Insider Trading activities at Opko Health, Inc. (OPK) , Part 3

Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Opko Health, Inc. (OPK) since 2006 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Opko Health, Inc.. (See page 1 of this report.) Table 2 shows the detailed insider transactions. This company's CIK number is 944809.

Total stock buying since 2006: $446,749,594.
Total stock sales since 2006: $4,562,093.
Total stock option exercises since 2006: $44,859,310.

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Table 1. Yearly summary of insider stock purchases, sales, and option exercises at *Opko Health, Inc.* (*OPK*).
	Insider Buying		Insider Sales		Option Exercises
Year	Shares	Value	Shares	Value	Shares	Value
2025	1,464,971	$2,268,356	0	$0	0	$0
2024	11,060,977	$11,232,662	0	$0	0	$0
2023	2,620,245	$4,028,551	0	$0	0	$0
2022	6,065,071	$15,298,160	0	$0	0	$0
2021	1,675,010	$6,733,537	0	$0	60,000	$152,100
2020	6,378,018	$12,211,808	0	$0	0	$0
2019	10,968,536	$20,157,698	0	$0	24,877	$16,418
2018	4,280,235	$15,828,016	0	$0	75,000	$257,250
2017	4,309,300	$29,248,220	112,975	$911,708	781,707	$2,316,267
2016	2,040,400	$18,843,589	37,500	$368,775	280,000	$313,400
2015	3,413,575	$38,939,224	41,488	$606,305	29,803,340	$26,767,986
2014	6,735,138	$56,715,211	226,030	$1,897,224	2,387,169	$5,701,640
2013	5,730,601	$42,219,434	50,000	$335,850	6,951,413	$8,990,168
2012	11,955,478	$54,117,205	0	$0	100,000	$203,700
2011	8,737,635	$32,428,441	50,000	$169,850	50,000	$28,000
2010	1,078,171	$2,505,315	0	$0	0	$0
2009	6,754,517	$6,502,506	0	$0	50,403	$43,094
2008	15,658,469	$25,674,488	100,000	$175,131	395,798	$69,287
2007	20,931,416	$51,795,693	29,500	$97,250	0	$0
2006	2,000	$1,480	0	$0	0	$0

