Insider Trading activities at Opko Health, Inc. (OPK) , Part 10

Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Opko Health, Inc. (OPK) since 2006 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Opko Health, Inc.. (See page 1 of this report.) Table 2 shows the detailed insider transactions. This company's CIK number is 944809.

Total stock buying since 2006: $446,749,594.
Total stock sales since 2006: $4,562,093.
Total stock option exercises since 2006: $44,859,310.

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Table 1. Yearly summary of insider stock purchases, sales, and option exercises at *Opko Health, Inc.* (*OPK*).
	Insider Buying		Insider Sales		Option Exercises
Year	Shares	Value	Shares	Value	Shares	Value
2025	1,464,971	$2,268,356	0	$0	0	$0
2024	11,060,977	$11,232,662	0	$0	0	$0
2023	2,620,245	$4,028,551	0	$0	0	$0
2022	6,065,071	$15,298,160	0	$0	0	$0
2021	1,675,010	$6,733,537	0	$0	60,000	$152,100
2020	6,378,018	$12,211,808	0	$0	0	$0
2019	10,968,536	$20,157,698	0	$0	24,877	$16,418
2018	4,280,235	$15,828,016	0	$0	75,000	$257,250
2017	4,309,300	$29,248,220	112,975	$911,708	781,707	$2,316,267
2016	2,040,400	$18,843,589	37,500	$368,775	280,000	$313,400
2015	3,413,575	$38,939,224	41,488	$606,305	29,803,340	$26,767,986
2014	6,735,138	$56,715,211	226,030	$1,897,224	2,387,169	$5,701,640
2013	5,730,601	$42,219,434	50,000	$335,850	6,951,413	$8,990,168
2012	11,955,478	$54,117,205	0	$0	100,000	$203,700
2011	8,737,635	$32,428,441	50,000	$169,850	50,000	$28,000
2010	1,078,171	$2,505,315	0	$0	0	$0
2009	6,754,517	$6,502,506	0	$0	50,403	$43,094
2008	15,658,469	$25,674,488	100,000	$175,131	395,798	$69,287
2007	20,931,416	$51,795,693	29,500	$97,250	0	$0
2006	2,000	$1,480	0	$0	0	$0

