Insider Trading activities of Opko Health, Inc. insiders.

Monthly summaries of insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Opko Health, Inc. since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Opko Health, Inc. since year 2005. Table 2 shows the detailed insider transactions of Opko Health, Inc. since 2005. The reporting company's ticker symbol is OPK. The reporting company's CIK number is 944809.
The total value of stock buying since 2005 is $368,457,293.
The total value of stock sales since 2005 is $4,562,093.
The total value of stock option exercises since 2005 is $44,433,542.


Table 1. Monthly summaries of insider stock purchases, sales, and option exercises for Opko Health, Inc. (OPK).
Trading Period Insider Buying Insider Sales Option Exercises
year-month Shares Value Shares Value Shares Value
2018-04 572,527 $1,736,942 0 $0 0 $0
2018-03 1,025,465 $3,249,459 0 $0 0 $0
2018-02 620,500 $2,437,820 0 $0 0 $0
2018-01 495,000 $2,338,365 0 $0 0 $0
2017-09 396,500 $2,375,150 0 $0 0 $0
2017-08 342,400 $2,100,301 0 $0 0 $0
2017-07 338,900 $2,150,972 0 $0 0 $0
2017-06 549,600 $3,558,311 0 $0 20,000 $68,600
2017-05 1,948,400 $13,241,539 0 $0 0 $0
2017-04 323,800 $2,460,920 0 $0 285,000 $719,800
2017-03 179,200 $1,381,207 112,975 $911,708 284,207 $426,742
2017-02 90,200 $752,792 0 $0 0 $0
2017-01 140,300 $1,227,028 0 $0 192,500 $1,101,125
2016-12 30,800 $293,764 0 $0 0 $0
2016-11 89,900 $870,106 0 $0 0 $0
2016-10 114,400 $1,094,114 0 $0 0 $0
2016-09 57,000 $577,059 0 $0 0 $0
2016-08 189,200 $1,816,214 0 $0 0 $0
2016-07 35,800 $349,963 0 $0 0 $0
2016-06 296,200 $2,777,775 0 $0 0 $0
2016-05 131,700 $1,320,479 37,500 $368,775 250,000 $290,000
2016-04 125,400 $1,336,148 0 $0 0 $0
2016-03 282,900 $2,796,710 0 $0 0 $0
2016-02 233,900 $1,878,626 0 $0 0 $0
2016-01 453,200 $3,732,631 0 $0 30,000 $23,400
2015-12 285,300 $2,886,963 0 $0 0 $0
2015-11 189,100 $1,945,405 0 $0 0 $0
2015-10 176,100 $1,568,896 0 $0 20,000 $68,600
2015-09 659,700 $6,267,426 0 $0 35,000 $24,079
2015-08 1,107,200 $13,158,946 0 $0 1,281,574 $7,686,766
2015-07 25,200 $412,080 0 $0 20,000 $35,600
2015-06 188,675 $2,930,789 0 $0 0 $0
2015-05 71,500 $1,018,976 0 $0 0 $0
2015-04 163,400 $2,331,485 0 $0 0 $0
2015-03 178,200 $2,523,873 41,488 $606,305 95,000 $133,475
2015-02 50,000 $643,050 0 $0 0 $0
2015-01 319,200 $3,251,335 0 $0 28,351,766 $18,819,466
2014-12 157,500 $1,537,769 0 $0 0 $0
2014-11 458,700 $3,795,394 0 $0 221,048 $28,852
2014-10 593,000 $4,924,248 0 $0 0 $0
2014-09 495,800 $4,195,454 0 $0 201,613 $500,000
2014-08 309,700 $2,751,978 0 $0 309,583 $1,294,056
2014-07 376,300 $3,318,021 0 $0 654,925 $1,028,232
2014-06 420,500 $3,789,111 0 $0 20,000 $24,600
2014-05 460,700 $3,795,540 0 $0 0 $0
2014-04 786,400 $6,640,779 179,300 $1,500,347 740,000 $2,351,900
2014-03 435,700 $4,042,921 0 $0 100,000 $146,700
2014-02 932,060 $7,284,913 0 $0 0 $0
2014-01 1,298,778 $10,559,483 46,730 $396,877 140,000 $327,300