Table 3. Detailed insider trading at *Opko Health, Inc.* (*OPK*) , Part 3
Trade Date	Insider Name	Trade Type	Shares	Price ($)	Value ($)
2018-03-07	Frost Nevada Investments Trust (10% Owner)	Buy	75,000	3.29	246,750
2018-03-07	Rubin Steven D (Executive VP-Administration)	Buy	6,000	3.25	19,500
2018-03-02	Frost Nevada Investments Trust (10% Owner)	Buy	364,800	2.94	1,073,606
2018-02-21	Frost Nevada Investments Trust (10% Owner)	Buy	172,500	3.62	625,312
2018-02-09	Frost Nevada Investments Trust (10% Owner)	Buy	185,000	3.83	708,365
2018-02-08	Frost Nevada Investments Trust (10% Owner)	Buy	20,000	4.04	80,760
2018-02-07	Frost Nevada Investments Trust (10% Owner)	Buy	78,000	4.22	329,004
2018-02-06	Frost Nevada Investments Trust (10% Owner)	Buy	60,000	4.19	251,520
2018-02-05	Frost Nevada Investments Trust (10% Owner)	Buy	50,000	4.12	206,250
2018-02-02	Frost Nevada Investments Trust (10% Owner)	Buy	55,000	4.30	236,609
2018-01-31	Frost Nevada Investments Trust (10% Owner)	Buy	65,000	4.46	289,770
2018-01-26	Frost Nevada Investments Trust (10% Owner)	Buy	55,000	4.92	270,545
2018-01-25	Frost Nevada Investments Trust (10% Owner)	Buy	75,000	4.98	373,650
2018-01-24	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	4.90	490,200
2018-01-23	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	4.76	476,100
2018-01-22	Frost Nevada Investments Trust (10% Owner)	Buy	100,000	4.38	438,100
2017-09-19	Frost Nevada Investments Trust (10% Owner)	Buy	15,000	6.00	90,045
2017-09-18	Frost Nevada Investments Trust (10% Owner)	Buy	40,000	6.00	240,080
2017-09-15	Frost Nevada Investments Trust (10% Owner)	Buy	80,000	6.00	480,400
2017-09-15	Logal Adam (Sr. Vice President, CFO)	Buy	1,500	6.03	9,045
2017-09-14	Frost Nevada Investments Trust (10% Owner)	Buy	260,000	5.98	1,555,580
2017-08-25	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	6.18	154,500
2017-08-24	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	6.23	62,340
2017-08-23	Frost Gamma Investments Trust (10% Owner)	Buy	12,000	6.12	73,452
2017-08-22	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	6.13	11,034
2017-08-21	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	6.09	152,150
2017-08-17	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	5.94	297,200
2017-08-16	Frost Gamma Investments Trust (10% Owner)	Buy	40,000	6.04	241,759
2017-08-15	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	6.09	152,200
2017-08-14	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	6.15	61,480
2017-08-11	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	6.18	61,790
2017-08-10	Frost Gamma Investments Trust (10% Owner)	Buy	39,000	6.23	243,048
2017-08-09	Frost Gamma Investments Trust (10% Owner)	Buy	18,000	6.34	114,084
2017-08-08	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	6.05	30,250
2017-08-02	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	6.14	153,625
2017-08-01	Frost Gamma Investments Trust (10% Owner)	Buy	46,600	6.25	291,389
2017-07-28	Frost Gamma Investments Trust (10% Owner)	Buy	35,100	6.29	220,849
2017-07-27	Frost Gamma Investments Trust (10% Owner)	Buy	23,600	6.34	149,718
2017-07-26	Frost Gamma Investments Trust (10% Owner)	Buy	36,200	6.38	231,064
2017-07-25	Frost Gamma Investments Trust (10% Owner)	Buy	39,800	6.42	255,396
2017-07-24	Frost Gamma Investments Trust (10% Owner)	Buy	45,000	6.42	288,945
2017-07-20	Frost Gamma Investments Trust (10% Owner)	Buy	5,400	6.46	34,873
2017-07-17	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	6.04	10,868
2017-07-14	Frost Gamma Investments Trust (10% Owner)	Buy	12,600	6.15	77,477
2017-07-12	Frost Gamma Investments Trust (10% Owner)	Buy	3,600	6.12	22,050
2017-07-10	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	6.20	309,850
2017-07-06	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	6.29	157,175
2017-07-03	Frost Gamma Investments Trust (10% Owner)	Buy	60,800	6.46	392,707
2017-06-30	Frost Gamma Investments Trust (10% Owner)	Buy	3,600	6.58	23,706
2017-06-28	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	6.87	12,366
