Insider Trading activities at Karyopharm Therapeutics Inc. (KPTI)

Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Karyopharm Therapeutics Inc. (KPTI) since 2015 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Karyopharm Therapeutics Inc.. Table 2 shows the detailed insider transactions. This company's CIK number is 1503802.

Total stock buying since 2015: $2,063,182.
Total stock sales since 2015: $66,196,049.
Total stock option exercises since 2015: $5,268,800.

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Table 1. Yearly summary of insider stock purchases, sales, and option exercises at *Karyopharm Therapeutics Inc.* (*KPTI*).
	Insider Buying		Insider Sales		Option Exercises
Year	Shares	Value	Shares	Value	Shares	Value
2025	0	$0	41,047	$177,872	0	$0
2024	0	$0	2,025,843	$2,009,785	0	$0
2023	0	$0	161,745	$432,827	0	$0
2022	0	$0	658,997	$4,646,033	7,576	$11,250
2021	27,250	$231,276	86,264	$1,277,051	184,025	$0
2020	0	$0	643,696	$11,943,521	708,450	$3,557,164
2019	0	$0	1,859,674	$10,981,244	225,407	$997,830
2018	0	$0	1,432,153	$26,187,121	505,000	$578,316
2017	0	$0	88,458	$904,593	92,000	$123,059
2016	0	$0	462,073	$4,110,867	45,000	$0
2015	56,454	$1,831,906	115,000	$3,525,135	10,738	$1,181

Table 2. Monthly summary of insider trading at *Karyopharm Therapeutics Inc.* (*KPTI*).
Trading Period	Insider Buying		Insider Sales		Option Exercises
year-month	Shares	Value	Shares	Value	Shares	Value
2025-09	0	$0	12	$81	0	$0
2025-07	0	$0	429	$1,786	0	$0
2025-05	0	$0	236	$1,680	0	$0
2025-04	0	$0	664	$3,501	0	$0
2025-03	0	$0	25,638	$161,260	0	$0
2025-02	0	$0	10,013	$6,389	0	$0
2025-01	0	$0	4,055	$3,175	0	$0
2024-11	0	$0	3,675	$3,347	0	$0
2024-10	0	$0	3,607	$3,170	0	$0
2024-09	0	$0	20,044	$14,471	0	$0
2024-08	0	$0	3,608	$3,355	0	$0
2024-07	0	$0	6,499	$6,132	0	$0
2024-06	0	$0	1,524,072	$1,475,001	0	$0
2024-05	0	$0	207,970	$199,031	0	$0
2024-04	0	$0	10,352	$12,539	0	$0
2024-03	0	$0	46,345	$55,611	0	$0
2024-02	0	$0	195,557	$233,755	0	$0
2024-01	0	$0	4,114	$3,373	0	$0
2023-12	0	$0	3,622	$2,861	0	$0
2023-11	0	$0	3,606	$3,317	0	$0
2023-10	0	$0	3,589	$4,558	0	$0
2023-09	0	$0	21,838	$29,043	0	$0
2023-08	0	$0	3,722	$6,401	0	$0
2023-07	0	$0	6,383	$10,921	0	$0

Table 3. Detailed insider trading at *Karyopharm Therapeutics Inc.* (*KPTI*)
Trade Date	Insider Name	Trade Type	Shares	Price ($)	Value ($)
2025-09-03	Abate Kristin (Chief Accounting Officer)	Sale	12	6.78	81
2025-07-29	Poulton Stuart (EVP, Chief Development Officer)	Sale	191	4.37	834
2025-07-22	Abate Kristin (Chief Accounting Officer)	Sale	238	4.00	952
2025-05-06	Paulson Richard A. (President and CEO)	Sale	236	7.12	1,680
2025-04-23	Rangwala Reshma (EVP & Chief Medical Officer)	Sale	419	6.17	2,585
2025-04-04	Paulson Richard A. (President and CEO)	Sale	245	3.74	916
