Insider Trading activities at Opko Health, Inc. (OPK)

Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Opko Health, Inc. (OPK) since 2006 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Opko Health, Inc.. Table 2 shows the detailed insider transactions. This company's CIK number is 944809.

Total stock buying since 2006: $446,749,594.
Total stock sales since 2006: $4,562,093.
Total stock option exercises since 2006: $44,859,310.

1 2 3 4 5 6 7 8 9 10 11

Table 1. Yearly summary of insider stock purchases, sales, and option exercises at *Opko Health, Inc.* (*OPK*).
	Insider Buying		Insider Sales		Option Exercises
Year	Shares	Value	Shares	Value	Shares	Value
2025	1,464,971	$2,268,356	0	$0	0	$0
2024	11,060,977	$11,232,662	0	$0	0	$0
2023	2,620,245	$4,028,551	0	$0	0	$0
2022	6,065,071	$15,298,160	0	$0	0	$0
2021	1,675,010	$6,733,537	0	$0	60,000	$152,100
2020	6,378,018	$12,211,808	0	$0	0	$0
2019	10,968,536	$20,157,698	0	$0	24,877	$16,418
2018	4,280,235	$15,828,016	0	$0	75,000	$257,250
2017	4,309,300	$29,248,220	112,975	$911,708	781,707	$2,316,267
2016	2,040,400	$18,843,589	37,500	$368,775	280,000	$313,400
2015	3,413,575	$38,939,224	41,488	$606,305	29,803,340	$26,767,986
2014	6,735,138	$56,715,211	226,030	$1,897,224	2,387,169	$5,701,640
2013	5,730,601	$42,219,434	50,000	$335,850	6,951,413	$8,990,168
2012	11,955,478	$54,117,205	0	$0	100,000	$203,700
2011	8,737,635	$32,428,441	50,000	$169,850	50,000	$28,000
2010	1,078,171	$2,505,315	0	$0	0	$0
2009	6,754,517	$6,502,506	0	$0	50,403	$43,094
2008	15,658,469	$25,674,488	100,000	$175,131	395,798	$69,287
2007	20,931,416	$51,795,693	29,500	$97,250	0	$0
2006	2,000	$1,480	0	$0	0	$0

Table 2. Monthly summary of insider trading at *Opko Health, Inc.* (*OPK*).
Trading Period	Insider Buying		Insider Sales		Option Exercises
year-month	Shares	Value	Shares	Value	Shares	Value
2025-04	350,000	$519,275	0	$0	0	$0
2025-03	350,000	$602,200	0	$0	0	$0
2025-02	67,434	$115,312	0	$0	0	$0
2025-01	697,537	$1,031,569	0	$0	0	$0
2024-12	500,000	$781,000	0	$0	0	$0
2024-11	679,255	$1,048,051	0	$0	0	$0
2024-05	263,997	$337,927	0	$0	0	$0
2024-03	2,100,000	$1,904,700	0	$0	0	$0
2024-02	3,000,000	$2,950,500	0	$0	0	$0
2024-01	4,517,725	$4,210,484	0	$0	0	$0
2023-11	35,000	$45,500	0	$0	0	$0
2023-08	925,000	$1,683,025	0	$0	0	$0
2023-05	460,245	$839,026	0	$0	0	$0
2023-03	1,200,000	$1,461,000	0	$0	0	$0
2022-11	500,000	$767,100	0	$0	0	$0
2022-10	575,000	$1,010,175	0	$0	0	$0
2022-09	600,000	$1,195,399	0	$0	0	$0
2022-08	550,000	$1,306,649	0	$0	0	$0
2022-06	790,000	$1,974,560	0	$0	0	$0
2022-05	1,465,071	$4,203,202	0	$0	0	$0
2022-03	135,000	$418,725	0	$0	0	$0
2022-02	1,100,000	$3,383,550	0	$0	0	$0
2022-01	350,000	$1,038,800	0	$0	0	$0
2021-09	100,000	$346,100	0	$0	0	$0

