Insider Trading activities at Opko Health, Inc. (OPK) , Part 2

Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Opko Health, Inc. (OPK) since 2006 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Opko Health, Inc.. (See page 1 of this report.) Table 2 shows the detailed insider transactions. This company's CIK number is 944809.

Total stock buying since 2006: $446,749,594.
Total stock sales since 2006: $4,562,093.
Total stock option exercises since 2006: $44,859,310.

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Table 1. Yearly summary of insider stock purchases, sales, and option exercises at *Opko Health, Inc.* (*OPK*).
	Insider Buying		Insider Sales		Option Exercises
Year	Shares	Value	Shares	Value	Shares	Value
2025	1,464,971	$2,268,356	0	$0	0	$0
2024	11,060,977	$11,232,662	0	$0	0	$0
2023	2,620,245	$4,028,551	0	$0	0	$0
2022	6,065,071	$15,298,160	0	$0	0	$0
2021	1,675,010	$6,733,537	0	$0	60,000	$152,100
2020	6,378,018	$12,211,808	0	$0	0	$0
2019	10,968,536	$20,157,698	0	$0	24,877	$16,418
2018	4,280,235	$15,828,016	0	$0	75,000	$257,250
2017	4,309,300	$29,248,220	112,975	$911,708	781,707	$2,316,267
2016	2,040,400	$18,843,589	37,500	$368,775	280,000	$313,400
2015	3,413,575	$38,939,224	41,488	$606,305	29,803,340	$26,767,986
2014	6,735,138	$56,715,211	226,030	$1,897,224	2,387,169	$5,701,640
2013	5,730,601	$42,219,434	50,000	$335,850	6,951,413	$8,990,168
2012	11,955,478	$54,117,205	0	$0	100,000	$203,700
2011	8,737,635	$32,428,441	50,000	$169,850	50,000	$28,000
2010	1,078,171	$2,505,315	0	$0	0	$0
2009	6,754,517	$6,502,506	0	$0	50,403	$43,094
2008	15,658,469	$25,674,488	100,000	$175,131	395,798	$69,287
2007	20,931,416	$51,795,693	29,500	$97,250	0	$0
2006	2,000	$1,480	0	$0	0	$0

