Insider Trading activities of Opko Health, Inc. insiders. , Part 8

Monthly summaries of insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Opko Health, Inc. since 2005 are illustrated in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Opko Health, Inc. since year 2005. (See page 1 of this report.) Table 2 shows the detailed insider transactions of Opko Health, Inc. since 2005. The reporting company's ticker symbol is OPK. The reporting company's CIK number is 944809.
The total value of stock buying since 2005 is $373,805,983.
The total value of stock sales since 2005 is $4,562,093.
The total value of stock option exercises since 2005 is $44,690,792.



Table 2. Detailed insider stock purchases, sales, and option exercises of Opko Health, Inc. insiders (OPK) , Part 8
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2011-11-23 Frost Gamma Investments Trust (10% Owner) Buy 15,000 4.90 73,440
2011-11-22 Frost Gamma Investments Trust (10% Owner) Buy 25,000 4.96 124,100
2011-11-21 Frost Gamma Investments Trust (10% Owner) Buy 15,000 5.01 75,150
2011-11-18 Frost Gamma Investments Trust (10% Owner) Buy 20,000 5.04 100,820
2011-11-16 Frost Gamma Investments Trust (10% Owner) Buy 30,000 5.40 162,090
2011-11-11 Frost Gamma Investments Trust (10% Owner) Buy 25,000 5.34 133,600
2011-11-10 Frost Gamma Investments Trust (10% Owner) Buy 25,000 5.13 128,350
2011-11-09 Frost Gamma Investments Trust (10% Owner) Buy 25,000 5.18 129,450
2011-11-08 Frost Gamma Investments Trust (10% Owner) Buy 25,000 5.17 129,275
2011-11-07 Frost Gamma Investments Trust (10% Owner) Buy 25,000 5.16 129,000
2011-11-04 Frost Gamma Investments Trust (10% Owner) Buy 25,000 5.13 128,150
2011-10-05 Hsiao Jane Ph D (Vice Chairman & CTO) Buy 1,200,000 3.60 4,320,000
2011-10-04 Frost Gamma Investments Trust (10% Owner) Buy 2,452,222 3.60 8,827,999
2011-09-28 Frost Gamma Investments Trust (10% Owner) Buy 15,000 4.51 67,605
2011-09-26 Frost Gamma Investments Trust (10% Owner) Buy 10,000 4.33 43,350
2011-09-23 Frost Gamma Investments Trust (10% Owner) Buy 15,000 4.36 65,415
2011-09-22 Frost Gamma Investments Trust (10% Owner) Buy 10,000 4.40 44,020
2011-09-21 Frost Gamma Investments Trust (10% Owner) Buy 20,000 4.42 88,440
2011-08-31 Paganelli John A (Director) Buy 5,000 4.14 20,690
2011-08-30 Frost Gamma Investments Trust (10% Owner) Buy 15,000 4.17 62,490
2011-08-29 Frost Gamma Investments Trust (10% Owner) Buy 20,000 4.08 81,640
2011-08-26 Frost Gamma Investments Trust (10% Owner) Buy 26,000 4.00 104,130
2011-08-26 Baron Robert A (Director) Buy 3,000 3.94 11,820
2011-08-25 Frost Gamma Investments Trust (10% Owner) Buy 25,000 3.90 97,475
2011-08-24 Frost Gamma Investments Trust (10% Owner) Buy 35,000 3.85 134,610
2011-08-23 Frost Gamma Investments Trust (10% Owner) Buy 62,500 3.77 235,312
2011-08-22 Frost Gamma Investments Trust (10% Owner) Buy 40,000 3.61 144,320
2011-08-18 Frost Gamma Investments Trust (10% Owner) Buy 25,000 3.69 92,225
2011-08-17 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.86 57,870
2011-08-16 Frost Gamma Investments Trust (10% Owner) Buy 23,000 3.90 89,815
2011-08-15 Frost Gamma Investments Trust (10% Owner) Buy 30,000 3.94 118,200
2011-08-12 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.84 192,200
2011-08-11 Frost Gamma Investments Trust (10% Owner) Buy 40,000 3.78 151,120
2011-08-10 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.69 184,350
2011-08-08 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.64 182,150
2011-08-05 Frost Gamma Investments Trust (10% Owner) Buy 125,000 3.92 489,750
2011-08-04 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.93 196,700
2011-07-27 Frost Gamma Investments Trust (10% Owner) Buy 100,000 4.12 412,500
2011-06-22 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.41 170,500
2011-06-17 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.30 164,850
2011-06-16 Uppaluri Subbarao V (Sr Vice President - CFO) Buy 1,000 3.41 3,410
2011-06-16 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.41 170,500
2011-06-15 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.42 171,000
2011-06-15 Logal Adam (Exec Dir-Fin., CAO & Treasurer) Sale 50,000 3.40 169,850