2013-12 687,700 $6,115,583 0 $0 3,554,773 $8,937,568
2013-11 317,200 $3,195,865 0 $0 0 $0
2013-10 133,700 $1,382,367 0 $0 20,000 $24,600
2013-09 35,000 $297,124 0 $0 0 $0
2013-07 314,500 $2,308,387 0 $0 0 $0
2013-06 646,401 $4,242,995 0 $0 0 $0
2013-05 880,500 $6,007,468 0 $0 0 $0
2013-04 861,100 $6,073,234 0 $0 0 $0
2013-03 658,000 $4,871,764 0 $0 3,326,640 $0
2013-02 880,500 $6,009,363 50,000 $335,850 50,000 $28,000
2013-01 316,000 $1,715,284 0 $0 0 $0
2012-12 900,000 $4,129,623 0 $0 100,000 $203,700
2012-11 907,500 $3,971,865 0 $0 0 $0
2012-10 1,375,900 $5,982,989 0 $0 0 $0
2012-09 955,000 $4,108,224 0 $0 0 $0
2012-08 1,432,500 $6,114,246 0 $0 0 $0
2012-07 1,300,000 $5,844,583 0 $0 0 $0
2012-06 850,000 $3,907,505 0 $0 0 $0
2012-05 1,065,900 $4,870,172 0 $0 0 $0
2012-04 1,090,000 $5,091,828 0 $0 0 $0
2012-03 1,320,011 $6,465,785 0 $0 0 $0
2012-02 591,167 $2,833,115 0 $0 0 $0
2012-01 117,500 $580,771 0 $0 0 $0
2011-12 260,000 $1,257,525 0 $0 0 $0
2011-11 290,000 $1,483,125 0 $0 0 $0
2011-10 3,652,222 $13,147,999 0 $0 0 $0
2011-09 70,000 $308,830 0 $0 0 $0
2011-08 689,500 $2,646,867 0 $0 0 $0
2011-07 100,000 $412,500 0 $0 0 $0
2011-06 514,959 $1,773,903 50,000 $169,850 50,000 $28,000
2011-05 245,454 $919,295 0 $0 0 $0
2011-04 105,000 $392,930 0 $0 0 $0
2011-03 1,390,000 $5,042,305 0 $0 0 $0
2011-02 30,000 $132,660 0 $0 0 $0
2011-01 1,390,500 $4,910,502 0 $0 0 $0
2010-12 92,500 $323,850 0 $0 0 $0
2010-11 151,000 $443,966 0 $0 0 $0
2010-10 70,000 $176,555 0 $0 0 $0
2010-09 87,500 $189,821 0 $0 0 $0
2010-08 132,500 $303,648 0 $0 0 $0
2010-07 43,500 $98,407 0 $0 0 $0
2010-06 77,500 $159,416 0 $0 0 $0
2010-05 102,000 $209,905 0 $0 0 $0
2010-04 18,000 $37,824 0 $0 0 $0
2010-03 102,500 $206,289 0 $0 0 $0
2010-02 67,500 $122,740 0 $0 0 $0
2010-01 133,671 $232,894 0 $0 0 $0
2009-12 40,000 $65,980 0 $0 0 $0
2009-11 80,000 $166,840 0 $0 0 $0
2009-10 215,000 $475,050 0 $0 0 $0
2009-08 60,000 $123,140 0 $0 0 $0
2009-07 984,734 $1,718,826 0 $0 0 $0
2009-06 65,100 $102,751 0 $0 0 $0
2009-05 243,600 $255,693 0 $0 0 $0
2009-04 43,200 $45,892 0 $0 0 $0
2009-03 3,971,414 $2,491,361 0 $0 0 $0
2009-02 1,051,469 $1,056,973 0 $0 0 $0
2009-01 0 $0 0 $0 50,403 $43,094
2008-12 20,000 $27,990 0 $0 0 $0
2008-11 605,000 $636,274 0 $0 0 $0
2008-10 73,000 $101,170 0 $0 0 $0
2008-09 60,100 $93,127 100,000 $175,131 100,000 $55,998
2008-07 1,474,782 $2,005,309 0 $0 0 $0
2008-06 240,500 $427,820 0 $0 95,798 $4,789
2008-05 3,227,400 $4,082,892 0 $0 0 $0
2008-04 309,200 $563,963 0 $0 100,000 $4,500
2008-03 527,198 $1,139,528 0 $0 100,000 $4,000
2008-02 9,093,289 $16,517,255 0 $0 0 $0
2008-01 28,000 $79,160 0 $0 0 $0
2007-12 10,964,565 $20,290,886 0 $0 0 $0
2007-11 55,000 $205,440 29,500 $97,250 0 $0
2007-10 66,500 $272,171 0 $0 0 $0
2007-09 103,970 $419,596 0 $0 0 $0
2007-08 157,000 $621,540 0 $0 0 $0
2007-07 9,543,720 $29,796,312 0 $0 0 $0
2007-05 18,161 $87,073 0 $0 0 $0
2007-04 22,500 $102,675 0 $0 0 $0
2006-08 2,000 $1,480 0 $0 0 $0