2025-03-04	Abate Kristin (Chief Accounting Officer)	Sale	571	6.29	3,591
2025-03-04	Poulton Stuart (EVP, Chief Development Officer)	Sale	3,548	6.29	22,316
2025-03-04	Cheng Sohanya Roshan (EVP & Chief Commercial Officer)	Sale	3,445	6.29	21,669
2025-03-04	Mano Michael (SVP, General Counsel&Secretary)	Sale	2,793	6.29	17,567
2025-03-04	Rangwala Reshma (EVP & Chief Medical Officer)	Sale	3,587	6.29	22,562
2025-03-04	Paulson Richard A. (President and CEO)	Sale	11,694	6.29	73,555
2025-02-18	Poulton Stuart (EVP, Chief Development Officer)	Sale	5,914	.63	3,725
2025-02-04	Paulson Richard A. (President and CEO)	Sale	4,099	.65	2,664
2025-01-06	Paulson Richard A. (President and CEO)	Sale	4,055	.78	3,175
2024-11-05	Paulson Richard A. (President and CEO)	Sale	3,675	.91	3,347
2024-10-04	Paulson Richard A. (President and CEO)	Sale	3,607	.88	3,170
2024-09-04	Cheng Sohanya Roshan (EVP & Chief Commercial Officer)	Sale	5,356	.72	3,867
2024-09-04	Mano Michael (SVP, General Counsel&Secretary)	Sale	3,971	.72	2,867
2024-09-04	Paulson Richard A. (President and CEO)	Sale	3,667	.72	2,647
2024-09-04	Mason Michael (EVP, CFO & Treasurer)	Sale	7,050	.72	5,090
2024-08-06	Paulson Richard A. (President and CEO)	Sale	3,608	.93	3,355
2024-07-30	Poulton Stuart (EVP, Chief Development Officer)	Sale	2,883	1.06	3,055
2024-07-05	Paulson Richard A. (President and CEO)	Sale	3,616	.85	3,077
2024-06-07	Pakianathan Deepika	Sale	231,548	.95	220,202
2024-06-06	Pakianathan Deepika	Sale	118,452	.98	116,438
2024-06-05	Pakianathan Deepika	Sale	468,044	.96	448,386
2024-06-04	Paulson Richard A. (President and CEO)	Sale	3,592	.99	3,556
2024-06-04	Mason Michael (EVP, CFO & Treasurer)	Sale	652	.99	645
2024-06-04	Pakianathan Deepika	Sale	341,040	.95	324,670
2024-06-03	Pakianathan Deepika	Sale	360,744	1.00	361,104
2024-05-31	Pakianathan Deepika	Sale	204,394	.95	194,991
2024-05-06	Paulson Richard A. (President and CEO)	Sale	3,576	1.13	4,040
2024-04-22	Rangwala Reshma (EVP & Chief Medical Officer)	Sale	6,789	1.17	7,943
2024-04-04	Paulson Richard A. (President and CEO)	Sale	3,563	1.29	4,596
2024-03-01	Poulton Stuart (EVP, Chief Development Officer)	Sale	6,155	1.20	7,386
2024-03-01	Cheng Sohanya Roshan (EVP & Chief Commercial Officer)	Sale	5,109	1.20	6,130
2024-03-01	Mano Michael (SVP, General Counsel&Secretary)	Sale	3,576	1.20	4,291
2024-03-01	Rangwala Reshma (EVP & Chief Medical Officer)	Sale	5,969	1.20	7,162
2024-03-01	Paulson Richard A. (President and CEO)	Sale	19,374	1.20	23,248
2024-03-01	Mason Michael (EVP, CFO & Treasurer)	Sale	6,162	1.20	7,394
2024-02-29	Poulton Stuart (EVP, Chief Development Officer)	Sale	16,311	1.17	19,083
2024-02-29	Cheng Sohanya Roshan (EVP & Chief Commercial Officer)	Sale	21,840	1.17	25,552
2024-02-29	Mano Michael (SVP, General Counsel&Secretary)	Sale	16,973	1.17	19,858