2011-06-15 Logal Adam (Exec Dir-Fin., CAO & Treasurer) Option Ex 50,000 .56 28,000
2011-06-14 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.46 172,950
2011-06-13 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.41 170,400
2011-06-13 Paganelli John A (Director) Buy 10,000 3.44 34,400
2011-06-10 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.44 68,800
2011-06-09 Frost Gamma Investments Trust (10% Owner) Buy 88,959 3.44 306,018
2011-06-08 Frost Gamma Investments Trust (10% Owner) Buy 30,000 3.53 105,900
2011-06-03 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.56 53,325
2011-06-01 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.64 181,850
2011-05-31 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.72 186,100
2011-05-27 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.76 37,600
2011-05-24 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.71 37,100
2011-05-19 Frost Gamma Investments Trust (10% Owner) Buy 35,454 3.80 134,725
2011-05-17 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.67 55,050
2011-05-16 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.67 73,400
2011-05-13 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.72 55,800
2011-05-11 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.78 56,760
2011-05-06 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.74 56,040
2011-05-05 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.72 74,420
2011-05-04 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.79 75,900
2011-05-03 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.82 76,400
2011-04-21 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.74 74,800
2011-04-18 Frost Gamma Investments Trust (10% Owner) Buy 25,000 3.78 94,500
2011-04-13 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.65 36,500
2011-04-11 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.71 55,680
2011-04-08 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.77 37,700
2011-04-06 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.78 37,800
2011-04-01 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.73 55,950
2011-03-31 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.74 56,100
2011-03-28 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.75 37,550
2011-03-23 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.76 56,430
2011-03-22 Frost Gamma Investments Trust (10% Owner) Buy 25,000 3.66 91,425
2011-03-18 Frost Gamma Investments Trust (10% Owner) Buy 25,000 3.66 91,500
2011-03-16 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.65 182,650
2011-03-15 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.70 185,100
2011-03-14 Frost Gamma Investments Trust (10% Owner) Buy 50,000 3.73 186,400
2011-03-11 Frost Gamma Investments Trust (10% Owner) Buy 100,000 3.71 370,500
2011-03-10 Frost Gamma Investments Trust (10% Owner) Buy 150,000 3.52 528,450
2011-03-09 Frost Gamma Investments Trust (10% Owner) Buy 900,000 3.62 3,256,200
2011-02-22 Frost Gamma Investments Trust (10% Owner) Buy 30,000 4.42 132,660
2011-01-21 Frost Gamma Investments Trust (10% Owner) Buy 1,158,000 3.52 4,078,475
2011-01-21 Hsiao Jane Ph D (Vice Chairman & CTO) Buy 200,000 3.55 710,000
2011-01-19 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.67 73,340
2011-01-18 Frost Gamma Investments Trust (10% Owner) Buy 12,500 3.90 48,687
2010-12-31 Frost Gamma Investments Trust (10% Owner) Buy 7,500 3.65 27,375
2010-12-23 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.76 56,400
2010-12-17 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.70 73,980
2010-12-15 Frost Gamma Investments Trust (10% Owner) Buy 5,000 3.71 18,550
2010-12-14 Frost Gamma Investments Trust (10% Owner) Buy 15,000 3.64 54,585
2010-12-03 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.10 30,980
2010-12-02 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.10 30,980
2010-12-01 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.10 31,000
2010-11-30 Frost Gamma Investments Trust (10% Owner) Buy 20,000 3.04 60,820
2010-11-29 Frost Gamma Investments Trust (10% Owner) Buy 5,000 3.12 15,600