2017-06-27	Frost Gamma Investments Trust (10% Owner)	Buy	21,800	6.77	147,673
2017-06-26	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	6.96	12,537
2017-06-22	Frost Gamma Investments Trust (10% Owner)	Buy	131,000	6.72	880,320
2017-06-15	Frost Gamma Investments Trust (10% Owner)	Buy	200,000	6.42	1,284,000
2017-06-13	Frost Gamma Investments Trust (10% Owner)	Buy	7,200	6.51	46,843
2017-06-12	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	6.37	11,457
2017-06-09	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	6.38	159,525
2017-06-07	Frost Gamma Investments Trust (10% Owner)	Buy	55,600	6.28	349,279
2017-06-06	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	6.31	189,180
2017-06-05	Frost Gamma Investments Trust (10% Owner)	Buy	55,000	6.32	347,435
2017-06-05	Lerner Richard A (Director)	Buy	10,000	6.32	63,150
2017-06-02	Pfenniger Richard C Jr (Director)	Option Ex	20,000	3.43	68,600
2017-06-01	Paganelli John A (Director)	Buy	5,000	6.17	30,840
2017-05-31	Rubin Steven D (Executive VP-Administration)	Buy	2,000	6.10	12,200
2017-05-31	Frost Gamma Investments Trust (10% Owner)	Buy	207,700	6.14	1,275,485
2017-05-30	Frost Gamma Investments Trust (10% Owner)	Buy	18,600	6.28	116,715
2017-05-26	Frost Gamma Investments Trust (10% Owner)	Buy	64,600	6.30	406,915
2017-05-25	Frost Gamma Investments Trust (10% Owner)	Buy	26,000	6.39	166,114
2017-05-24	Frost Gamma Investments Trust (10% Owner)	Buy	42,200	6.42	270,966
2017-05-22	Frost Gamma Investments Trust (10% Owner)	Buy	120,000	6.46	774,600
2017-05-19	Frost Gamma Investments Trust (10% Owner)	Buy	9,200	6.59	60,674
2017-05-18	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	6.59	131,880
2017-05-17	Frost Gamma Investments Trust (10% Owner)	Buy	70,800	6.54	462,678
2017-05-16	Frost Gamma Investments Trust (10% Owner)	Buy	27,800	6.61	183,758
2017-05-11	Rubin Steven D (Executive VP-Administration)	Buy	2,000	6.91	13,810
2017-05-11	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	20,000	6.92	138,500
2017-05-10	Frost Gamma Investments Trust (10% Owner)	Buy	1,125,000	6.96	7,830,000
2017-05-10	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	40,000	6.97	278,640
2017-05-08	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	7.22	722,000
2017-05-05	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	7.52	75,160
2017-05-04	Frost Gamma Investments Trust (10% Owner)	Buy	11,800	7.50	88,523
2017-05-03	Frost Gamma Investments Trust (10% Owner)	Buy	11,000	7.54	82,918
2017-05-02	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	7.56	113,400
2017-05-01	Frost Gamma Investments Trust (10% Owner)	Buy	4,700	7.79	36,603
2017-04-28	Frost Gamma Investments Trust (10% Owner)	Buy	9,000	7.78	70,002
2017-04-27	Frost Gamma Investments Trust (10% Owner)	Buy	22,500	7.81	175,680
2017-04-26	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	7.84	39,190
2017-04-21	Frost Gamma Investments Trust (10% Owner)	Buy	19,000	7.49	142,310
2017-04-19	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	7.48	112,230
2017-04-18	Frost Gamma Investments Trust (10% Owner)	Buy	27,800	7.27	202,050
2017-04-17	Frost Gamma Investments Trust (10% Owner)	Buy	13,600	7.48	101,687
2017-04-13	Frost Gamma Investments Trust (10% Owner)	Buy	30,800	7.57	233,032
2017-04-12	Rubin Steven D (Executive VP-Administration)	Option Ex	265,000	2.36	625,400
2017-04-11	Frost Gamma Investments Trust (10% Owner)	Buy	18,000	7.50	134,946
2017-04-10	Yu Alice Lin-tsing (Director)	Option Ex	20,000	4.72	94,400
2017-04-10	Frost Gamma Investments Trust (10% Owner)	Buy	33,000	7.62	251,361
2017-04-07	Frost Gamma Investments Trust (10% Owner)	Buy	28,000	7.58	212,240
2017-04-06	Frost Gamma Investments Trust (10% Owner)	Buy	28,600	7.58	216,902
2017-04-05	Frost Gamma Investments Trust (10% Owner)	Buy	44,500	7.71	343,050
2017-04-04	Frost Gamma Investments Trust (10% Owner)	Buy	7,400	7.68	56,832
2017-04-03	Frost Gamma Investments Trust (10% Owner)	Buy	21,600	7.84	169,408
2017-03-31	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.00	14,400
2017-03-30	Frost Gamma Investments Trust (10% Owner)	Buy	10,600	8.01	84,927
