Insider Trading activities of Ionis Pharmaceuticals Inc insiders. , Part 2

Monthly summaries of insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Ionis Pharmaceuticals Inc since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Ionis Pharmaceuticals Inc since year 2005. (See page 1 of this report.) Table 2 shows the detailed insider transactions of Ionis Pharmaceuticals Inc since 2005. The reporting company's ticker symbol is IONS. The reporting company's CIK number is 874015.
The total value of stock buying since 2005 is $90,940.
The total value of stock sales since 2005 is $150,519,131.
The total value of stock option exercises since 2005 is $48,346,011.



Table 2. Detailed insider stock purchases, sales, and option exercises of Ionis Pharmaceuticals Inc insiders (IONS) , Part 2
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2016-12-05 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 350 10.82 3,787
2016-12-05 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 46.05 115,125
2016-12-05 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-12-01 Parshall B Lynne (COO) Sale 12,500 42.33 529,125
2016-12-01 Parshall B Lynne (COO) Option Ex 12,500 14.69 183,625
2016-11-14 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.00 45,000
2016-11-14 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-11-14 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 47.50 118,750
2016-11-14 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-11 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 41.00 102,500
2016-11-11 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-10 Crooke Stanley T (Chairman and CEO) Sale 11,000 41.23 453,475
2016-11-10 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 8.77 96,470
2016-11-09 Hougen Elizabeth L (SVP, Finance & CFO) Sale 2,500 38.49 96,225
2016-11-09 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 2,500 11.27 28,175
2016-11-09 Bennett C Frank (SVP, Antisense Research) Sale 22,805 36.31 828,049
2016-11-09 Bennett C Frank (SVP, Antisense Research) Option Ex 22,805 11.27 257,012
2016-11-09 Crooke Stanley T (Chairman and CEO) Sale 22,000 36.50 803,000
2016-11-09 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 9.68 213,004
2016-11-07 Bennett C Frank (SVP, Antisense Research) Sale 5,000 34.00 170,000
2016-11-07 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 11.27 56,350
2016-10-05 Crooke Stanley T (Chairman and CEO) Sale 11,000 36.61 402,710
2016-10-05 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.29 113,189
2016-09-27 Crooke Stanley T (Chairman and CEO) Sale 22,000 36.03 792,769
2016-09-27 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 10.29 226,379
2016-09-21 Crooke Stanley T (Chairman and CEO) Sale 22,000 35.50 781,000
2016-09-21 Crooke Stanley T (Chairman and CEO) Option Ex 22,000 10.29 226,379
2016-09-01 Parshall B Lynne (COO) Sale 12,500 29.93 374,162
2016-09-01 Parshall B Lynne (COO) Option Ex 12,500 10.97 137,125
2016-07-02 Klein Joseph Iii (Director) Option Ex 312 .00 0
2016-07-02 Muto Frederick T (Director) Option Ex 312 .00 0
2016-07-02 Berthelsen Spencer R (Director) Option Ex 312 .00 0
2016-07-02 Wender Joseph H (Director) Option Ex 312 .00 0
2016-07-01 Castleman Breaux (Director) Option Ex 2,740 .00 0
2016-07-01 Loscalzo Joseph (Director) Option Ex 1,334 .00 0
2016-07-01 Klein Joseph Iii (Director) Option Ex 1,803 .00 0
2016-07-01 Muto Frederick T (Director) Option Ex 1,803 .00 0
2016-07-01 Berthelsen Spencer R (Director) Option Ex 1,803 .00 0
2016-07-01 Wender Joseph H (Director) Option Ex 1,803 .00 0
2016-05-31 Muto Frederick T (Director) Sale 12,500 22.31 278,900
2016-05-31 Muto Frederick T (Director) Option Ex 12,500 5.93 74,125
2016-04-06 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.00 45,000
2016-04-06 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-04-06 Crooke Stanley T (Chairman and CEO) Sale 11,000 46.12 507,375
2016-04-06 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.29 113,189