Table 2. Detailed insider stock purchases, sales, and option exercises of Opko Health, Inc. insiders (OPK)
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2018-04-19 Frost Nevada Investments Trust (10% Owner) Buy 10,000 3.17 31,700
2018-04-16 Fishel Robert Scott (Director) Buy 15,000 3.00 45,075
2018-04-16 Frost Nevada Investments Trust (10% Owner) Buy 50,000 3.01 150,600
2018-04-13 Fishel Robert Scott (Director) Buy 10,000 3.02 30,200
2018-04-13 Frost Nevada Investments Trust (10% Owner) Buy 30,000 3.00 89,850
2018-04-12 Frost Nevada Investments Trust (10% Owner) Buy 65,000 3.04 197,405
2018-04-11 Frost Nevada Investments Trust (10% Owner) Buy 43,000 3.06 131,451
2018-04-10 Frost Nevada Investments Trust (10% Owner) Buy 36,527 3.05 111,334
2018-04-09 Frost Nevada Investments Trust (10% Owner) Buy 80,000 3.05 243,680
2018-04-06 Fishel Robert Scott (Director) Buy 10,000 3.16 31,600
2018-04-06 Frost Nevada Investments Trust (10% Owner) Buy 60,000 3.10 185,760
2018-04-05 Frost Nevada Investments Trust (10% Owner) Buy 10,000 3.25 32,500
2018-04-03 Frost Nevada Investments Trust (10% Owner) Buy 153,000 2.98 455,787
2018-03-28 Frost Nevada Investments Trust (10% Owner) Buy 80,000 3.07 245,760
2018-03-27 Frost Nevada Investments Trust (10% Owner) Buy 86,100 3.24 278,877
2018-03-26 Frost Nevada Investments Trust (10% Owner) Buy 26,000 3.20 83,148
2018-03-23 Frost Nevada Investments Trust (10% Owner) Buy 25,000 3.27 81,700
2018-03-22 Frost Nevada Investments Trust (10% Owner) Buy 30,000 3.31 99,240
2018-03-21 Frost Nevada Investments Trust (10% Owner) Buy 30,000 3.38 101,280
2018-03-20 Frost Nevada Investments Trust (10% Owner) Buy 75,000 3.33 250,125
2018-03-19 Frost Nevada Investments Trust (10% Owner) Buy 40,000 3.50 140,040
2018-03-15 Frost Nevada Investments Trust (10% Owner) Buy 61,000 3.33 202,886
2018-03-13 Frost Nevada Investments Trust (10% Owner) Buy 67,500 3.37 227,340
2018-03-13 Logal Adam (Sr. Vice President, CFO) Buy 2,065 3.40 7,016
2018-03-12 Frost Nevada Investments Trust (10% Owner) Buy 25,000 3.48 86,975
2018-03-08 Frost Nevada Investments Trust (10% Owner) Buy 32,000 3.29 105,216
2018-03-07 Frost Nevada Investments Trust (10% Owner) Buy 75,000 3.29 246,750
2018-03-07 Rubin Steven D (Executive VP-Administration) Buy 6,000 3.25 19,500
2018-03-02 Frost Nevada Investments Trust (10% Owner) Buy 364,800 2.94 1,073,606
2018-02-21 Frost Nevada Investments Trust (10% Owner) Buy 172,500 3.62 625,312
2018-02-09 Frost Nevada Investments Trust (10% Owner) Buy 185,000 3.83 708,365
2018-02-08 Frost Nevada Investments Trust (10% Owner) Buy 20,000 4.04 80,760
2018-02-07 Frost Nevada Investments Trust (10% Owner) Buy 78,000 4.22 329,004
2018-02-06 Frost Nevada Investments Trust (10% Owner) Buy 60,000 4.19 251,520
2018-02-05 Frost Nevada Investments Trust (10% Owner) Buy 50,000 4.12 206,250
2018-02-02 Frost Nevada Investments Trust (10% Owner) Buy 55,000 4.30 236,609
2018-01-31 Frost Nevada Investments Trust (10% Owner) Buy 65,000 4.46 289,770
