at Karyopharm Therapeutics Inc..

Note that in the past Greene Barry E also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Sage Therapeutics, Inc. (SAGE) by Greene Barry E

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	SAGE	32,440	$1,515,690	0	$0	0	$0

Yearly summary of insider trading at Karyopharm Therapeutics Inc. (KPTI) by Greene Barry E

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	KPTI	0	$0	0	$0	7,576	$11,250
2020	KPTI	0	$0	0	$0	3,030	$99
2015	KPTI	3,000	$87,939	0	$0	0	$0

Yearly summary of insider trading at Alnylam Pharmaceuticals, Inc. (ALNY) by Greene Barry E

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	ALNY	0	$0	89,060	$12,400,134	93,991	$1,172,269
2019	ALNY	0	$0	58,913	$5,301,580	58,913	$967,940
2018	ALNY	0	$0	38,460	$5,503,049	0	$0
2017	ALNY	0	$0	162,131	$18,346,000	173,975	$4,385,268
2016	ALNY	0	$0	0	$0	16,540	$134,304
2015	ALNY	0	$0	67,379	$8,422,375	94,351	$1,397,289
2014	ALNY	0	$0	55,500	$5,250,104	64,800	$445,684
2013	ALNY	0	$0	70,880	$1,872,382	82,080	$143,271
2012	ALNY	2,427	$24,986	0	$0	0	$0
2011	ALNY	2,145	$14,984	0	$0	0	$0
2008	ALNY	0	$0	35,440	$1,202,372	30,889	$29,344
2007	ALNY	0	$0	37,500	$1,162,692	0	$0
2006	ALNY	0	$0	12,500	$258,875	0	$0

Yearly summary of insider trading at Acorda Therapeutics Inc (ACOR) by Greene Barry E

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2018	ACOR	0	$0	0	$0	10,000	$201,600
2017	ACOR	0	$0	13,740	$290,188	13,740	$246,099

Insider trading activities at 4 companies by Greene Barry E:

1. Sage Therapeutics, Inc. (SAGE)

2. Karyopharm Therapeutics Inc. (KPTI)

3. Alnylam Pharmaceuticals, Inc. (ALNY)

4. Acorda Therapeutics Inc (ACOR)

Table 1. Insider trading of Sage Therapeutics, Inc. (SAGE) by Greene Barry E

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-08-05	SAGE	Buy	23,640	43.15	1,020,066
2021-06-16	SAGE	Buy	8,800	56.32	495,624

Table 2. Insider trading of Karyopharm Therapeutics Inc. (KPTI) by Greene Barry E

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-08-11	KPTI	Option Ex	7,576	1.49	11,250
2020-03-13	KPTI	Option Ex	3,030	.03	99
2015-04-02	KPTI	Buy	3,000	29.31	87,939

Table 3. Insider trading of Alnylam Pharmaceuticals, Inc. (ALNY) by Greene Barry E

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-09-09	ALNY	Option Ex	44,530	9.14	407,004
2020-09-09	ALNY	Sale	44,530	123.48	5,498,430
2020-08-10	ALNY	Option Ex	4,931	72.66	358,261
2020-07-07	ALNY	Option Ex	22,265	9.14	203,502
2020-07-07	ALNY	Sale	22,265	159.99	3,562,177
2020-05-06	ALNY	Option Ex	22,265	9.14	203,502
2020-05-06	ALNY	Sale	22,265	149.99	3,339,527
2019-10-22	ALNY	Option Ex	58,913	16.43	967,940
2019-10-22	ALNY	Sale	58,913	89.99	5,301,580
2018-03-14	ALNY	Sale	38,460	143.09	5,503,049
2017-10-02	ALNY	Option Ex	85,316	21.35	1,821,496
2017-10-02	ALNY	Sale	85,316	125.00	10,664,500
2017-09-20	ALNY	Option Ex	76,815	31.39	2,411,222
2017-09-21	ALNY	Option Ex	11,844	12.88	152,550
2017-09-20	ALNY	Sale	76,815	100.00	7,681,500
2016-03-24	ALNY	Option Ex	16,540	8.12	134,304
2015-08-04	ALNY	Option Ex	26,972	19.03	513,277
2015-05-26	ALNY	Option Ex	67,379	13.12	884,012
2015-05-26	ALNY	Sale	67,379	125.00	8,422,375
2014-12-19	ALNY	Sale	11,200	100.00	1,120,000
2014-12-22	ALNY	Option Ex	1,000	13.12	13,120
2014-11-17	ALNY	Sale	33,200	90.97	3,020,104
2014-11-17	ALNY	Option Ex	33,200	6.78	225,096
2014-11-11	ALNY	Sale	11,100	100.00	1,110,000
2014-11-11	ALNY	Option Ex	11,100	6.78	75,258
2014-02-03	ALNY	Option Ex	19,500	6.78	132,210
2013-12-17	ALNY	Option Ex	11,200	6.78	75,936
2013-05-28	ALNY	Option Ex	22,822	.95	21,680
2013-05-28	ALNY	Sale	22,822	30.00	684,660
2013-03-14	ALNY	Sale	24,058	25.00	601,450
2013-03-14	ALNY	Option Ex	24,058	.95	22,855
2013-03-08	ALNY	Option Ex	24,000	.95	22,800
2013-03-08	ALNY	Sale	24,000	24.43	586,272
2012-02-21	ALNY	Buy	1,860	10.75	19,995
2012-01-09	ALNY	Buy	567	8.80	4,991
2011-12-12	ALNY	Buy	699	7.15	4,995
2011-11-14	ALNY	Buy	704	7.09	4,994
2011-10-11	ALNY	Buy	742	6.73	4,995
2008-08-13	ALNY	Option Ex	30,889	.95	29,344
2008-08-13	ALNY	Sale	35,440	33.93	1,202,372
2007-10-24	ALNY	Sale	21,700	30.79	668,186
2007-10-24	ALNY	Sale	10,580	31.13	329,387
2007-10-24	ALNY	Sale	5,220	31.63	165,119
2006-10-31	ALNY	Sale	12,500	20.71	258,875

Table 4. Insider trading of Acorda Therapeutics Inc (ACOR) by Greene Barry E

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2018-05-21	ACOR	Option Ex	10,000	20.16	201,600
2017-08-01	ACOR	Sale	10,000	21.57	215,700
2017-08-01	ACOR	Option Ex	10,000	18.21	182,100
2017-02-09	ACOR	Sale	723	22.65	16,375
2017-02-09	ACOR	Option Ex	723	22.13	15,999
2017-01-03	ACOR	Option Ex	3,017	15.91	48,000
2017-01-03	ACOR	Sale	3,017	19.26	58,113

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Greene Barry E (Director of Karyopharm Therapeutics Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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