Table 3. Detailed insider trading at *Opko Health, Inc.* (*OPK*)
Trade Date	Insider Name	Trade Type	Shares	Price ($)	Value ($)
2025-04-10	Frost Gamma Investments Trust	Buy	125,000	1.36	169,750
2025-04-08	Frost Gamma Investments Trust	Buy	125,000	1.48	184,625
2025-04-01	Frost Gamma Investments Trust	Buy	100,000	1.65	164,900
2025-03-28	Frost Gamma Investments Trust	Buy	150,000	1.70	254,400
2025-03-17	Frost Gamma Investments Trust	Buy	200,000	1.74	347,800
2025-02-28	Frost Gamma Investments Trust	Buy	67,434	1.71	115,312
2025-01-28	Frost Gamma Investments Trust	Buy	47,537	1.47	70,069
2025-01-17	Frost Gamma Investments Trust	Buy	150,000	1.47	220,500
2025-01-15	Frost Gamma Investments Trust	Buy	500,000	1.48	741,000
2024-12-11	Frost Gamma Investments Trust	Buy	500,000	1.56	781,000
2024-11-29	Frost Gamma Investments Trust	Buy	199,072	1.53	305,376
2024-11-22	Frost Gamma Investments Trust	Buy	100,000	1.59	159,000
2024-11-14	Frost Gamma Investments Trust	Buy	100,000	1.62	162,000
2024-11-08	Frost Gamma Investments Trust	Buy	280,183	1.50	421,675
2024-05-23	Frost Gamma Investments Trust	Buy	100,000	1.27	126,699
2024-05-17	Frost Gamma Investments Trust	Buy	163,997	1.29	211,228
2024-03-18	Frost Gamma Investments Trust	Buy	500,000	.87	437,000
2024-03-14	Frost Gamma Investments Trust	Buy	500,000	.89	444,500
2024-03-13	Frost Gamma Investments Trust	Buy	500,000	.93	464,000
2024-03-12	Frost Gamma Investments Trust	Buy	600,000	.93	559,200
2024-02-28	Frost Gamma Investments Trust	Buy	500,000	.99	496,000
2024-02-21	Frost Gamma Investments Trust	Buy	1,000,000	.99	992,000
2024-02-07	Frost Gamma Investments Trust	Buy	1,500,000	.97	1,462,500
2024-01-29	Krasno Richard M	Buy	30,000	.99	29,850
2024-01-19	Frost Gamma Investments Trust	Buy	500,000	.98	488,500
2024-01-18	Frost Gamma Investments Trust	Buy	400,000	.97	386,400
2024-01-17	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	150,000	.95	142,500
2024-01-16	Frost Gamma Investments Trust	Buy	1,000,000	.95	954,000
2024-01-11	Frost Gamma Investments Trust	Buy	511,531	.94	480,327
2024-01-08	Nabel Gary J. (Chief Innovation Officer)	Buy	216,184	.92	199,754
2024-01-05	Rubin Steven D (Executive VP-Administration)	Buy	10,000	.87	8,670
2024-01-05	Frost Gamma Investments Trust	Buy	1,500,000	.90	1,344,000
2024-01-05	Paganelli John A	Buy	25,000	.88	22,075
2024-01-05	Pfenniger Richard C Jr	Buy	25,000	.94	23,450
2024-01-05	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	150,010	.87	130,958
2023-11-13	Pfenniger Richard C Jr (Director)	Buy	25,000	1.30	32,500
2023-11-10	Rubin Steven D (Executive VP-Administration)	Buy	10,000	1.30	13,000
2023-08-17	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.76	175,700
2023-08-14	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	1.75	131,475
2023-08-09	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.82	181,800
2023-08-07	Frost Gamma Investments Trust (10% Owner)	Buy	650,000	1.84	1,194,050
2023-05-05	Nabel Gary J. (Chief Innovation Officer)	Buy	460,245	1.82	839,026
2023-03-22	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	1.32	264,000
2023-03-08	Frost Gamma Investments Trust (10% Owner)	Buy	1,000,000	1.20	1,197,000
2022-11-22	Frost Gamma Investments Trust (10% Owner)	Buy	300,000	1.49	447,300
2022-11-09	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	1.60	319,800
2022-10-27	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.82	181,900
2022-10-19	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.71	171,400
2022-10-14	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.73	172,500
2022-10-13	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.79	179,300
2022-10-12	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.72	172,100
2022-10-07	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	1.77	132,975
2022-09-26	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.80	89,850
2022-09-23	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.85	92,500
2022-09-22	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.90	94,750
2022-09-21	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.91	95,600
2022-09-20	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.94	96,900
2022-09-19	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.97	98,600
2022-09-15	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	2.07	413,199
2022-09-02	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	2.14	214,000
2022-08-17	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	2.54	507,599
2022-08-05	Frost Gamma Investments Trust (10% Owner)	Buy	350,000	2.28	799,050
2022-06-22	Nabel Gary J. (Chief Innovation Officer)	Buy	240,000	2.49	598,560
2022-06-21	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	2.40	479,200
2022-06-16	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	2.32	231,700
2022-06-13	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	2.36	236,400
2022-06-06	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	2.80	280,200
2022-06-01	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	2.97	148,500
2022-05-31	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	3.03	151,300
2022-05-25	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	2.98	148,950
2022-05-18	Nabel Gary J. (Chief Innovation Officer)	Buy	68,492	2.90	198,626
2022-05-18	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	2.88	144,150
2022-05-16	Frost Gamma Investments Trust (10% Owner)	Buy	150,000	2.98	446,250
2022-05-13	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	3.00	599,000
2022-05-12	Nabel Gary J. (Chief Innovation Officer)	Buy	6,979	2.65	18,494
2022-05-11	Frost Gamma Investments Trust (10% Owner)	Buy	400,000	2.83	1,132,400
2022-05-10	Zerhouni Elias A. (Vice Chairman and President)	Buy	89,600	2.79	250,432
2022-05-10	Frost Gamma Investments Trust (10% Owner)	Buy	400,000	2.78	1,113,600
2022-03-14	Frost Gamma Investments Trust (10% Owner)	Buy	35,000	3.04	106,225