2018-01-26 Frost Nevada Investments Trust (10% Owner) Buy 55,000 4.92 270,545
2018-01-25 Frost Nevada Investments Trust (10% Owner) Buy 75,000 4.98 373,650
2018-01-24 Frost Nevada Investments Trust (10% Owner) Buy 100,000 4.90 490,200
2018-01-23 Frost Nevada Investments Trust (10% Owner) Buy 100,000 4.76 476,100
2018-01-22 Frost Nevada Investments Trust (10% Owner) Buy 100,000 4.38 438,100
2017-09-19 Frost Nevada Investments Trust (10% Owner) Buy 15,000 6.00 90,045
2017-09-18 Frost Nevada Investments Trust (10% Owner) Buy 40,000 6.00 240,080
2017-09-15 Frost Nevada Investments Trust (10% Owner) Buy 80,000 6.00 480,400
2017-09-15 Logal Adam (Sr. Vice President, CFO) Buy 1,500 6.03 9,045
2017-09-14 Frost Nevada Investments Trust (10% Owner) Buy 260,000 5.98 1,555,580
2017-08-25 Frost Gamma Investments Trust (10% Owner) Buy 25,000 6.18 154,500
2017-08-24 Frost Gamma Investments Trust (10% Owner) Buy 10,000 6.23 62,340
2017-08-23 Frost Gamma Investments Trust (10% Owner) Buy 12,000 6.12 73,452
2017-08-22 Frost Gamma Investments Trust (10% Owner) Buy 1,800 6.13 11,034
2017-08-21 Frost Gamma Investments Trust (10% Owner) Buy 25,000 6.09 152,150
2017-08-17 Frost Gamma Investments Trust (10% Owner) Buy 50,000 5.94 297,200
2017-08-16 Frost Gamma Investments Trust (10% Owner) Buy 40,000 6.04 241,759
2017-08-15 Frost Gamma Investments Trust (10% Owner) Buy 25,000 6.09 152,200
2017-08-14 Frost Gamma Investments Trust (10% Owner) Buy 10,000 6.15 61,480
2017-08-11 Frost Gamma Investments Trust (10% Owner) Buy 10,000 6.18 61,790
2017-08-10 Frost Gamma Investments Trust (10% Owner) Buy 39,000 6.23 243,048
2017-08-09 Frost Gamma Investments Trust (10% Owner) Buy 18,000 6.34 114,084
2017-08-08 Frost Gamma Investments Trust (10% Owner) Buy 5,000 6.05 30,250
2017-08-02 Frost Gamma Investments Trust (10% Owner) Buy 25,000 6.14 153,625
2017-08-01 Frost Gamma Investments Trust (10% Owner) Buy 46,600 6.25 291,389
2017-07-28 Frost Gamma Investments Trust (10% Owner) Buy 35,100 6.29 220,849
2017-07-27 Frost Gamma Investments Trust (10% Owner) Buy 23,600 6.34 149,718
2017-07-26 Frost Gamma Investments Trust (10% Owner) Buy 36,200 6.38 231,064
2017-07-25 Frost Gamma Investments Trust (10% Owner) Buy 39,800 6.42 255,396
2017-07-24 Frost Gamma Investments Trust (10% Owner) Buy 45,000 6.42 288,945
2017-07-20 Frost Gamma Investments Trust (10% Owner) Buy 5,400 6.46 34,873
2017-07-17 Frost Gamma Investments Trust (10% Owner) Buy 1,800 6.04 10,868
2017-07-14 Frost Gamma Investments Trust (10% Owner) Buy 12,600 6.15 77,477
2017-07-12 Frost Gamma Investments Trust (10% Owner) Buy 3,600 6.12 22,050
2017-07-10 Frost Gamma Investments Trust (10% Owner) Buy 50,000 6.20 309,850
2017-07-06 Frost Gamma Investments Trust (10% Owner) Buy 25,000 6.29 157,175
2017-07-03 Frost Gamma Investments Trust (10% Owner) Buy 60,800 6.46 392,707
2017-06-30 Frost Gamma Investments Trust (10% Owner) Buy 3,600 6.58 23,706