2016-03-31 Crooke Stanley T (Chairman and CEO) Sale 11,000 40.73 448,085
2016-03-31 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 10.02 110,242
2016-03-23 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 45.40 45,400
2016-03-23 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 10.82 10,820
2016-02-19 Berthelsen Spencer R (Director) Option Ex 12,500 5.93 74,125
2016-02-03 Loscalzo Joseph (Director) Option Ex 938 .00 0
2016-01-19 Boyce Sarah (Chief Business Officer) Sale 872 41.46 36,150
2016-01-19 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,871 41.46 77,571
2016-01-19 Monia Brett P (SVP, Antisense Drug Discovery) Sale 2,208 41.46 91,545
2016-01-19 Geary Richard S (SVP, Development) Sale 2,162 41.46 89,634
2016-01-19 Hougen Elizabeth L (SVP, Finance & CFO) Sale 1,899 41.46 78,740
2016-01-19 Bennett C Frank (SVP, Antisense Research) Sale 2,110 41.46 87,474
2016-01-19 Parshall B Lynne (COO & Secretary) Sale 5,192 41.46 215,260
2016-01-19 Crooke Stanley T (Chairman and CEO) Sale 13,401 41.46 555,605
2016-01-15 Boyce Sarah (Chief Business Officer) Option Ex 2,188 .00 0
2016-01-15 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 4,693 .00 0
2016-01-15 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 5,543 .00 0
2016-01-15 Geary Richard S (SVP, Development) Option Ex 5,427 .00 0
2016-01-15 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 4,762 .00 0
2016-01-15 Bennett C Frank (SVP, Antisense Research) Option Ex 5,295 .00 0
2016-01-15 Parshall B Lynne (COO & Secretary) Option Ex 13,267 .00 0
2016-01-15 Crooke Stanley T (Chairman and CEO) Option Ex 24,661 .00 0
2016-01-05 Crooke Stanley T (Chairman and CEO) Sale 5,500 62.10 341,550
2016-01-05 Crooke Stanley T (Chairman and CEO) Option Ex 5,500 9.76 53,652
2016-01-04 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 61.10 61,100
2016-01-04 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 9.04 9,035
2016-01-04 Monia Brett P (SVP, Antisense Drug Discovery) Sale 127 61.00 7,747
2016-01-04 Parshall B Lynne (COO & Secretary) Sale 809 61.05 49,389
2016-01-04 Parshall B Lynne (COO & Secretary) Option Ex 809 14.69 11,884
2016-01-04 Crooke Stanley T (Chairman and CEO) Sale 11,000 61.05 671,550
2016-01-04 Crooke Stanley T (Chairman and CEO) Option Ex 11,000 9.76 107,305
2015-12-16 Bennett C Frank (SVP, Antisense Research) Sale 3,909 58.85 230,044
2015-12-16 Bennett C Frank (SVP, Antisense Research) Option Ex 3,909 14.47 56,563
2015-12-15 Bennett C Frank (SVP, Antisense Research) Sale 4,000 56.00 224,000
2015-12-15 Bennett C Frank (SVP, Antisense Research) Option Ex 4,000 14.47 57,880
2015-12-01 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 61.50 61,500
2015-12-01 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 7.25 7,250
2015-11-11 Klein Joseph Iii (Director) Sale 6,875 64.18 441,237
2015-11-11 Klein Joseph Iii (Director) Option Ex 6,875 11.12 76,450
2015-11-10 Bennett C Frank (SVP, Antisense Research) Sale 5,000 64.00 320,000
2015-11-10 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 14.47 72,350
2015-11-06 Bennett C Frank (SVP, Antisense Research) Sale 5,000 56.00 280,000
2015-11-06 Bennett C Frank (SVP, Antisense Research) Option Ex 5,000 14.47 72,350
2015-11-03 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 1,000 51.95 51,950
2015-11-03 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 1,000 7.25 7,250
2015-10-23 Crooke Stanley T (Chairman and CEO) Sale 27,500 44.57 1,225,675
2015-10-23 Crooke Stanley T (Chairman and CEO) Option Ex 27,500 10.06 276,595
2015-10-21 Crooke Stanley T (Chairman and CEO) Sale 16,500 43.00 709,500
2015-10-21 Crooke Stanley T (Chairman and CEO) Option Ex 16,500 10.59 174,685
2015-10-02 Parshall B Lynne (COO & Secretary) Sale 5,436 41.25 224,218
2015-10-02 Parshall B Lynne (COO & Secretary) Option Ex 5,436 14.69 79,854
2015-10-01 Parshall B Lynne (COO & Secretary) Sale 7,000 40.13 280,882
2015-10-01 Parshall B Lynne (COO & Secretary) Option Ex 7,000 10.97 76,790
2015-07-06 Parshall B Lynne (COO & Secretary) Sale 6,218 57.01 354,469