Table 3. Detailed insider trading at *Opko Health, Inc.* (*OPK*) , Part 2
Trade Date	Insider Name	Trade Type	Shares	Price ($)	Value ($)
2019-11-06	Frost Gamma Investments Trust (10% Owner)	Buy	350,000	1.49	522,200
2019-10-31	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.43	71,400
2019-10-30	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	1.45	289,000
2019-10-29	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	1.48	295,600
2019-10-25	Rubin Steven D (Executive VP-Administration)	Buy	15,000	1.50	22,500
2019-10-25	Frost Gamma Investments Trust (10% Owner)	Buy	2,350,000	1.45	3,492,450
2019-10-25	Pfenniger Richard C Jr (Director)	Buy	25,000	1.45	36,250
2019-10-25	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	400,000	1.50	600,000
2019-07-16	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	2.12	105,900
2019-07-12	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	2.15	107,549
2019-07-08	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	2.23	223,100
2019-07-02	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	2.42	120,900
2019-06-25	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	2.01	201,200
2019-06-20	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	2.04	102,150
2019-06-19	Frost Nevada Investments Trust (10% Owner)	Buy	25,000	2.00	50,125
2019-06-18	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	2.02	101,150
2019-06-14	Frost Nevada Investments Trust (10% Owner)	Buy	70,000	1.91	133,980
2019-06-13	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	1.93	96,450
2019-06-12	Frost Nevada Investments Trust (10% Owner)	Buy	15,000	1.82	27,375
2019-06-11	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	1.87	93,400
2019-06-07	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	1.87	93,600
2019-06-06	Frost Nevada Investments Trust (10% Owner)	Buy	25,000	1.92	47,950
2019-06-05	Frost Nevada Investments Trust (10% Owner)	Buy	150,000	1.93	288,900
2019-05-31	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	1.77	176,700
2019-05-30	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	1.87	93,400
2019-05-29	Frost Nevada Investments Trust (10% Owner)	Buy	70,000	1.84	129,080
2019-05-28	Fishel Robert Scott (Director)	Buy	50,000	1.92	96,000
2019-05-28	Frost Nevada Investments Trust (10% Owner)	Buy	200,000	1.91	381,400
2019-05-23	Frost Nevada Investments Trust (10% Owner)	Buy	200,000	1.92	383,600
2019-05-22	Frost Nevada Investments Trust (10% Owner)	Buy	125,000	2.01	251,125
2019-05-22	Pfenniger Richard C Jr (Director)	Buy	30,000	2.05	61,499
2019-05-17	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	2.08	103,850
2019-05-16	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	2.02	202,300
2019-05-14	Frost Nevada Investments Trust (10% Owner)	Buy	1,000,000	1.99	1,992,000
2019-05-13	Frost Nevada Investments Trust (10% Owner)	Buy	200,000	1.99	397,800
2019-05-13	Pfenniger Richard C Jr (Director)	Buy	50,000	2.05	102,400
2019-05-10	Frost Nevada Investments Trust (10% Owner)	Buy	70,000	2.09	146,160
2019-05-09	Frost Nevada Investments Trust (10% Owner)	Buy	285,000	2.07	589,095
2019-05-09	Rubin Steven D (Executive VP-Administration)	Buy	10,000	2.13	21,330
2019-05-09	Logal Adam (Sr. Vice President, CFO)	Buy	3,250	2.04	6,623
2019-05-09	Paganelli John A (Director)	Buy	10,000	2.09	20,880
2019-05-09	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	10,000	2.03	20,330
2019-05-08	Frost Nevada Investments Trust (10% Owner)	Buy	907,000	2.15	1,952,771
2019-04-22	Frost Nevada Investments Trust (10% Owner)	Buy	80,000	2.33	186,080
2019-04-17	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	2.42	120,950
2019-04-16	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	2.50	24,980
2019-04-15	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	2.46	24,650
2019-04-12	Frost Nevada Investments Trust (10% Owner)	Buy	20,000	2.50	49,960
2019-04-11	Frost Nevada Investments Trust (10% Owner)	Buy	30,000	2.49	74,670
2019-04-10	Frost Nevada Investments Trust (10% Owner)	Buy	20,000	2.53	50,640