Table 3. Detailed insider trading at *Opko Health, Inc.* (*OPK*) , Part 10
Trade Date	Insider Name	Trade Type	Shares	Price ($)	Value ($)
2011-03-28	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	3.75	37,550
2011-03-23	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	3.76	56,430
2011-03-22	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	3.66	91,425
2011-03-18	Frost Gamma Investments Trust (10% Owner)	Buy	25,000	3.66	91,500
2011-03-16	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	3.65	182,650
2011-03-15	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	3.70	185,100
2011-03-14	Frost Gamma Investments Trust (10% Owner)	Buy	50,000	3.73	186,400
2011-03-11	Frost Gamma Investments Trust (10% Owner)	Buy	100,000	3.71	370,500
2011-03-10	Frost Gamma Investments Trust (10% Owner)	Buy	150,000	3.52	528,450
2011-03-09	Frost Gamma Investments Trust (10% Owner)	Buy	900,000	3.62	3,256,200
2011-02-22	Frost Gamma Investments Trust (10% Owner)	Buy	30,000	4.42	132,660
2011-01-21	Frost Gamma Investments Trust (10% Owner)	Buy	1,158,000	3.52	4,078,475
2011-01-21	Hsiao Jane Ph D (Vice Chairman & CTO)	Buy	200,000	3.55	710,000
2011-01-19	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	3.67	73,340
2011-01-18	Frost Gamma Investments Trust (10% Owner)	Buy	12,500	3.90	48,687
2010-12-31	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	3.65	27,375
2010-12-23	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	3.76	56,400
2010-12-17	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	3.70	73,980
2010-12-15	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	3.71	18,550
2010-12-14	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	3.64	54,585
2010-12-03	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	3.10	30,980
2010-12-02	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	3.10	30,980
2010-12-01	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	3.10	31,000
2010-11-30	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	3.04	60,820
2010-11-29	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	3.12	15,600
2010-11-26	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	3.14	15,710
2010-11-24	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	3.06	15,285
2010-11-23	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.92	14,625
2010-11-22	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.91	14,564
2010-11-18	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.91	21,810
2010-11-17	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.84	21,300
2010-11-16	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.88	28,790
2010-11-12	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.89	28,870
2010-11-11	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.98	22,387
2010-11-09	Frost Gamma Investments Trust (10% Owner)	Buy	16,000	2.96	47,408
2010-11-05	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.99	22,402
2010-11-04	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	3.00	30,000
2010-11-03	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	2.90	43,575
2010-11-02	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.75	13,740
2010-11-01	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.71	27,080
2010-10-28	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.73	13,650
2010-10-22	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.71	13,535
2010-10-21	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.68	26,790
2010-10-19	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.61	13,050
2010-10-15	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.55	12,735
2010-10-14	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.52	12,615
2010-10-13	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.54	12,685
2010-10-12	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.42	12,075
2010-10-11	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.46	12,280
2010-10-08	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.40	23,990
2010-10-07	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.31	23,150
2010-09-22	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	2.34	35,115
2010-09-17	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.25	22,519
2010-09-15	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.19	21,900
2010-09-14	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.08	20,800
2010-09-13	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.08	15,637
2010-09-10	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.09	20,900
2010-09-07	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.10	20,950
2010-09-03	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.13	21,300
2010-09-02	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.14	10,700
2010-08-30	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.14	21,400
2010-08-27	Frost Gamma Investments Trust (10% Owner)	Buy	12,500	2.16	26,962
2010-08-26	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.17	10,825
2010-08-25	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.13	21,349
2010-08-20	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	2.21	33,150
2010-08-18	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.25	22,550
2010-08-13	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	2.19	32,775
2010-08-12	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.26	16,950
2010-08-11	Frost Gamma Investments Trust (10% Owner)	Buy	17,500	2.36	41,317
2010-08-10	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.55	25,470
2010-08-06	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.50	25,000
2010-08-05	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.62	13,100
2010-08-03	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.56	12,800
2010-07-30	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.46	12,290
2010-07-15	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.41	12,070
2010-07-07	Frost Gamma Investments Trust (10% Owner)	Buy	6,000	2.27	13,650
2010-07-06	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.24	16,800
2010-07-02	Frost Gamma Investments Trust (10% Owner)	Buy	12,500	2.19	27,412
2010-07-01	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.16	16,185
2010-06-30	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.25	16,912
2010-06-24	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.15	21,500
2010-06-23	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.07	20,660
2010-06-22	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.16	10,780
2010-06-18	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.17	10,834
2010-06-14	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.07	10,340
2010-06-11	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	1.99	9,950
2010-06-09	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	1.91	9,550
2010-06-07	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	1.93	28,890
2010-06-04	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.00	20,000
2010-05-28	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.00	9,975
2010-05-26	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	1.96	29,400
2010-05-25	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	1.99	19,900
2010-05-24	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.01	10,049
2010-05-21	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.05	15,382
2010-05-20	Frost Gamma Investments Trust (10% Owner)	Buy	12,000	2.03	24,336
2010-05-19	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.13	16,012
2010-05-14	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.10	15,734
2010-05-13	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.14	16,072
2010-05-06	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.03	20,270
2010-05-05	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.15	10,750
2010-05-04	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.20	11,000
2010-05-03	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.21	11,025
2010-04-27	Frost Gamma Investments Trust (10% Owner)	Buy	3,000	2.18	6,540
2010-04-22	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.24	11,185
2010-04-08	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.01	20,099
2010-03-24	Frost Phillip Md Et Al (CEO & Chairman)	Buy	10,000	2.02	20,170
2010-03-22	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.01	20,070
2010-03-19	Frost Gamma Investments Trust (10% Owner)	Buy	15,000	2.01	30,120
2010-03-18	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.00	19,950
2010-03-12	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.02	15,150
2010-03-11	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.02	15,112
2010-03-10	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.01	15,074
2010-03-09	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.00	15,037
2010-03-08	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.00	15,037
2010-03-04	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.02	10,100
2010-03-02	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.03	20,320
2010-03-01	Frost Gamma Investments Trust (10% Owner)	Buy	5,000	2.03	10,149
2010-02-26	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.00	19,950
2010-02-25	Frost Phillip Md Et Al (CEO & Chairman)	Buy	10,000	1.98	19,820
2010-02-24	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.00	20,000
2010-02-05	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	1.64	12,300
2010-02-04	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	1.67	16,650
2010-02-02	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	1.69	16,900
2010-02-01	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	1.71	17,120
2010-01-29	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	1.71	17,110
2010-01-21	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	1.78	17,770
2010-01-06	Frost Gamma Investments Trust (10% Owner)	Buy	113,671	1.74	198,014
2009-12-31	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	1.68	33,680
2009-12-30	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	1.60	16,050
2009-12-14	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	1.62	16,250
2009-11-18	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.05	20,500
2009-11-17	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.05	20,540
2009-11-05	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.13	21,300
2009-11-04	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	2.11	42,160
2009-11-03	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.13	21,280
2009-11-02	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	2.05	41,060
2009-10-30	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.15	21,549
2009-10-29	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	2.07	41,320
2009-10-28	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	2.05	41,000
2009-10-28	Baron Robert A (Director)	Buy	5,000	2.06	10,300
2009-10-27	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.17	21,690
2009-10-26	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	2.15	43,099
2009-10-21	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.29	22,850
2009-10-20	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.37	17,775
2009-10-19	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.38	23,800
2009-10-15	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.39	23,920
2009-10-14	Frost Gamma Investments Trust (10% Owner)	Buy	7,500	2.33	17,437
2009-10-13	Frost Gamma Investments Trust (10% Owner)	Buy	10,000	2.31	23,060
2009-10-02	Frost Gamma Investments Trust (10% Owner)	Buy	75,000	2.23	167,250
2009-08-07	Frost Gamma Investments Trust (10% Owner)	Buy	20,000	2.17	43,440

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Insider trading activities including stock purchases, stock sales, and option exercises of OPK listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Opko Health, Inc. (symbol OPK, CIK number 944809) see the Securities and Exchange Commission (SEC) website.

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