2022-03-11	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	3.12	312,500
2022-02-28	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	3.10	310,400
2022-02-25	Frost Gamma Investments Trust (10% Owner)	Buy	750,000	3.09	2,315,250
2022-02-14	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	3.04	303,700
2022-02-01	Frost Gamma Investments Trust (10% Owner)	Buy	150,000	3.03	454,200
2022-01-26	Frost Gamma Investments Trust (10% Owner)	Buy	350,000	2.97	1,038,800
2021-09-14	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	3.46	346,100
2021-08-13	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	3.69	369,200
2021-08-09	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	10	3.73	37
2021-06-14	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	3.62	723,600
2021-05-25	Frost Gamma Investments Trust (10% Owner)	Buy	400,000	3.64	1,455,200
2021-05-10	Cohen Jon R (SVP OPKO; Exec Chairman BRLI)	Buy	50,000	3.81	190,500
2021-05-06	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	3.91	97,700
2021-03-05	Frost Gamma Investments Trust (10% Owner)	Buy	300,000	3.90	1,171,200
2021-02-19	Frost Gamma Investments Trust (10% Owner)	Buy	500,000	4.76	2,380,000
2021-01-25	Fishel Robert Scott (Director)	Option Ex	60,000	2.54	152,100
2020-12-28	Frost Gamma Investments Trust (10% Owner)	Buy	300,000	3.99	1,197,000
2020-11-09	Frost Gamma Investments Trust (10% Owner)	Buy	250,000	3.16	790,000
2020-10-30	Frost Gamma Investments Trust (10% Owner)	Buy	600,000	3.46	2,073,000
2020-08-26	Rubin Steven D (Executive VP-Administration)	Buy	10,000	4.00	39,960
2020-06-03	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	2.27	227,000
2020-06-02	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	2.43	243,000
2020-05-28	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	2.16	216,400
2020-05-26	Frost Gamma Investments Trust (10% Owner)	Buy	250,000	2.36	589,750
2020-05-07	Frost Gamma Investments Trust (10% Owner)	Buy	400,000	2.09	835,200
2020-04-17	Frost Gamma Investments Trust (10% Owner)	Buy	325,000	1.67	542,100
2020-04-16	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	1.63	40,700
2020-04-15	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	1.54	309,000
2020-04-07	Frost Gamma Investments Trust (10% Owner)	Buy	400,000	1.28	511,599
2020-04-03	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.16	57,750
2020-04-02	Frost Phillip Md Et Al (CEO & Chairman)	Buy	500,000	1.17	582,500
2020-04-01	Frost Gamma Investments Trust (10% Owner)	Buy	643,549	1.24	796,070
2020-03-30	Frost Gamma Investments Trust (10% Owner)	Buy	161,968	1.34	217,846
2020-03-27	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.40	139,800
2020-03-26	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	1.38	275,200
2020-03-19	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.48	148,200
2020-03-12	Japour Anthony J (Director)	Buy	500	1.51	755
2020-03-10	Frost Gamma Investments Trust (10% Owner)	Buy	300,000	1.61	482,400
2020-03-03	Japour Anthony J (Director)	Buy	500	1.47	735
2020-03-03	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.47	147,000
2020-03-02	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.49	148,800
2020-02-28	Frost Gamma Investments Trust (10% Owner)	Buy	125,000	1.45	181,625
2020-02-27	Frost Gamma Investments Trust (10% Owner)	Buy	250,000	1.48	371,000
2020-02-14	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.57	156,800
2020-02-13	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.58	158,000
2020-02-11	Frost Gamma Investments Trust (10% Owner)	Buy	14,239	1.59	22,640
2020-02-06	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.53	76,500
2020-01-31	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.44	71,750
2020-01-30	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.47	147,000
2020-01-24	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.58	79,000
2020-01-23	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.63	81,500
2020-01-17	Frost Gamma Investments Trust (10% Owner)	Buy	22,262	1.56	34,728
2020-01-13	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.44	72,000
2020-01-10	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.48	74,000
2020-01-08	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.47	73,500
2019-12-30	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.46	146,000
2019-12-27	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.52	152,500
2019-12-19	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.49	148,700
2019-12-18	Frost Gamma Investments Trust (10% Owner)	Buy	150,000	1.50	224,700
2019-12-17	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	1.53	114,975
2019-12-11	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.50	150,200
2019-12-09	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.59	79,500
2019-12-05	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.60	80,000
2019-12-03	Frost Gamma Investments Trust (10% Owner)	Buy	10,286	1.60	16,457
2019-12-02	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.56	77,800
2019-11-26	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.55	154,700
2019-11-19	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.47	146,800
2019-11-18	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	1.48	148,000
2019-11-13	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.42	71,100
2019-11-12	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	1.44	288,600
2019-11-08	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	1.48	74,150

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Insider trading activities including stock purchases, stock sales, and option exercises of OPK listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Opko Health, Inc. (symbol OPK, CIK number 944809) see the Securities and Exchange Commission (SEC) website.

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