2010-11-26 Frost Gamma Investments Trust (10% Owner) Buy 5,000 3.14 15,710
2010-11-24 Frost Gamma Investments Trust (10% Owner) Buy 5,000 3.06 15,285
2010-11-23 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.92 14,625
2010-11-22 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.91 14,564
2010-11-18 Frost Gamma Investments Trust (10% Owner) Buy 7,500 2.91 21,810
2010-11-17 Frost Gamma Investments Trust (10% Owner) Buy 7,500 2.84 21,300
2010-11-16 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.88 28,790
2010-11-12 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.89 28,870
2010-11-11 Frost Gamma Investments Trust (10% Owner) Buy 7,500 2.98 22,387
2010-11-09 Frost Gamma Investments Trust (10% Owner) Buy 16,000 2.96 47,408
2010-11-05 Frost Gamma Investments Trust (10% Owner) Buy 7,500 2.99 22,402
2010-11-04 Frost Gamma Investments Trust (10% Owner) Buy 10,000 3.00 30,000
2010-11-03 Frost Gamma Investments Trust (10% Owner) Buy 15,000 2.90 43,575
2010-11-02 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.75 13,740
2010-11-01 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.71 27,080
2010-10-28 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.73 13,650
2010-10-22 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.71 13,535
2010-10-21 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.68 26,790
2010-10-19 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.61 13,050
2010-10-15 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.55 12,735
2010-10-14 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.52 12,615
2010-10-13 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.54 12,685
2010-10-12 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.42 12,075
2010-10-11 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.46 12,280
2010-10-08 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.40 23,990
2010-10-07 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.31 23,150
2010-09-22 Frost Gamma Investments Trust (10% Owner) Buy 15,000 2.34 35,115
2010-09-17 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.25 22,519
2010-09-15 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.19 21,900
2010-09-14 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.08 20,800
2010-09-13 Frost Gamma Investments Trust (10% Owner) Buy 7,500 2.08 15,637
2010-09-10 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.09 20,900
2010-09-07 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.10 20,950
2010-09-03 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.13 21,300
2010-09-02 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.14 10,700
2010-08-30 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.14 21,400
2010-08-27 Frost Gamma Investments Trust (10% Owner) Buy 12,500 2.16 26,962
2010-08-26 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.17 10,825
2010-08-25 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.13 21,349
2010-08-20 Frost Gamma Investments Trust (10% Owner) Buy 15,000 2.21 33,150
2010-08-18 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.25 22,550
2010-08-13 Frost Gamma Investments Trust (10% Owner) Buy 15,000 2.19 32,775
2010-08-12 Frost Gamma Investments Trust (10% Owner) Buy 7,500 2.26 16,950
2010-08-11 Frost Gamma Investments Trust (10% Owner) Buy 17,500 2.36 41,317
2010-08-10 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.55 25,470
2010-08-06 Frost Gamma Investments Trust (10% Owner) Buy 10,000 2.50 25,000
2010-08-05 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.62 13,100
2010-08-03 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.56 12,800
2010-07-30 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.46 12,290
2010-07-15 Frost Gamma Investments Trust (10% Owner) Buy 5,000 2.41 12,070
2010-07-07 Frost Gamma Investments Trust (10% Owner) Buy 6,000 2.27 13,650
2010-07-06 Frost Gamma Investments Trust (10% Owner) Buy 7,500 2.24 16,800

Insider trading activities including stock purchases, stock sales, and option exercises of OPK listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Opko Health, Inc. (symbol OPK, CIK number 944809) see the Securities and Exchange Commission (SEC) website.