2019-04-09	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	2.51	25,080
2019-04-04	Frost Nevada Investments Trust (10% Owner)	Buy	20,000	2.53	50,660
2019-04-02	Frost Nevada Investments Trust (10% Owner)	Buy	40,000	2.53	101,120
2019-04-01	Frost Nevada Investments Trust (10% Owner)	Buy	20,000	2.59	51,720
2019-03-27	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	2.49	248,800
2019-03-18	Frost Nevada Investments Trust (10% Owner)	Buy	40,000	2.47	98,920
2019-03-14	Frost Nevada Investments Trust (10% Owner)	Buy	250,000	2.44	611,000
2019-03-06	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	2.58	128,750
2019-03-06	Rubin Steven D (Executive VP-Administration)	Buy	8,000	2.56	20,464
2019-02-28	Frost Nevada Investments Trust (10% Owner)	Buy	200,000	2.48	495,600
2019-02-01	Rubin Steven D (Executive VP-Administration)	Option Ex	24,877	.66	16,418
2019-01-17	Frost Nevada Investments Trust (10% Owner)	Buy	15,000	3.68	55,170
2019-01-16	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	3.74	37,360
2019-01-14	Frost Nevada Investments Trust (10% Owner)	Buy	15,000	3.74	56,070
2019-01-11	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	3.83	38,330
2019-01-10	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	3.69	36,900
2019-01-09	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	3.65	36,500
2019-01-08	Frost Nevada Investments Trust (10% Owner)	Buy	35,000	3.61	126,315
2019-01-07	Frost Nevada Investments Trust (10% Owner)	Buy	55,000	3.55	195,195
2019-01-04	Frost Nevada Investments Trust (10% Owner)	Buy	30,000	3.40	102,000
2019-01-03	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	3.25	162,350
2019-01-02	Frost Nevada Investments Trust (10% Owner)	Buy	40,000	3.23	129,360
2018-12-31	Frost Nevada Investments Trust (10% Owner)	Buy	135,000	2.98	402,840
2018-12-28	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	3.14	313,900
2018-09-07	Fishel Robert Scott (Director)	Buy	10,000	4.63	46,300
2018-09-07	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	5.58	55,810
2018-09-05	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	5.80	57,980
2018-08-30	Frost Nevada Investments Trust (10% Owner)	Buy	5,000	5.89	29,474
2018-08-28	Frost Nevada Investments Trust (10% Owner)	Buy	5,000	5.80	28,990
2018-08-24	Frost Nevada Investments Trust (10% Owner)	Buy	15,000	5.69	85,410
2018-08-17	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	5.55	55,500
2018-08-13	Frost Nevada Investments Trust (10% Owner)	Buy	15,000	5.33	80,010
2018-08-09	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	5.45	54,530
2018-07-26	Frost Nevada Investments Trust (10% Owner)	Buy	90,000	5.06	455,040
2018-07-25	Frost Nevada Investments Trust (10% Owner)	Buy	60,000	5.47	328,260
2018-07-24	Frost Nevada Investments Trust (10% Owner)	Buy	55,000	5.59	307,505
2018-07-20	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	5.89	58,900
2018-07-19	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	5.95	59,500
2018-07-18	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	6.05	60,500
2018-07-16	Frost Nevada Investments Trust (10% Owner)	Buy	15,000	5.69	85,395
2018-07-11	Fishel Robert Scott (Director)	Buy	2,500	6.00	14,992
2018-07-03	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	4.75	47,460
2018-06-29	Frost Nevada Investments Trust (10% Owner)	Buy	7,720	4.69	36,206
2018-06-28	Frost Nevada Investments Trust (10% Owner)	Buy	20,000	4.68	93,600
2018-06-27	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	4.75	47,500
2018-06-22	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	4.45	44,500
2018-06-21	Frost Nevada Investments Trust (10% Owner)	Buy	30,000	4.54	136,200
2018-06-19	Frost Nevada Investments Trust (10% Owner)	Buy	20,000	4.32	86,300
2018-06-18	Frost Nevada Investments Trust (10% Owner)	Buy	14,299	4.33	61,943
2018-06-15	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	4.42	44,200
2018-06-11	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	4.22	42,200
2018-06-08	Logal Adam (Sr. Vice President, CFO)	Option Ex	75,000	3.43	257,250
2018-06-07	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	4.04	40,400