2017-03-29	Frost Gamma Investments Trust (10% Owner)	Buy	9,200	8.14	74,897
2017-03-28	Frost Gamma Investments Trust (10% Owner)	Buy	3,600	8.03	28,890
2017-03-24	Frost Gamma Investments Trust (10% Owner)	Buy	3,600	7.76	27,921
2017-03-23	Frost Gamma Investments Trust (10% Owner)	Buy	12,200	7.72	94,220
2017-03-21	Frost Gamma Investments Trust (10% Owner)	Buy	5,800	7.83	45,443
2017-03-20	Frost Gamma Investments Trust (10% Owner)	Buy	11,000	7.99	87,879
2017-03-17	Frost Gamma Investments Trust (10% Owner)	Buy	9,000	8.19	73,710
2017-03-15	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.03	14,450
2017-03-14	Logal Adam (Sr. Vice President, CFO)	Sale	112,975	8.07	911,708
2017-03-13	Logal Adam (Sr. Vice President, CFO)	Option Ex	264,207	1.46	385,742
2017-03-13	Lerner Richard A (Director)	Option Ex	20,000	2.05	41,000
2017-03-10	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	7.97	14,340
2017-03-09	Frost Gamma Investments Trust (10% Owner)	Buy	3,600	7.85	28,245
2017-03-08	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	7.92	14,256
2017-03-03	Frost Gamma Investments Trust (10% Owner)	Buy	8,600	7.43	63,880
2017-03-02	Frost Gamma Investments Trust (10% Owner)	Buy	94,800	7.53	713,749
2017-02-24	Frost Gamma Investments Trust (10% Owner)	Buy	3,600	8.46	30,463
2017-02-23	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.39	15,098
2017-02-22	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.54	15,363
2017-02-21	Frost Gamma Investments Trust (10% Owner)	Buy	3,600	8.80	31,680
2017-02-17	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.79	15,827
2017-02-16	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.65	15,570
2017-02-15	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.46	15,228
2017-02-14	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.41	15,138
2017-02-13	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.36	15,044
2017-02-10	Frost Gamma Investments Trust (10% Owner)	Buy	1,800	8.14	14,661
2017-02-09	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	8.06	80,640
2017-02-08	Rubin Steven D (Executive VP-Administration)	Buy	2,000	8.11	16,213
2017-02-08	Frost Gamma Investments Trust (10% Owner)	Buy	15,600	8.13	126,828
2017-02-07	Frost Gamma Investments Trust (10% Owner)	Buy	5,400	8.27	44,652
2017-02-06	Frost Gamma Investments Trust (10% Owner)	Buy	20,600	8.35	171,907
2017-02-02	Frost Gamma Investments Trust (10% Owner)	Buy	6,000	8.52	51,143
2017-02-01	Frost Gamma Investments Trust (10% Owner)	Buy	9,000	8.59	77,337
2017-01-31	Frost Gamma Investments Trust (10% Owner)	Buy	12,000	8.57	102,863
2017-01-30	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	8.49	84,860
2017-01-27	Frost Gamma Investments Trust (10% Owner)	Buy	12,000	8.66	103,908
2017-01-25	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	8.55	85,480
2017-01-24	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	8.45	84,500
2017-01-23	Frost Gamma Investments Trust (10% Owner)	Buy	12,000	8.48	101,736
2017-01-20	Frost Gamma Investments Trust (10% Owner)	Buy	8,600	8.73	75,043
2017-01-19	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	8.79	175,859
2017-01-19	Baron Robert A (Director)	Option Ex	60,000	3.40	204,000
2017-01-18	Frost Gamma Investments Trust (10% Owner)	Buy	10,700	8.86	94,844
2017-01-13	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	9.14	137,175
2017-01-13	Beier Thomas E (Director)	Option Ex	20,000	2.05	41,000
2017-01-04	Hsiao Jane Ph D (Vice Chairman & CTO)	Option Ex	112,500	7.61	856,125
2017-01-03	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	9.04	180,760

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Insider trading activities including stock purchases, stock sales, and option exercises of OPK listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Opko Health, Inc. (symbol OPK, CIK number 944809) see the Securities and Exchange Commission (SEC) website.

▪ Real-time Insider Trading

▪ Insider Officer Cluster Trading

▪ Top Officer Buys of the Week

▪ Top Officer Buys of the Month