2024-02-29	Rangwala Reshma (EVP & Chief Medical Officer)	Sale	15,667	1.17	18,330
2024-02-29	Paulson Richard A. (President and CEO)	Sale	80,470	1.17	94,149
2024-02-29	Mason Michael (EVP, CFO & Treasurer)	Sale	27,687	1.17	32,393
2024-02-27	Mason Michael (EVP, CFO & Treasurer)	Sale	2,545	1.32	3,369
2024-02-15	Poulton Stuart (EVP, Chief Development Officer)	Sale	5,847	1.36	7,981
2024-02-06	Paulson Richard A. (President and CEO)	Sale	4,012	1.59	6,367
2024-02-06	Mason Michael (EVP, CFO & Treasurer)	Sale	4,205	1.59	6,673
2024-01-04	Paulson Richard A. (President and CEO)	Sale	4,114	.82	3,373
2023-12-04	Paulson Richard A. (President and CEO)	Sale	3,622	.79	2,861
2023-11-06	Paulson Richard A. (President and CEO)	Sale	3,606	.92	3,317
2023-10-04	Paulson Richard A. (President and CEO)	Sale	3,589	1.27	4,558
2023-09-05	Paulson Richard A. (President and CEO)	Sale	3,622	1.32	4,799
2023-09-01	Cheng Sohanya Roshan (EVP & Chief Commercial Officer)	Sale	7,415	1.33	9,869
2023-09-01	Mano Michael (SVP, General Counsel&Secretary)	Sale	3,888	1.33	5,174
2023-09-01	Mason Michael (EVP, CFO & Treasurer)	Sale	6,913	1.33	9,201
2023-08-07	Paulson Richard A. (President and CEO)	Sale	3,722	1.72	6,401
2023-07-28	Poulton Stuart (EVP, Chief Development Officer)	Sale	2,845	1.70	4,836
2023-07-05	Paulson Richard A. (President and CEO)	Sale	3,538	1.72	6,085
2023-06-05	Paulson Richard A. (President and CEO)	Sale	3,536	2.24	7,920
2023-06-02	Mason Michael (EVP, CFO & Treasurer)	Sale	631	2.22	1,400
2023-05-04	Paulson Richard A. (President and CEO)	Sale	3,805	3.35	12,754
2023-04-20	Rangwala Reshma (EVP & Chief Medical Officer)	Sale	6,770	4.04	27,337
2023-04-04	Paulson Richard A. (President and CEO)	Sale	3,497	3.97	13,883
2023-03-06	Paulson Richard A. (President and CEO)	Sale	3,506	3.16	11,078
2023-03-01	Cheng Sohanya Roshan (EVP & Chief Commercial Officer)	Sale	11,239	3.03	34,042
2023-03-01	Mano Michael (SVP, General Counsel&Secretary)	Sale	6,878	3.03	20,833
2023-03-01	Paulson Richard A. (President and CEO)	Sale	33,033	3.03	100,056
2023-03-01	Mitchener Stephen (SVP, Chief Business Officer)	Sale	6,357	3.03	19,255
2023-03-01	Mason Michael (EVP, CFO & Treasurer)	Sale	11,205	3.03	33,939
2023-02-27	Mason Michael (EVP, CFO & Treasurer)	Sale	2,802	3.04	8,509
2023-02-15	Poulton Stuart (EVP, Chief Development Officer)	Sale	5,869	3.19	18,739
2023-02-06	Paulson Richard A. (President and CEO)	Sale	3,950	3.40	13,430
2023-02-06	Mason Michael (EVP, CFO & Treasurer)	Sale	4,141	3.40	14,079
2023-01-04	Paulson Richard A. (President and CEO)	Sale	7,844	3.27	25,648
2022-11-04	Paulson Richard A. (President and CEO)	Sale	3,493	4.54	15,858
2022-09-08	Paulson Richard A. (President and CEO)	Sale	3,479	5.24	18,240
2022-08-11	Greene Barry E (Director)	Option Ex	7,576	1.49	11,250