2017-06-28 Frost Gamma Investments Trust (10% Owner) Buy 1,800 6.87 12,366
2017-06-27 Frost Gamma Investments Trust (10% Owner) Buy 21,800 6.77 147,673
2017-06-26 Frost Gamma Investments Trust (10% Owner) Buy 1,800 6.96 12,537
2017-06-22 Frost Gamma Investments Trust (10% Owner) Buy 131,000 6.72 880,320
2017-06-15 Frost Gamma Investments Trust (10% Owner) Buy 200,000 6.42 1,284,000
2017-06-13 Frost Gamma Investments Trust (10% Owner) Buy 7,200 6.51 46,843
2017-06-12 Frost Gamma Investments Trust (10% Owner) Buy 1,800 6.37 11,457
2017-06-09 Frost Gamma Investments Trust (10% Owner) Buy 25,000 6.38 159,525
2017-06-07 Frost Gamma Investments Trust (10% Owner) Buy 55,600 6.28 349,279
2017-06-06 Frost Gamma Investments Trust (10% Owner) Buy 30,000 6.31 189,180
2017-06-05 Frost Gamma Investments Trust (10% Owner) Buy 55,000 6.32 347,435
2017-06-05 Lerner Richard A (Director) Buy 10,000 6.32 63,150
2017-06-02 Pfenniger Richard C Jr (Director) Option Ex 20,000 3.43 68,600
2017-06-01 Paganelli John A (Director) Buy 5,000 6.17 30,840
2017-05-31 Rubin Steven D (Executive VP-Administration) Buy 2,000 6.10 12,200
2017-05-31 Frost Gamma Investments Trust (10% Owner) Buy 207,700 6.14 1,275,485
2017-05-30 Frost Gamma Investments Trust (10% Owner) Buy 18,600 6.28 116,715
2017-05-26 Frost Gamma Investments Trust (10% Owner) Buy 64,600 6.30 406,915
2017-05-25 Frost Gamma Investments Trust (10% Owner) Buy 26,000 6.39 166,114
2017-05-24 Frost Gamma Investments Trust (10% Owner) Buy 42,200 6.42 270,966
2017-05-22 Frost Gamma Investments Trust (10% Owner) Buy 120,000 6.46 774,600
2017-05-19 Frost Gamma Investments Trust (10% Owner) Buy 9,200 6.59 60,674
2017-05-18 Frost Gamma Investments Trust (10% Owner) Buy 20,000 6.59 131,880
2017-05-17 Frost Gamma Investments Trust (10% Owner) Buy 70,800 6.54 462,678
2017-05-16 Frost Gamma Investments Trust (10% Owner) Buy 27,800 6.61 183,758
2017-05-11 Rubin Steven D (Executive VP-Administration) Buy 2,000 6.91 13,810
2017-05-11 Hsiao Jane Ph D (Vice Chairman & CTO) Buy 20,000 6.92 138,500
2017-05-10 Frost Gamma Investments Trust (10% Owner) Buy 1,125,000 6.96 7,830,000
2017-05-10 Hsiao Jane Ph D (Vice Chairman & CTO) Buy 40,000 6.97 278,640
2017-05-08 Frost Gamma Investments Trust (10% Owner) Buy 100,000 7.22 722,000
2017-05-05 Frost Gamma Investments Trust (10% Owner) Buy 10,000 7.52 75,160
2017-05-04 Frost Gamma Investments Trust (10% Owner) Buy 11,800 7.50 88,523
2017-05-03 Frost Gamma Investments Trust (10% Owner) Buy 11,000 7.54 82,918
2017-05-02 Frost Gamma Investments Trust (10% Owner) Buy 15,000 7.56 113,400
2017-05-01 Frost Gamma Investments Trust (10% Owner) Buy 4,700 7.79 36,603
2017-04-28 Frost Gamma Investments Trust (10% Owner) Buy 9,000 7.78 70,002
2017-04-27 Frost Gamma Investments Trust (10% Owner) Buy 22,500 7.81 175,680
2017-04-26 Frost Gamma Investments Trust (10% Owner) Buy 5,000 7.84 39,190
2017-04-21 Frost Gamma Investments Trust (10% Owner) Buy 19,000 7.49 142,310