2015-07-06 Parshall B Lynne (COO & Secretary) Option Ex 6,218 8.77 54,531
2015-07-06 Crooke Stanley T (Chairman and CEO) Sale 6,175 57.01 352,018
2015-07-06 Crooke Stanley T (Chairman and CEO) Option Ex 6,175 10.24 63,262
2015-07-02 Monia Brett P (SVP, Antisense Drug Discovery) Sale 198 56.30 11,147
2015-07-02 Klein Joseph Iii (Director) Option Ex 312 .00 0
2015-07-02 Muto Frederick T (Director) Option Ex 312 .00 0
2015-07-02 Berthelsen Spencer R (Director) Option Ex 312 .00 0
2015-07-02 Wender Joseph H (Director) Option Ex 312 .00 0
2015-07-01 Castleman Breaux (Director) Option Ex 2,074 .00 0
2015-07-01 Loscalzo Joseph (Director) Option Ex 667 .00 0
2015-07-01 Klein Joseph Iii (Director) Option Ex 1,136 .00 0
2015-07-01 Muto Frederick T (Director) Option Ex 1,136 .00 0
2015-07-01 Berthelsen Spencer R (Director) Option Ex 1,136 .00 0
2015-07-01 Parshall B Lynne (COO & Secretary) Sale 6,218 57.56 357,914
2015-07-01 Parshall B Lynne (COO & Secretary) Option Ex 6,218 10.29 63,983
2015-07-01 Wender Joseph H (Director) Option Ex 1,136 .00 0
2015-07-01 Crooke Stanley T (Chairman and CEO) Sale 6,175 57.56 355,439
2015-07-01 Crooke Stanley T (Chairman and CEO) Option Ex 6,175 10.24 63,262
2015-06-08 Monia Brett P (SVP, Antisense Drug Discovery) Sale 7,600 66.22 503,279
2015-06-08 Monia Brett P (SVP, Antisense Drug Discovery) Option Ex 7,600 10.29 78,204
2015-06-01 Muto Frederick T (Director) Sale 10,000 66.91 669,110
2015-06-01 Muto Frederick T (Director) Option Ex 10,000 3.95 39,500
2015-04-17 Berthelsen Spencer R (Director) Option Ex 10,000 3.95 39,500
2015-04-07 Parshall B Lynne (COO & Secretary) Sale 5,565 63.07 350,990
2015-04-07 Parshall B Lynne (COO & Secretary) Option Ex 5,565 14.69 81,749
2015-04-07 Crooke Stanley T (Chairman and CEO) Sale 22,377 63.07 1,411,339
2015-04-07 Crooke Stanley T (Chairman and CEO) Option Ex 22,377 10.24 229,252
2015-04-01 Parshall B Lynne (COO & Secretary) Sale 5,377 61.93 333,008
2015-04-01 Parshall B Lynne (COO & Secretary) Option Ex 5,377 14.69 78,988
2015-04-01 Crooke Stanley T (Chairman and CEO) Sale 21,623 61.93 1,339,155
2015-04-01 Crooke Stanley T (Chairman and CEO) Option Ex 21,623 10.24 221,527
2015-03-24 Bennett C Frank (SVP, Antisense Research) Sale 9,000 71.01 639,090
2015-03-24 Bennett C Frank (SVP, Antisense Research) Option Ex 9,000 14.47 130,230
2015-03-23 Bennett C Frank (SVP, Antisense Research) Sale 6,000 70.40 422,412
2015-03-23 Bennett C Frank (SVP, Antisense Research) Option Ex 6,000 14.47 86,820
2015-03-19 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 30,525 74.81 2,283,483
2015-03-19 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 30,525 19.82 605,005
2015-03-19 Geary Richard S (SVP, Development) Sale 8,000 75.00 600,032
2015-03-19 Geary Richard S (SVP, Development) Option Ex 8,000 14.69 117,520
2015-03-19 Hougen Elizabeth L (SVP, Finance & CFO) Sale 10,000 73.33 733,259
2015-03-19 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 10,000 11.27 112,700
2015-03-18 Wender Joseph H (Director) Sale 12,500 71.40 892,450
2015-03-18 Wender Joseph H (Director) Option Ex 12,500 5.93 74,125
2015-03-05 O'neil Patrick R. (SVP, Legal & General Counsel) Sale 5,800 71.67 415,674
2015-03-05 O'neil Patrick R. (SVP, Legal & General Counsel) Option Ex 5,800 9.14 53,041
2015-03-05 Geary Richard S (SVP, Development) Sale 18,095 71.33 1,290,734
2015-03-05 Geary Richard S (SVP, Development) Option Ex 15,080 9.60 144,813
2015-03-05 Klein Joseph Iii (Director) Sale 7,000 70.95 496,685
2015-03-05 Klein Joseph Iii (Director) Option Ex 10,000 10.49 104,870
2015-03-05 Hougen Elizabeth L (SVP, Finance & CFO) Sale 28,094 71.55 2,010,153
2015-03-05 Hougen Elizabeth L (SVP, Finance & CFO) Option Ex 28,094 9.66 271,303

Insider trading activities including stock purchases, stock sales, and option exercises of IONS listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Ionis Pharmaceuticals Inc (symbol IONS, CIK number 874015) see the Securities and Exchange Commission (SEC) website.