2022-08-04	Paulson Richard A. (President and CEO)	Sale	2,314	4.48	10,366
2022-07-08	Paulson Richard A. (President and CEO)	Sale	2,115	5.18	10,947
2022-06-13	Cheng Sohanya Roshan (Chief Commercial Officer)	Sale	1,551	5.27	8,178
2022-06-10	Pakianathan Deepika (Director)	Sale	1,307	6.00	7,844
2022-06-09	Pakianathan Deepika (Director)	Sale	211,500	6.18	1,307,070
2022-06-08	Pakianathan Deepika (Director)	Sale	325,977	6.50	2,119,828
2022-06-07	Paulson Richard A. (President and CEO)	Sale	2,542	5.76	14,641
2022-06-03	Mason Michael (EVP, CFO, Treasurer)	Sale	601	6.05	3,638
2022-02-28	Frenkel Ran (EVP, Chief Dev. Officer)	Sale	1,663	10.24	17,025
2022-02-28	Shacham Sharon (Chief Scientific Officer)	Sale	12,452	10.24	127,483
2022-02-28	Mason Michael (EVP, CFO & Treasurer)	Sale	2,398	10.24	24,550
2022-02-28	Kauffman Michael (Director)	Sale	12,452	10.24	127,483
2022-02-17	Shah Jatin (EVP, Chief Medical Officer)	Sale	1,306	12.12	15,832
2022-02-17	Frenkel Ran (EVP, Chief Dev. Officer)	Sale	2,929	12.12	35,508
2022-02-17	Shacham Sharon (Chief Scientific Officer)	Sale	18,167	12.12	220,238
2022-02-17	Kauffman Michael (Director)	Sale	18,167	12.12	220,238
2022-02-07	Shah Jatin (EVP, Chief Medical Officer)	Sale	1,704	9.86	16,804
2022-02-07	Frenkel Ran (EVP, Chief Dev. Officer)	Sale	1,991	9.86	19,635
2022-02-07	Shacham Sharon (Chief Scientific Officer)	Sale	13,471	9.86	132,851
2022-02-07	Mason Michael (EVP, CFO & Treasurer)	Sale	3,947	9.86	38,925
2022-02-07	Kauffman Michael (Director)	Sale	13,471	9.86	132,851
2021-12-02	Mitchener Stephen (SVP, Chief Business Officer)	Sale	499	6.69	3,338
2021-06-02	Mitchener Stephen (SVP, Chief Business Officer)	Sale	528	9.29	4,905
2021-05-07	Shah Jatin (EVP, Chief Medical Officer)	Buy	23,250	8.60	199,996
2021-05-06	Bohlin Garen G (Director)	Buy	4,000	7.82	31,280
2021-03-18	Shacham Sharon (President & CSO)	Sale	4,000	12.39	49,552
2021-03-18	Kauffman Michael (Chief Executive Officer)	Sale	4,000	12.39	49,552
2021-02-18	Shah Jatin (EVP, Chief Medical Officer)	Sale	1,186	14.83	17,589
2021-02-18	Frenkel Ran (EVP, Chief Dev. Officer)	Sale	2,887	14.83	42,817
2021-02-18	Shacham Sharon (President & CSO)	Sale	18,990	14.83	281,640
2021-02-18	Kauffman Michael (Chief Executive Officer)	Sale	18,990	14.83	281,640
2021-02-15	Shah Jatin (EVP, Chief Medical Officer)	Option Ex	4,850	.00	0
2021-02-15	Frenkel Ran (EVP, Chief Dev. Officer)	Option Ex	9,675	.00	0
2021-02-15	Shacham Sharon (President & CSO)	Option Ex	43,600	.00	0
2021-02-15	Kauffman Michael (Chief Executive Officer)	Option Ex	43,600	.00	0
2021-02-11	Shah Jatin (EVP, Chief Medical Officer)	Sale	1,748	15.52	27,127
2021-02-11	Frenkel Ran (EVP, Chief Dev. Officer)	Sale	2,046	15.52	31,751
2021-02-11	Shacham Sharon (President & CSO)	Sale	13,243	15.52	205,518