2017-04-19 Frost Gamma Investments Trust (10% Owner) Buy 15,000 7.48 112,230
2017-04-18 Frost Gamma Investments Trust (10% Owner) Buy 27,800 7.27 202,050
2017-04-17 Frost Gamma Investments Trust (10% Owner) Buy 13,600 7.48 101,687
2017-04-13 Frost Gamma Investments Trust (10% Owner) Buy 30,800 7.57 233,032
2017-04-12 Rubin Steven D (Executive VP-Administration) Option Ex 265,000 2.36 625,400
2017-04-11 Frost Gamma Investments Trust (10% Owner) Buy 18,000 7.50 134,946
2017-04-10 Yu Alice Lin-tsing (Director) Option Ex 20,000 4.72 94,400
2017-04-10 Frost Gamma Investments Trust (10% Owner) Buy 33,000 7.62 251,361
2017-04-07 Frost Gamma Investments Trust (10% Owner) Buy 28,000 7.58 212,240
2017-04-06 Frost Gamma Investments Trust (10% Owner) Buy 28,600 7.58 216,902
2017-04-05 Frost Gamma Investments Trust (10% Owner) Buy 44,500 7.71 343,050
2017-04-04 Frost Gamma Investments Trust (10% Owner) Buy 7,400 7.68 56,832
2017-04-03 Frost Gamma Investments Trust (10% Owner) Buy 21,600 7.84 169,408
2017-03-31 Frost Gamma Investments Trust (10% Owner) Buy 1,800 8.00 14,400
2017-03-30 Frost Gamma Investments Trust (10% Owner) Buy 10,600 8.01 84,927
2017-03-29 Frost Gamma Investments Trust (10% Owner) Buy 9,200 8.14 74,897
2017-03-28 Frost Gamma Investments Trust (10% Owner) Buy 3,600 8.03 28,890
2017-03-24 Frost Gamma Investments Trust (10% Owner) Buy 3,600 7.76 27,921
2017-03-23 Frost Gamma Investments Trust (10% Owner) Buy 12,200 7.72 94,220
2017-03-21 Frost Gamma Investments Trust (10% Owner) Buy 5,800 7.83 45,443
2017-03-20 Frost Gamma Investments Trust (10% Owner) Buy 11,000 7.99 87,879
2017-03-17 Frost Gamma Investments Trust (10% Owner) Buy 9,000 8.19 73,710
2017-03-15 Frost Gamma Investments Trust (10% Owner) Buy 1,800 8.03 14,450
2017-03-14 Logal Adam (Sr. Vice President, CFO) Sale 112,975 8.07 911,708
2017-03-13 Logal Adam (Sr. Vice President, CFO) Option Ex 264,207 1.46 385,742
2017-03-13 Lerner Richard A (Director) Option Ex 20,000 2.05 41,000
2017-03-10 Frost Gamma Investments Trust (10% Owner) Buy 1,800 7.97 14,340
2017-03-09 Frost Gamma Investments Trust (10% Owner) Buy 3,600 7.85 28,245
2017-03-08 Frost Gamma Investments Trust (10% Owner) Buy 1,800 7.92 14,256
2017-03-03 Frost Gamma Investments Trust (10% Owner) Buy 8,600 7.43 63,880
2017-03-02 Frost Gamma Investments Trust (10% Owner) Buy 94,800 7.53 713,749
2017-02-24 Frost Gamma Investments Trust (10% Owner) Buy 3,600 8.46 30,463
2017-02-23 Frost Gamma Investments Trust (10% Owner) Buy 1,800 8.39 15,098
2017-02-22 Frost Gamma Investments Trust (10% Owner) Buy 1,800 8.54 15,363
2017-02-21 Frost Gamma Investments Trust (10% Owner) Buy 3,600 8.80 31,680
2017-02-17 Frost Gamma Investments Trust (10% Owner) Buy 1,800 8.79 15,827

Insider trading activities including stock purchases, stock sales, and option exercises of OPK listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Opko Health, Inc. (symbol OPK, CIK number 944809) see the Securities and Exchange Commission (SEC) website.