2018-06-06	Frost Nevada Investments Trust (10% Owner)	Buy	30,000	4.05	121,500
2018-05-31	Frost Nevada Investments Trust (10% Owner)	Buy	3,900	3.76	14,664
2018-05-29	Fishel Robert Scott (Director)	Buy	2,500	3.73	9,332
2018-05-25	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	3.70	37,000
2018-05-23	Frost Nevada Investments Trust (10% Owner)	Buy	40,000	3.73	149,320
2018-05-22	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	3.73	37,300
2018-05-21	Frost Nevada Investments Trust (10% Owner)	Buy	90,000	3.81	343,350
2018-05-18	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	4.03	403,400
2018-05-14	Fishel Robert Scott (Director)	Buy	1,800	4.79	8,622
2018-05-04	Fishel Robert Scott (Director)	Buy	5,000	3.14	15,700
2018-05-04	Frost Nevada Investments Trust (10% Owner)	Buy	26,000	3.13	81,510
2018-05-03	Frost Nevada Investments Trust (10% Owner)	Buy	51,800	3.09	160,217
2018-05-02	Frost Nevada Investments Trust (10% Owner)	Buy	50,330	3.15	158,388
2018-05-01	Frost Nevada Investments Trust (10% Owner)	Buy	31,222	3.05	95,227
2018-04-30	Frost Nevada Investments Trust (10% Owner)	Buy	75,000	3.10	232,725
2018-04-26	Frost Nevada Investments Trust (10% Owner)	Buy	31,800	3.03	96,385
2018-04-25	Fishel Robert Scott (Director)	Buy	12,500	2.98	37,250
2018-04-25	Frost Nevada Investments Trust (10% Owner)	Buy	55,372	2.99	165,340
2018-04-24	Frost Nevada Investments Trust (10% Owner)	Buy	75,000	2.95	221,325
2018-04-23	Frost Nevada Investments Trust (10% Owner)	Buy	75,000	3.04	227,850
2018-04-20	Frost Nevada Investments Trust (10% Owner)	Buy	60,000	3.13	187,680
2018-04-19	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	3.17	31,700
2018-04-16	Fishel Robert Scott (Director)	Buy	15,000	3.00	45,075
2018-04-16	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	3.01	150,600
2018-04-13	Fishel Robert Scott (Director)	Buy	10,000	3.02	30,200
2018-04-13	Frost Nevada Investments Trust (10% Owner)	Buy	30,000	3.00	89,850
2018-04-12	Frost Nevada Investments Trust (10% Owner)	Buy	65,000	3.04	197,405
2018-04-11	Frost Nevada Investments Trust (10% Owner)	Buy	43,000	3.06	131,451
2018-04-10	Frost Nevada Investments Trust (10% Owner)	Buy	36,527	3.05	111,334
2018-04-09	Frost Nevada Investments Trust (10% Owner)	Buy	80,000	3.05	243,680
2018-04-06	Fishel Robert Scott (Director)	Buy	10,000	3.16	31,600
2018-04-06	Frost Nevada Investments Trust (10% Owner)	Buy	60,000	3.10	185,760
2018-04-05	Frost Nevada Investments Trust (10% Owner)	Buy	10,000	3.25	32,500
2018-04-03	Frost Nevada Investments Trust (10% Owner)	Buy	153,000	2.98	455,787
2018-03-28	Frost Nevada Investments Trust (10% Owner)	Buy	80,000	3.07	245,760
2018-03-27	Frost Nevada Investments Trust (10% Owner)	Buy	86,100	3.24	278,877
2018-03-26	Frost Nevada Investments Trust (10% Owner)	Buy	26,000	3.20	83,148
2018-03-23	Frost Nevada Investments Trust (10% Owner)	Buy	25,000	3.27	81,700
2018-03-22	Frost Nevada Investments Trust (10% Owner)	Buy	30,000	3.31	99,240
2018-03-21	Frost Nevada Investments Trust (10% Owner)	Buy	30,000	3.38	101,280
2018-03-20	Frost Nevada Investments Trust (10% Owner)	Buy	75,000	3.33	250,125
2018-03-19	Frost Nevada Investments Trust (10% Owner)	Buy	40,000	3.50	140,040
2018-03-15	Frost Nevada Investments Trust (10% Owner)	Buy	61,000	3.33	202,886
2018-03-13	Frost Nevada Investments Trust (10% Owner)	Buy	67,500	3.37	227,340
2018-03-13	Logal Adam (Sr. Vice President, CFO)	Buy	2,065	3.40	7,016
2018-03-12	Frost Nevada Investments Trust (10% Owner)	Buy	25,000	3.48	86,975
2018-03-08	Frost Nevada Investments Trust (10% Owner)	Buy	32,000	3.29	105,216

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Insider trading activities including stock purchases, stock sales, and option exercises of OPK listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Opko Health, Inc. (symbol OPK, CIK number 944809) see the Securities and Exchange Commission (SEC) website.

▪ Real-time Insider Trading

▪ Insider Officer Cluster Trading

▪ Top Officer Buys of the Week

▪ Top Officer Buys of the Month