2021-02-11	Mason Michael (SVP, CFO & Treasurer)	Sale	2,858	15.52	44,353
2021-02-11	Lewis Tanya (EVP, Chief Reg. Affairs)	Sale	2,046	15.52	31,751
2021-02-11	Kauffman Michael (Chief Executive Officer)	Sale	13,243	15.52	205,518
2021-02-05	Shah Jatin (EVP, Chief Medical Officer)	Option Ex	5,650	.00	0
2021-02-05	Frenkel Ran (EVP, Chief Dev. Officer)	Option Ex	5,650	.00	0
2021-02-05	Shacham Sharon (President & CSO)	Option Ex	28,600	.00	0
2021-02-05	Mason Michael (SVP, CFO & Treasurer)	Option Ex	8,150	.00	0
2021-02-05	Lewis Tanya (EVP, Chief Reg. Affairs)	Option Ex	5,650	.00	0
2021-02-05	Kauffman Michael (Chief Executive Officer)	Option Ex	28,600	.00	0
2020-12-18	Mirza Mansoor Raza (Director)	Sale	5,000	18.00	90,000
2020-12-18	Mirza Mansoor Raza (Director)	Option Ex	5,000	5.43	27,150
2020-12-07	Mirza Mansoor Raza (Director)	Sale	20,000	16.07	321,380
2020-12-07	Mirza Mansoor Raza (Director)	Option Ex	20,000	5.43	108,600
2020-12-01	Primiano Christopher Brett (EVP, CBO, GC & Secretary)	Sale	137,061	17.50	2,399,252
2020-12-01	Primiano Christopher Brett (EVP, CBO, GC & Secretary)	Option Ex	137,061	10.42	1,428,175
2020-11-02	Primiano Christopher Brett (EVP, CBO, GC & Secretary)	Sale	772	14.92	11,518
2020-10-30	Lewis Tanya (EVP,Chief Reg.&Quality Officer)	Sale	226	15.58	3,521
2020-10-28	Lewis Tanya (EVP,Chief Reg.&Quality Officer)	Option Ex	765	.00	0
2020-10-13	Primiano Christopher Brett (EVP, CBO, GC & Secretary)	Sale	39,271	17.02	668,588
2020-10-13	Primiano Christopher Brett (EVP, CBO, GC & Secretary)	Option Ex	39,271	9.80	384,855
2020-10-12	Shacham Sharon (President & CSO)	Sale	7,500	14.89	111,682
2020-10-12	Shacham Sharon (President & CSO)	Option Ex	7,500	.03	247
2020-10-12	Kauffman Michael (Chief Executive Officer)	Sale	7,500	14.89	111,682
2020-10-12	Kauffman Michael (Chief Executive Officer)	Option Ex	7,500	.03	247
2020-09-08	Primiano Christopher Brett (EVP, CBO, GC & Secretary)	Sale	10,054	14.98	150,608
2020-09-08	Primiano Christopher Brett (EVP, CBO, GC & Secretary)	Option Ex	10,054	6.54	65,753
2020-08-17	Shacham Sharon (President & CSO)	Sale	1,477	15.00	22,155
2020-08-17	Shacham Sharon (President & CSO)	Option Ex	1,477	.03	48
2020-08-17	Kauffman Michael (Chief Executive Officer)	Sale	1,477	15.00	22,155
2020-08-17	Kauffman Michael (Chief Executive Officer)	Option Ex	1,477	.03	48
2020-07-15	Shah Jatin (EVP, Chief Medical Officer)	Sale	589	19.46	11,461

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Insider trading activities including stock purchases, stock sales, and option exercises of KPTI listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Karyopharm Therapeutics Inc. (symbol KPTI, CIK number 1503802) see the Securities and Exchange Commission (SEC) website.

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